- Centers & Specialties
- Clinical Interests
- Bone marrow transplantation for hematologic malignancies
- Induction of allotolerance for solid organ transplantation
- Medical Education
- MD, University of Rochester School of Medicine and Dentistry
- Residency, Cornell University Medical Center
- Fellowship, University Hospitals of Cleveland
- Board Certifications
- Internal Medicine
- Medical Oncology
- Boston: Massachusetts General Hospital
- Insurances Accepted
- Aetna Health Inc.
- Beech Street
- Blue Cross Blue Shield - Blue Care 65
- Blue Cross Blue Shield - Indemnity
- Blue Cross Blue Shield - Managed Care
- Blue Cross Blue Shield - Partners Plus
- Cigna (PAL #'s)
- Fallon Community HealthCare
- Great-West Healthcare (formally One Health Plan)
- Harvard Pilgrim Health Plan - ACD
- Harvard Pilgrim Health Plan - PBO
- Health Care Value Management (HCVM)
- Humana/Choice Care PPO
- Medicare - ACD
- Neighborhood Health Plan - ACD
- Neighborhood Health Plan - PBO
- OSW - Connecticut
- OSW - Maine
- OSW - New Hampshire
- OSW - Rhode Island
- OSW - Vermont
- Private Health Care Systems (PHCS)
- Senior Whole Health
- Tufts Health Plan
- United Healthcare (non-HMO) - ACD
- United Healthcare (non-HMO) - PBO
Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.
- Patient Age Group
- Research Summary
- My research interests have focused on the development of non-myeloablative preparative therapy for HLA-matched and mismatched donor transplantation for hematologic malignancy. With this approach, mixed chimerism has been reliably achieved and durable remissions have been demonstrated in patients with chemorefractory malignancy. For the first time, using this technique, sustained mixed lineage lymphohematopoietic chimerism has been induced following HLA haploidentical transplantation, and the results of this experience have been published in multiple journals, including Lancet and Transplantation. In addition, I am working closely with the solid organ transplant program in the development of mixed chimerism transplant strategies for the induction of donor specific allotolerance. From this collaboration, the first successful HLA matched donor bone marrow and kidney transplants for end stage renal disease due to multiple myeloma have been performed. Donor specific tolerance following combined bone marrow and kidney transplantation for renal failure in which there is no underlying malignancy has also been achieved with this strategy. The results of this experience, in which sustained specific tolerance was achieved in 4 of 5 patients, were recently published in the New England Journal of Medicine.
Spitzer TR, Delmonico F, Tolkoff-Rubin N, McAfee S, Sackstein R, Saidman S, Colby C, Sykes M, Sachs DH, Cosimi AB. Combined HLA-matched donor bone marrow and renal transplantation for multiple myeloma with end stage renal disease: The induction of allograft tolerance through mixed lymphohematopoietic chimerism. Transplantation 1999 68; 480-484.
Spitzer TR, McAfee S, Sackstein R, Colby C, Toh HC, Multani P, Saidman S, Weymouth D, Preffer F, Poliquin C, Foley A, Cox B, Dumbkowski D, Andrews D, Sachs DH, Sykes M. The intentional induction of mixed chimerism and achievement of anti-tumor responses following non-myeloablative conditioning therapy and HLA-matched donor bone marrow transplantation for refractory hematologic malignancies. Biol Blood Marrow Transplant 2000; 6:309-320.
Dey B, Spitzer T. Current status of haploidentical stem cell transplantation. Br J Haematol 2006 Br J Haematol 2006; 135: 423-437.
Kawai T, Cosimi AB, Spitzer TR, Tolkoff-Rubin N, Suthanthiran M, Saidman S, Shaffer J, Preffer FI, Ding R, Sharma V, Fishman JA, Dey B, Ko DSC, Hertl M, Goes NB, Wong W, Williams WW, Colvin RB, Sykes M, Sachs DH. HLA-mismatched renal transplantation without maintenance immunosuppression. New Engl J Med 2008; 358: 353-361.
MGHers elevate clinical care in Bangladesh: Bimalangshu Ranjan Dey, MD, of the MGH Cancer Center, begins where his story began &ndash; his birthplace of Bangladesh. Dey left the country when he was 18, but he always believed that one day he would return to use his skills and passion to improve the health and well-being of the people of Bangladesh.
On July 30, MGH faculty and staff gathered under the Bulfinch Tent to celebrate the many contributions of MGH Cancer Center employees and the one hundred 2015 honorees.
Eight years ago, Jennifer Searl used a handicapped permit to get around campus at the University of New Hampshire. Last October, Searl, 26, ran a half-marathon and felt so good afterward she immediately signed up for another. In between these two extremes lies not only a journey of a thousand steps, but one taken along a path Searl herself blazed - with help from the Massachusetts General Hospital Transplant Center.
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