Photo of Paul Alfred Boepple, MD

Paul Alfred Boepple, MD

617-726-2909

Accepting New Patients

Overview

Departments

Pediatrics

Centers & Specialties

MassGeneral Hospital for Children

Clinical Interests
  • Adrenal disorders
  • Pituitary disease
  • Diabetes management
  • Adolescent menstrual disorders
  • Growth disorders
  • Diabetes mellitus type 1
  • Diabetes mellitus type 2
  • Disorders of puberty
  • Obesity medicine
  • Pediatric endocrinology
Medical Education
  • MD, University of Vermont College of Medicine
  • Residency, Duke University Medical Center
  • Fellowship, Massachusetts General Hospital
Board Certifications
  • Pediatrics
  • Pediatric Endocrinology
Locations
  • Boston: Massachusetts General Hospital
  • Danvers: The Mass General/North Shore Center for Outpatient Care
  • Forestdale: Rehabilitation Hospital of the Cape and Islands
Insurances Accepted
  • Aetna Health Inc.
  • Beech Street
  • Blue Cross Blue Shield - Blue Care 65
  • Blue Cross Blue Shield - Indemnity
  • Blue Cross Blue Shield - Managed Care
  • Blue Cross Blue Shield - Partners Plus
  • Cigna (PAL #'s)
  • Fallon Community HealthCare
  • Great-West Healthcare (formally One Health Plan)
  • Harvard Pilgrim Health Plan - ACD
  • Harvard Pilgrim Health Plan - PBO
  • Health Care Value Management (HCVM)
  • Humana/Choice Care PPO
  • MassHealth
  • Medicare
  • Medicare - ACD
  • Neighborhood Health Plan - ACD
  • Neighborhood Health Plan - PBO
  • OSW - Maine
  • OSW - New Hampshire
  • OSW - Rhode Island
  • Private Health Care Systems (PHCS)
  • Railroad Medicare
  • Senior Whole Health
  • TriCare
  • Tufts Health Plan
  • Unicare
  • United Healthcare (non-HMO) - ACD
  • United Healthcare (non-HMO) - PBO

Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.

Patient Age Group
Pediatric
Gender
Male

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Biography

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Research & Publications

Research Summary

My research contributions have focused on the neuroendocrine maturation of human puberty and the modulation of childhood and adolescent growth through the interactions between the reproductive and growth hormone axes. Investigations have predominantly employed clinical models of human puberty, including children with sexual precocity, adolescents with delayed puberty, and adults with deficiencies of gonadotropin-releasing hormone. In addition to providing physiological insights, the data we compiled in our studies of children with precocious puberty (CPP) were the basis for the first FDA approval of the use of GnRH agonists for this indication. Since that approval in 1991, GnRH agonist therapy of children with CPP has become the standard of care around the world. Subsequently, investigations undertaken with colleagues in the MGH Reproductive Endocrine Unit helped elucidate the complex interaction of GnRH, sex steroids, and inhibin in the differential regulation of LH and FSH in the human male through the study of a variety of clinical research models (children with CPP before, during, after treatment with GnRH agonists; men with GnRH deficiency before and after restoration of a normal, adult testosterone levels by administration of pulsatile GnRH; adult male volunteers before and after short-term, reversible “biochemical castration” achieved by high-dose ketoconazole). I continue to contribute to clinical research studies in the MGH Reproductive Endocrine Unit that characterize the phenotype/genotype correlations in adult subjects with hypogonadotropic hypogonadism and then seek insights into the genetic basis for variations in pubertal timing and reproductive disorders. Most recently, sequencing of a set of genes known to underlie GnRH deficiency was undertaken in patients with delayed puberty and hypothalamic amenorrhea. Learn more about pediatric endocrine research.

Publications

View my most recent publications at PubMed

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Contact

Pediatric Endocrine Associates
55 Fruit Street
Boston MA, 02114-2696
Phone: 617-726-2909
Fax: 617-724-0581
Mass General/North Shore Center for Outpatient Care
104 Endicott Street
Danvers MA, 01923-3623
Phone: 888-644-3248
Fax: 978-882-6989

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