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 Farouc Jaffer |
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Lab Overview
Our laboratory is developing molecular imaging technology and solutions to understand cardiovascular biology in vivo. A primary focus of the laboratory is the development of MRI, optical (fluorescence), and integrated nuclear–computed tomography (SPECT/CT, PET/CT) approaches to illuminate important molecular and cellular aspects of atherosclerosis and thrombosis, including protease activity, cellular inflammation, and transglutaminase activity. The laboratory works closely with the Center for Molecular Imaging Research, a world-renowned center for small animal imaging and synthesis of novel nanomaterials. In addition to investigating in vivo biology in genetically- or pharmacologically-manipulated mouse models of cardiovascular disease, we are developing promising imaging agents for large animal translation using noninvasive MRI as well as novel catheter-based and noninvasive near infrared fluorescence (NIRF) technology in the Cardiology Laboratory of Integrative Physiology and Imaging (CLIPI) laboratory in MGH Cardiology. Successful imaging agents will be investigated in phase I/II clinical trials to evaluate their utility in diagnostic imaging and surrogate endpoints for novel pharmaceuticals.
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Figure 1.
In vivo near infrared fluorescence imaging of cysteine protease activity in atherosclerotic plaques. |
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Figure 2.
In vivo MRI and ex vivo optical imaging of cellular inflammation in apoE -/ mice using magnetofluorescent nanoparticles. |
Collaborative Relationships
Farouc Jaffer's group is part of the Vascular + Metabolic and Translational Medicine programs.
Publications
Click here to view Farouc Jaffer's publications.
For patients interested in seeing Dr. Jaffer in his clinical practice, click here to find out more or call the MGH Heart Center at 866-MGH-8910.
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