Diabetes Clinical Research Center

Overview

The Diabetes Unit at Mass General is recognized for its longstanding excellence in diabetes research and its significant contributions to the advancement of effective treatments. Noteworthy developments include the creation of the Bionic Pancreas (in partnership with Boston University), implantable insulin pumps, and innovative techniques for assessing long-term glucose control. Additionally, the GLP-1 was first tested in human subjects at the MGH Diabetes Research Center.

Researchers at Massachusetts General Hospital have led pivotal studies in disease and complication prevention, including the highly cited Diabetes Control and Complications Trial (DCCT) and the Diabetes Prevention Program. Ongoing research continues to build upon foundational work in the Diabetes Research Center, focusing on evidence generation across all types of diabetes, atypical presentations, diverse populations, epidemiology, genetics, precision medicine, individuals who are pregnant or lactating, and complication prevention. The availability of dedicated research examination rooms and laboratory facilities enables efficient processing and shipment of biological samples, thereby expediting study workflows and results.

Our Team

Our interdisciplinary team comprises physicians, bench scientists, epidemiologists, statisticians, dietitians, nurses, clinical research coordinators, research technicians, students, and research fellows. This collective expertise supports our mission to advance the diagnosis, prevention, and treatment of all forms of diabetes and their associated complications.

Collaborations

We maintain collaborative partnerships with academic and industry researchers worldwide. Current collaborations include the Mass General Brigham Center for Genomic Medicine, the Broad Institute, and the Boston Area Diabetes Endocrinology Research Centers (BADERC). For inquiries regarding future collaborations, please contact us.

Group Members

Our researchers include epidemiologists, physicians, bench scientists, dietitians and nurses.

Clinical Investigators

• Tara Bresnahan, MBA, RN, CRN-BC
• Sara Cromer, MD
• Linda M. Delahanty, MS, RDN
• Jose C. Florez, MD, PhD
• Mary Larkin, MS, RN, CDE
• Aaron Leong, MD
• Josephine Li, MD
• David M. Nathan, MD
• Camille E. Powe, MD
• Melissa Putman, MD
• Jackie Seiglie, MD
• Deborah J. Wexler, MD

Clinical Research Dietitians

• Denise Arthurs, MS, RD, LDN
• Sarah Keller, RD
• Jeanna McCarthy, MS, RD
• Linda M.Delahanty, MS, RDN

Publications

View recent publications from the Diabetes Clinical and Translational Research Center. Some full-text articles may require a subscription.

Research Projects

The Diabetes Research Center is actively conducting clinical trials in areas such as cystic fibrosis-related diabetes, gestational diabetes, tumor-associated hyperinsulinism (tHI), rare and atypical diabetes, type 1 and type 2 diabetes, and lifestyle interventions targeting disease prevention.

For details on ongoing trials, visit rally.massgeneralbrigham.org and for a summary of our trials, see below.

For information about the MGH Diabetes Center Repository, visit here.

Diabetes Research Center Current and Past Trials

Selected current, recent, and past trials are listed below.