Lewis Ball Holmes, MD
Emeritus Unit Chief, Medical Genetics, Pediatric Service
Emeritus Director, Genetic Counseling & Screening Services,
Perinatal Diagnostic Unit, Obstetrics Program
- Department of Pediatrics
- MassGeneral Hospital for Children
- Clinical Interests
- Epidemiology of malformations
- Hereditary malformations
- Human teratogens
- Causes of malformations
- Prenatal Testing and Diagnosis
- Boston: Massachusetts General Hospital
- Medical Education
- MD, Duke University School of Medicine
- Residency, Massachusetts General Hospital
- Fellowship, Massachusetts General Hospital
- Board Certifications
- Pediatrics, American Board of Pediatrics
- Clinical Genetics (M.D.), American Board of Medical Genetics
- Patient Age Group
- Adult and pediatric
- Accepting New Patients
- Insurances Accepted
- Aetna Health Inc.
Blue Cross Blue Shield - Blue Care 65
Blue Cross Blue Shield - Indemnity
Blue Cross Blue Shield - Managed Care
Blue Cross Blue Shield - Partners Plus
Cigna (PAL #'s)
Fallon Community HealthCare
Great-West Healthcare (formally One Health Plan)
Harvard Pilgrim Health Plan - ACD
Harvard Pilgrim Health Plan - PBO
Health Care Value Management (HCVM)
Humana/Choice Care PPO
Neighborhood Health Plan - ACD
Neighborhood Health Plan - PBO
OSW - Maine
OSW - New Hampshire
OSW - Rhode Island
Private Health Care Systems (PHCS)
Tufts Health Plan
United Healthcare (non-HMO) - ACD
United Healthcare (non-HMO) - PBO
ResearchFor the past 40 plus years, I have worked on two major research projects: 1) searching for the causes of congenital malformations in infants; 2) determining the fetal effects from exposures during pregnancy. The first project was explored for 40 years (1972-2012) in the evaluation of all malformed liveborn and stillborn infants born at the Brigham and Women's Hospital in Boston. The focus of the second project has been on the effects of anticonvulsant drugs taken by pregnant women, as well as several other exposures.
- Gold NB, Westgate MN, Holmes LB. Anatomic and etiological classification of congenital limb deficiencies. Am J Med Genet (Part A) 155:1225-1235, 2011.
- Holmes LB, Westgate MN. Inclusion and exclusion criteria for malformations in newborn infants exposed to potential teratogens. Birth Def Res (Part A): Clin Mol Teratol 91:807-812, 2011.
- Gardiner DM, Holmes LB. Hypothesis: terminal transverse limb defects with "nubbins" represent a regenerative process during limb development in human fetuses. Birth Def Res (Part A): Clin Mol Teratol 94:129-133, 2012.
- Hernandez-Diaz S, Smith CR, Shen A, Mittendorf R, Hauser WA, Yerby M, Holmes LB. Comparative safety of antiepileptic drugs during pregnancy. Neurology 78:1692-1699, 2012.
- Mehta U, Clerk C, Allen E, Yore M, Sevene E, Singlovic J, Petzold M, Mangiaterra V, Elefant E, Sullivan FM, Holmes LB, Gomes M. Protocol for a drug exposure pregnancy registry for implementation in resource-limited settings. BMC Pregnant Childbirth 12:89, 2012.
- Maheshware A, Athale S, Lekhra OP, Tela K, Hernandez-Diaz S, Holmes LB. Comparative safety of antiepileptic drugs during pregnancy. 80:689-690, 2013.
- Holmes LB. Common Malformations, Oxford University Press, NY, 2012.
This course is designed for obstetricians, geneticists, genetic counselors, nurse midwives, nurse in obstetrics, nurse practitioners, pediatricians, family practitioners, and internists.
At the end of this course, participants will be able to:
• Analyze the scientific data available to determine whether an exposure in utero poses a potential risk for damage to the fetus.
• Use online databases and published articles as a resource to gain information on the effect of various teratogens on the unborn fetus and use these sources in practice.
• Counsel your patients who have experienced an environmental exposure so they understand the possible risks to the fetus in utero.
Medical Genetics Unit/MGHfC
175 Cambridge Street
Boston, MA 02114
Phone 2: 617-726-1745
Call the Massachusetts General Hospital physician referral service at 800-711-4644.
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