Bone metabolism, neuroendocrine alterations in nutritional disorders including anorexia nervosa, athletic amenorrhea and obesity
Ongoing studiesEffect of Growth Hormone on Visceral Fat and Cardiovascular Risk Markers in Obese Teenage Girls
Ackerman KE*, Nazem T*, Chapko C, Russell M, Mendes N, Taylor AP, Bouxsein ML, Misra M. Bone Microarchitecture Is Impaired in Adolescent Amenorrheic Athletes Compared with Eumenorrheic Athletes and Nonathletic Controls. J Clin Endocrinol Metab 2011;96(10):3123-33.
Misra M, Katzman D, Miller KK, Mendes N, Snelgrove D, Russell M, Goldstein M, Ebrahimi S, Clauss L, Weigel T, Mickley D, Schoenfeld D, Herzog DB, Klibanski A. Physiologic estrogen replacement increases bone density in adolescent girls with anorexia nervosa. J Bone Miner Res. 2011;26(10):2430-8.
Walsh CJ, Phan CM, Misra M, Bredella MA, Miller KK, Fazeli PK, Bayraktar HH, Klibanski A, Gupta R. Women with anorexia nervosa: finite element and trabecular structure analysis by using flat-panel volume CT. Radiology 2010;257(1):167-74
Misra M, Parangi S, Ross D, Sadow P, Shailam R. Clinicopathological conference: A 13 year-old girl with an enlarging neck mass. New Eng J Med 2010;363(25):2445-54.
Misra M, Cord J, Prabhakaran R, Miller KK, Klibanski A. Growth hormone suppression after an oral glucose load in children. J Clin Endocrinol Metab. 2007;92(12):4623-9.
Clinical Guidelines and Reports
Geller D, Pacaud D, Gordon CM, Misra M on behalf of the Drug and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society. State of the Art Review: Emerging Therapies: The Use of Insulin Sensitizers in the Treatment of Adolescents with Polycystic Ovary Syndrome (PCOS). Int J Pediatr Endocrinol. 2011 Aug 26;2011:9.
Teenager Dipika Daryanani is combating Cushing's disease with innovative treatment and her multidisciplinary care team at MassGeneral Hospital for Children.
According to a new study accepted for publication in the Journal of Clinical Endocrinology & Metabolism, obese teenage girls with a greater ratio of visceral fat (fat around internal organs) to subcutaneous fat (fat found just beneath the skin) are likely to have lower bone density than peers with a lower ratio of visceral to subcutaneous fat.
Estrogen therapy improves low bone density in teenage girls with anorexia nervosa when given as a patch or at an oral dose close to the form or amount the body makes naturally.
Young female athletes who have stopped menstruating have a weakening in the quality of their bone structure that may predispose them to breaking a bone, despite getting plenty of weight-bearing exercise, a new study finds.
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