Clinical Interests
  • Epidemiology of malformations
  • Hereditary malformations
  • Teratogens
  • Causes of malformations
  • Prenatal Testing and Diagnosis
  • Birth defects
Medical Education
  • MD, Duke University School of Medicine
  • Residency, Massachusetts General Hospital
  • Fellowship, Massachusetts General Hospital
Board Certifications
  • Pediatrics
  • Clinical Genetics (M.D.)
  • Boston: Massachusetts General Hospital
Insurances Accepted
  • Aetna Health Inc.
  • Beech Street
  • Blue Cross Blue Shield - Blue Care 65
  • Blue Cross Blue Shield - Indemnity
  • Blue Cross Blue Shield - Managed Care
  • Blue Cross Blue Shield - Partners Plus
  • Centene/Celticare
  • Cigna (PAL #'s)
  • Fallon Community HealthCare
  • Great-West Healthcare (formally One Health Plan)
  • Harvard Pilgrim Health Plan - ACD
  • Harvard Pilgrim Health Plan - PBO
  • Health Care Value Management (HCVM)
  • Humana/Choice Care PPO
  • Medicaid
  • Medicare
  • Medicare - ACD
  • Neighborhood Health Plan - ACD
  • Neighborhood Health Plan - PBO
  • OSW - Maine
  • OSW - New Hampshire
  • OSW - Rhode Island
  • Private Health Care Systems (PHCS)
  • TriCare
  • Tufts Health Plan
  • Unicare
  • United Healthcare (non-HMO) - ACD
  • United Healthcare (non-HMO) - PBO
Patient Age Group
Adult and Pediatric

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Research & Publications

Research Summary
For the past 40 plus years, I have worked on two major research projects: 1) searching for the causes of congenital malformations in infants; 2) determining the fetal effects from exposures during pregnancy.  The first project was explored for 40 years (1972-2012) in the evaluation of all malformed liveborn and stillborn infants born at the Brigham and Women's Hospital in Boston.  The focus of the second project has been on the effects of anticonvulsant drugs taken by pregnant women, as well as several other exposures.
  1. Gold NB, Westgate MN, Holmes LB. Anatomic and etiological classification of congenital limb deficiencies. Am J Med Genet (Part A) 155:1225-1235, 2011.
  2. Holmes LB, Westgate MN. Inclusion and exclusion criteria for malformations in newborn infants exposed to potential teratogens. Birth Def Res (Part A): Clin Mol Teratol 91:807-812, 2011.
  3. Gardiner DM, Holmes LB. Hypothesis: terminal transverse limb defects with "nubbins" represent a regenerative process during limb development in human fetuses.  Birth Def Res (Part A): Clin Mol Teratol 94:129-133, 2012.
  4. Hernandez-Diaz S, Smith CR, Shen A, Mittendorf R, Hauser WA, Yerby M, Holmes LB.  Comparative safety of antiepileptic drugs during pregnancy.  Neurology 78:1692-1699, 2012.
  5. Mehta U, Clerk C, Allen E, Yore M, Sevene E, Singlovic J, Petzold M, Mangiaterra V, Elefant E, Sullivan FM, Holmes LB, Gomes M.  Protocol for a drug exposure pregnancy registry for implementation in resource-limited settings.  BMC Pregnant Childbirth 12:89, 2012.
  6. Maheshware A, Athale S, Lekhra OP, Tela K, Hernandez-Diaz S, Holmes LB.  Comparative safety of antiepileptic drugs during pregnancy.  80:689-690, 2013.
  7. Holmes LB.  Common Malformations, Oxford University Press, NY, 2012.

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Medical Genetics Unit/MGHfC
175 Cambridge Street
Fifth floor
Boston MA, 02114
Phone: 617-726-1742617-726-1745
Fax: 617-724-1911

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