Dr. Colvin is subspecialty head of Renal Pathology, and works closely with the diagnostic Immunopathology Unit in Pathology. He is also affiliated with the Kidney/Pancreas/Islet Transplant Programs at the Transplant Center at Mass General Hospital.



Centers & Specialties

Transplant Center

Clinical Interests
  • Renal Pathology
Medical Education
  • MD, Harvard Medical School
  • Residency, Massachusetts General Hospital
Board Certifications
  • Immunopathology
  • Anatomic Pathology
  • Boston: Massachusetts General Hospital
Insurances Accepted
  • Aetna Health Inc.
  • Beech Street
  • Blue Cross Blue Shield - Blue Care 65
  • Blue Cross Blue Shield - Indemnity
  • Blue Cross Blue Shield - Managed Care
  • Blue Cross Blue Shield - Partners Plus
  • Centene/Celticare
  • Cigna (PAL #'s)
  • Fallon Community HealthCare
  • Great-West Healthcare (formally One Health Plan)
  • Harvard Pilgrim Health Plan - ACD
  • Harvard Pilgrim Health Plan - PBO
  • Health Care Value Management (HCVM)
  • Humana/Choice Care PPO
  • Medicaid
  • Medicare
  • Medicare - ACD
  • Neighborhood Health Plan - ACD
  • Neighborhood Health Plan - PBO
  • OSW - Maine
  • OSW - New Hampshire
  • OSW - Rhode Island
  • Private Health Care Systems (PHCS)
  • Railroad Medicare
  • Railroad Medicare - ACD
  • Senior Whole Health
  • TriCare
  • Tufts Health Plan
  • Unicare
  • United Healthcare (non-HMO) - ACD
  • United Healthcare (non-HMO) - PBO
Patient Age Group

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Dr. Colvin's principal clinical interest is renal pathology, particularly the immunological aspects of renal disease and transplantation. He is the subspecialty head of the Renal Pathology Diagnostic Service, works closely with the Immunopathology Unit , and is affiliated with the Kidney/Pancreas/Islet Transplant Programs at the Massachusetts General Hospital Transplant Center. He has contributed seminal work in the field of antibody mediated rejection, and approaches to tolerance induction. He is a senior investigator in the Immunopathology Research Laboratory and the Colvin Laboratory, and has been continuously funded by the NIH since 1976. He teaches at Harvard Medical School, has trained over 45 fellows, and lectures widely.  

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Research & Publications

Research Summary

Dr. Colvin contributed seminal work in the field of antibody mediated rejection and approaches to tolerance induction. The C4d assay that is now used in transplant centers worldwide in the diagnosis of antibody-mediated rejection of allografts. He is a principal investigator and head of the Immunopathology Research Laboratory, for translational research in immunology and transplantation, and has been continuously funded by the National Institutes of Health (NIH) since 1976. The Colvin Laboratory focuses on the mechanisms of allograft rejection and acceptance in animal and human studies, as revealed by pathologic, immunopathologic and molecular techniques. Dr. Colvin is affiliated with the Center for Transplantation Sciences  (CTS).  His other research interests include acute and chronic antibody-mediated rejection, and mechanisms of graft acceptance. For a list of co-authors, related research concepts, and more visit Dr. Colvin's profile page at Harvard Clinical and Translational Science Center. For more about the history of Dr. Colvin's research and clinical contributions, see the history of pathology services at Massachusetts General Hospital, Chapter 25.


View my most recent publications at PubMed


  1. Long-Term Lung Transplantation in Nonhuman Primates. Aoyama A, Tonsho M, Ng CY, Lee S, Millington T, Nadazdin O, Wain JC, Cosimi AB, Sachs DH, Smith RN, Colvin RB, Kawai T, Madsen JC, Benichou G, Allan JS. Am J Transplant. 2015 Mar 13. doi: 10.1111/ajt.13130. [Epub ahead of print]>
  2. Immunomodulatory Strategies Directed Toward Tolerance of Vascularized Composite Allografts. Madariaga ML, Shanmugarajah K, Michel SG, Villani V, La Muraglia GM 2nd, Torabi R, Leonard DA, Randolph Mas MA, Colvin RB, Yamada K, Madsen JC, Cetrulo CL Jr, Sachs DH. Transplantation. 2015 Mar 9. [Epub ahead of print]
  3. Recipient-Matching of Passenger Leukocytes Prolongs Survival of Donor Lung Allografts in Miniature Swine. Madariaga ML, Michel SG, La Muraglia GM 2nd, Sihag S, Leonard DA, Farkash EA, Colvin RB, Cetrulo CL Jr, Huang CA, Sachs DH, Madsen JC, Allan JS. Transplantation. 2015 Mar 9. [Epub ahead of print]

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Pathology Associates
55 Fruit Street
Boston MA, 02114-2696
Phone: 617-724-3631
Fax: 617-724-5833

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