Massachusetts General Hospital

Biography

Pathologist
Massachusetts General Hospital

Professor of Pathology
Harvard Medical School

Email: ehedleywhyte@partners.org

Affiliations
MGH Center for Aging and Neurodegeneration

Research

Dr. Hedley-Whyte is the co-investigator of the Neuropathology Core of the Massachusetts Alzheimer Disease Research Center (ADRC), established more than 25 years ago as an integral part of the ADRC at MGH. The mission of this Core is to conduct neuropathological examinations on the brains submitted to the Tissue Resource Center and to distribute tissue to ADRC investigators. With Dr. Frosch, we use procedures to enhance the value of these brain tissues to individual investigators whose specific research projects depend upon receiving carefully prepared and diagnosed tissue.

This Neuropathology Core includes investigators with expertise in neuropathology, morphometry, immunocytochemistry, microarray technology, gene chip applications, laser capture techniques and in situ hybridization, as well as expertise in brain banking procedures. We use standardized protocols for tissue acquisition and dissection procedures that ensure complete and reproducible examinations across all cases received. The Tissue Resource Center maintains a rich collection of paraffin blocks and frozen as well as formalin-fixed tissue. The frozen tissue is available both as small blocks and as thin whole coronal brain slices, in which all the anatomical structures are clearly visible. Separate databases within the Brain Tissue Resource Center contain information on tissue availability, location and investigator allocation.

Other research interests include predictive histological markers of pituitary tumor behavior.

PublicationsBibliography of E. Tessa Hedley-Whyte via PubMed