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Marcos F. Vidal Melo, MD, PhD

Direcetor, Cardiac Anesthesia Research

  • Phone: 617-726-8980
Department of Anesthesia, Critical Care and Pain Medicine


  • Heart Center
  • Cardiac Anesthesia
Clinical Interests
Cardiac anesthesia
Pulmonary pathophysiology
Inflammatory response during cardiac surgery
Ventricular assist devices
Boston: Massachusetts General Hospital
Medical Education
MD, Federal Fluminense University
PhD, University of Heidelberg Medical School
Residency, Massachusetts General Hospital
Residency, Southwestern Medical Center
Fellowship, Massachusetts General Hospital
Board Certifications
Anesthesiology, American Board of Anesthesiology
Foreign Languages
Patient Age Group
Accepting New Patients
Accepting New Patients

BiographyThe Laboratory of Applied Biofluids/DACCPM/MGH is the site of most of our research. Our interest is centered in the application of bioengineering techniques to the study of the cardiopulmonary function. In recent years, our focus was the use of mathematical modeling and tracer kinetics analysis to the development of positron emission tomography (PET) techniques to study lung structure, function and inflammation.

Our current efforts are dedicated to two interconnected areas. The first, fundamentally bioengineering based, corresponds to the development of experimental and computational tools for the study of PET images. The second area of study is related to the application of the PET techniques to understand and optimize treatment of experimental and human cardiopulmonary disease.

Our results revealed, for the first time using imaging techniques, the bimodal ventilation-perfusion distributions that are predicted theoretically and obtained experimentally with a standard non-imaging technique (multiple inert gases, MIGET).

Recently, we started projects on Clinical Research in Cardiac Anesthesia. Investigations include:

a) pulmonary function after off-pump and on-pump coronary artery bypass surgery in moderate to severe obstructive pulmonary disease

b) neurocognitive dysfunction after cardiac surgery assessed with Positron Emission Tomography

c) mathematical modeling of the cardiovascular system using radial artery waveforms

d) a phase III drug study in patients with HIT/HITTS Type II undergoing off-pump coronary artery bypass (OPCAB) surgery

e) a multicenter, randomized, parallel-group, placebo-controlled study of 2mg/kg bolus plus 24-hour 0.05 mg/kg/hr infusion of Pexelizumab in patients undergoing coronary artery bypass graft surgery with cardiopulmonary bypass

PublicationsView publications

Massachusetts General Hospital
55 Fruit Street
Boston, MA 02114-2696

Phone: 617-726-8980
Fax: 617-726-5985

Massachusetts General Hospital
55 Fruit Street
Boston, MA 02114-2696

Phone: 617-726-8980
Fax: 617-726-5985

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