Massachusetts General Hospital

Research

General Theme : Coronary Artery Disease And Treatment: Thrombolysis was introduced at MGH with Dr.Gold and Dr.Leinbach in 80's. Now I am interested in preventing atherosclerosis and peripheral artery disease inclusding coronary artery disease. Both  treatment and diagnostic Imaging are my interests.

Hyperlipidemia : As a part of above interest, I have been conducting Cholesterol transfer protein Inhibitor research in human as a Principle investigator at MGH.

Cardiac Imaging ( Nuclareat cardiology and molecular Imaging) : Using my traning in research and clinical expertiese, new imaging agents have been investigated and currently a new PET imaging agent  for myocardial perfusion and stress testing has been investigated as a part of multicenter trial.  In addition, other metabolic imaging agents have been investigated: Free Fatty acid and myocardial imgaging. Norepinephrine transperter imaging in heart failure patient.  

PET and CT : Molecular dynamics of Myocardium or vasculature  are key to understanding aging process as well as pathological process of cardiovascular illness. These imaging tedhnology would provide a new insight and combined knowledge of anatomical and the state of molecular Cell Biology. Currently multiple studies have been planned.

Publications

Original Articles

23.  Yasuda T, Palacios IF, Dec GW, Fallon JT, Gold HK, Leinbach RC, Strauss HW, Khaw BA, Haber:  Indium-111 monoclonal antimyosin antibody imaging in the diagnosis of acute myocarditis.  Circulation 1987; 76:306-311.

50.  Yasuda T, Gold HK, Leinbach RC, Saito T, Guerrero JL, Jang IK, Holt R, Fallon JT, Collen D.  Lysis of rt-PA resistant platelet-rich coronary arterial thrombus with combined bolus injection of recombinant tissue-type plasminogen activator (rt-PA) and anti-platelet GPIIIa antibody.  J Am Coll Cardiol 1990; 16:1728-35.

76. Akutsu, Y, Gregory, S, Kardan A, Zervos GD, Thomas GS, Gewirtz H,  Yasuda T. Delayed heart rate recovery after adenosine stress testing with supplemental arm exercise predicts mortality.  J Nuc Cardiol 2009; 16: 54-62.

AWARE trial takes aim at chronic chest pain

Physicians at the Massachusetts General Hospital Heart Center are investigating a new tool that could ease chronic chest pain in women.