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Sriram Machineni, MBBS

  • Phone: 617-726-4400
Department of Medicine


  • Digestive Healthcare Center
  • Weight Center
Clinical Interests
Multi-disciplinary management of obesity
Weight loss medication use for treatment of obesity
Nutritional deficiencies after bariatric surgery
Inadequate weight loss after bariatric surgery
Weight regain after bariatric surgery
Boston: Massachusetts General Hospital
Medical Education
MBBS, All India Institute of Medical Sciences
Residency, All India Institute of Medical Sciences
Residency, Apollo Hospital
Residency, Buffalo General Hospital/Kaleida
Residency, Erie County Medical Center
Fellowship, Massachusetts General Hospital
Board Certifications
Internal Medicine, American Board of Internal Medicine
Patient Gateway
Yes, learn more
Foreign Languages
Patient Age Group
Accepting New Patients
Accepting New Patients

BiographyDr. Machineni attended medical school at the All India Institute of Medical Sciences and completed his residency in Internal Medicine from the State University of New York at Buffalo. He was recruited as staff physician at the Buffalo General Hospital, after serving as the chief medical resident. At the Buffalo General hospital, he served in the roles of Director of the Primary Medicine and the Weight Management clinics. Dr. Machineni moved to New York City to conduct clinic research in diabetes and weight loss surgery and worked with Dr. Blandine Laferrere at the New York Nutrition and Obesity Research Center. He then moved to Boston to pursue a clinical and research fellowship in Obesity Medicine and Nutrition at the Massachusetts General Hospital (MGH). He presently serves in the role of Assistant in Medicine at MGH and holds the appointment of Instructor in Medicine at Harvard Medical School.

ResearchDr. Machineni's research focus is the exploration of mechanisms of action of bariatric surgery and energy balance regulation. His work is aimed towards helping design novel, effective and safe therapies for obesity. He is presently involved in clinical research as well as animal model research projects studying the the determinants of the weight outcomes after gastric bypass and the influence that nutrition has on energy balance regulation. He is a part of ongoing clinical research studies and medication trials at the MGH weight center.


  1. Liou AP, Paziuk M, Luevano JM Jr, Machineni S, Turnbaugh PJ, Kaplan LM. Conserved shifts in thegut microbiota due to gastric bypass reduce host weight and adiposity. Sci Transl Med., 2013.5(178):178ra41.
  2. Bose M, Machineni S, Oliv?n B, Teixeira J, McGinty JJ, Bawa B, Koshy N, Laferr?re B. Superior appetite hormone profile after equivalent weight loss by gastric bypass compared to gastric banding.Obesity, 2010. 18(6):1085-91. PMCID: 2877144.
  3. Bose M, Teixeira J, Oliv?n B, Bawa B, Arias S, Machineni S, Pi-Sunyer FX, Scherer PE, Laferr?re B. Weight loss and incretin responsiveness improve glucose control independently after gastric bypass surgery. J Diabetes, 2010. 2(1):47-55. PMCID: 2910618.
  4. Kumar, R., A.K. Padhy, S. Machineni, A.K. Pandey, and A. Malhotra. Individual kidney glomerular filtration rate in the interpretation of non-diagnostic curves on captopril renography. Nucl Med Commun, 2000. 21(7): p. 637-43.
  5. Kumar, R., S. Dilip, A.K. Padhy, R. Malhotra, A. Malhotra, S. Machineni, and R. Sharma.Three-phase bone imaging in the early diagnosis of osteochondritis dissecans of the patella.Clin Nucl Med, 1998. 23(8): p. 540-1.

Weight Center, MGH
50 Staniford Street
4th Floor
Boston, MA 02114-2517

Phone: 617-726-4400
Fax: 617-724-1515

Weight Center, MGH
50 Staniford Street
4th Floor
Boston, MA 02114-2517

Phone: 617-726-4400
Fax: 617-724-1515


#3 in the nation for digestive care

U.S. News & World Report ranks Mass General gastroenterology third among U.S. hospitals.