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E Tessa Hedley-Whyte, MD, MBBS

Pathologist, Massachusetts General Hospital

Professor of Pathology, Harvard Medical School

Dr. Hedley-Whyte provides services to Mass General, and consulting services for patients, physicians and pathologists in the United States and abroad. She further specializes in neurodegenerative diseases in collaboration with the MADRC.

Department of Pathology


  • Cancer Center
  • Neuro-Oncology (Brain)
Clinical Interests
Autopsy Pathology
Frozen Section Pathology
Boston: Massachusetts General Hospital
Medical Education
MBBS, Kings College @ University of Durham
MD, Newcastle University
Residency, Children's Hospital Boston
Fellowship, Children's Cancer Research Foundation
Board Certifications
Anatomic Pathology, American Board of Pathology
Neuropathology, American Board of Pathology
Patient Age Group
Accepting New Patients
Accepting New Patients


Dr. E. Tessa Hedley-Whyte is Professor of Pathology specializing in neuropathology and a Principal Investigator in the Massachusetts Alzheimer's Disease Research Center. She is the author of over 150 research papers with topics ranging from pediatric neuropathology, particularly pituitary tumors, to Alzheimer?s disease. She is deeply involved at Harvard Medical School in medical education, assisting in the admission and evaluation of students, and shaping the medical curriculum.

To learn more about her contributions to the field of Pathology and to the Pathology Service at Massachusetts General Hospital, refer to Chapter 17, Neuropathology, from Keen Minds to Explore the Dark Continents of Disease, a book on the Department?s history.


Dr. Hedley-Whyte is co-investigator of the Neuropathology Core of the Massachusetts Alzheimer's Disease Research Center (ADRC). The Core's mission is to conduct neuropathological examinations on brains submitted to the Harvard Brain Tissue Resource Center and distribute tissue to ADRC investigators. The ADRC includes investigators with expertise in neuropathology, morphometry, immunocytochemistry, microarray technology, gene chip applications, laser capture techniques and in situ hybridization, and brain banking procedures. With Dr. Matthew Frosch, we use procedures to enhance the value of the brain tissues to investigators whose specific research projects depend upon receiving carefully prepared and diagnosed tissue. Standardized protocols for tissue acquisition, and dissection procedures ensure complete and reproducible examinations across all cases. The Tissue Resource Center maintains a rich collection of paraffin blocks with frozen, and formalin-fixed tissue. Frozen tissue is available as small blocks, and thin whole coronal brain slices, in which all anatomical structures are clearly visible. Separate databases within the Harvard Brain Tissue Resource Center contain information on tissue availability, location, and investigator allocation.

Dr. Hedley-Whyte's other research interests include predictive histological markers of pituitary tumor behavior.


View my most recent publications at PubMed

  1. Pathologic and clinical features of pituitary adenomas showing TSH immunoreactivity. Tritos NA, Eppakayala S, Swearingen B, Hedley-Whyte ET, Miller KK, Nachtigall LB, Grinspoon SK, Biller BM, Klibanski A. Pituitary. 2013 Sep; 16(3):287-93.
  2. Ataxia, dementia, and hypogonadotropism caused by disordered ubiquitination.Margolin DH, Kousi M, Chan YM, Lim ET, Schmahmann JD, Hadjivassiliou M, Hall JE, Adam I, Dwyer A, Plummer L, Aldrin SV, O'Rourke J, Kirby A, Lage K, Milunsky A, Milunsky JM, Chan J, Hedley-Whyte ET, Daly MJ, Katsanis N, Seminara SB. N Engl J Med. 2013 May 23; 368(21):1992-2003
  3. Bifocal intracranial tumors of nongerminomatous germ cell etiology: diagnostic and therapeutic implications. Aizer AA, Sethi RV, Hedley-Whyte ET, Ebb D, Tarbell NJ, Yock TI, Macdonald SM. Neuro Oncol. 2013 Jul; 15(7):955-60.

Massachusetts General Hospital
55 Fruit Street
Boston, MA 02114-2696

Phone: 617-726-5154
Phone 2: 617-724-1465
Fax: 617-724-1813

Massachusetts General Hospital
55 Fruit Street
Boston, MA 02114-2696

Phone: 617-726-5154
Phone 2: 617-724-1465
Fax: 617-724-1813

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