In total, the Diabetes Clinical Research Center is currently following more 1000 research participants in our studies conducted at Mass General. Click on the page links for more information about these studies.
Current Research Clinical Trials
Notable Past Research Clinical Trials
- A1c-Derived Average Glucose Study: International study to determine whether A1c values can be translated into estimated average glucose values to aid management;
- Closed loop pump therapy of type 1 diabetes: Development of an artificial pancreas for the treatment of type 1 diabetes;
- Comparative study of insulin therapy of type 2 diabetes;
- Continuous glucose monitoring (CGM) in the Intensive Care Unit: Examination of different CGM devices to determine whether they can be used to guide therapy in the intensive care unit setting;
- Diabetes Prevention Program Outcome Study: Follow-up of the Diabetes Prevention Program cohort to determine the long-term effects of diabetes prevention;
- Epidemiology of Diabetes Interventions and Complications Study: Follow-up of DCCT cohort to examine the long-term effects of intensive therapy;
- Inpatient management of diabetes study: Development of new methods of inpatient treatment and education;
- LookAHEAD Study: Examines the means of preventing heart disease in Type 2 diabetes;
- Management of type 2 diabetes guided by genetic testing: Determination of the effect of genetics on responsiveness to different treatments of type 2 diabetes
- Reversal of type 1 diabetes with BCG treatment: Pilot study based on previous mouse studies to reverse the autoimmunity of type 1 diabetes;
- TODAY: Study of the best means to treat type 2 diabetes in children and adolescents.
Other Clinical Research
- Diabetes Control and Complications Trial (DCCT): Hailed as the most important studies in diabetes since the discovery of insulin, the DCCT demonstrated the primacy of intensive metabolic control in preventing the development of complications in Type 1 diabetes and established Mass General as one of the premier centers for the study of type 1 diabetes and its complications
- Implantable Pump Project: an international study lead by MGH investigators that established the utility of an implantable pump (first developed by MGH investigators, in the treatment of type 1 diabetes.
- Whole organ transplantation: the first progrsm in New England to estasblish a high rate of success and safety of simultaneous kidney/pancreas transplantation.
- Islet transplantation: the first successful isolation and purification of human islets in New England with subsequent transplantation
- Diabetes Prevention Program (DPP) : A multicenter, NIH-sponsored study, lead by MGH investigators, that established the means of preventing Type 2 diabetes.
- Immune Tolerance Network Study: an international study investigating islet transplantation as a treatment of Type 1 diabetes.
- Established a 75% success rate in normalizing blood sugar control in type 1 diabetes.
In addition to the clinical trial studies highlighted above, the MGH Diabetes Unit performs studies of human physiology and numerous epidemiologic studies in collaboration with the Framingham Heart Study, Baltimore Longitudinal Study of Aging, and Nurses and Physicians Health Studies that have explored the risk factors of diabetes and its complications and in particular the relationship between glycemia and heart disease. Other areas of active research includes quality improvement and health care policy research.