Dr. Misra is Chief of the Division of Pediatric Endocrinology at MassGeneral Hospital for Children, Director of the Pediatric Endocrine-Sports Endocrine-Neuroendocrine Laboratory at Mass General, and Professor of Pediatrics at Harvard Medical School.
BiographyDr. Misra completed her fellowship in Pediatric Endocrinology at Massachusetts General Hospital and Masters in Public Health at the Harvard School of Public Health. She is Chief of the Division of Pediatric Endocrinology at MGHfC, Associate Director of the Harvard Catalyst Clinical Research Center (MGH) and Director of the Pediatric Endocrine-Sports Endocrine-Neuroendocrine Laboratory (MGH). Dr. Misra has chaired the Drugs and Therapeutics Committee and the Steering Committee for the Spring Fellow Retreat for the Pediatric Endocrine Society (PES). She is chair of the Research Affairs Council of the PES and an ex-NIH study section member. She has received the John Haddad Young Investigator Award (AIMM-ASBMR), the Janet W. McArthur Award (Women in Endocrinology), the Claflin Distinguished Scholar Award (MGH) and the Rita M. Kelley, MD, Fellowship (MGH).
Dr. Misra specializes in neuroendocrinology and disorders of low bone density. She is internationally known for her research on neuroendocrine, metabolic and bone complications of disorders that span the nutritional spectrum from anorexia nervosa to obesity, as well as autism spectrum disorders, and her work has led to major strides in the clinical management of these conditions. Given her work on reproductive and bone dysfunction in the female athlete, she has been identified as an expert on endocrine issues in exercise induced amenorrhea by the Female Athlete Triad Coalition. Moreover, Dr. Misra has a special clinical interest in pituitary disorders, and her panel includes children with some of the most complex pituitary tumors. She is associated with the multidisciplinary Neuroendocrine Clinical Center at Mass General, and is often asked to provide second opinions on complex pituitary cases managed elsewhere. In addition, Dr. Misra sees children with growth and puberty disorders, reproductive, adrenal and thyroid disorders, as well as children with diabetes and other disorders of carbohydrate metabolism.
Bone metabolism, neuroendocrine alterations in nutritional disorders including anorexia nervosa, athletic amenorrhea and obesity
Ongoing studiesEffect of Growth Hormone on Visceral Fat and Cardiovascular Risk Markers in Obese Teenage Girls
Selected Original Articles (from over 100)
1. Misra M, Katzman DK, Miller KK, Mendes N, Snelgrove D, Russell M, Goldstein MA, Ebrahimi S, Clauss L, Weigel T, Mickley D, Schoenfeld D, Herzog DB, Klibanski A. Physiologic Estrogen Replacement Increases Bone Density in Adolescent Girls with Anorexia Nervosa. J Bone Miner Res 2011;26:2430-8
2. Ackerman KE, Nazem T, Chapko C, Russell M, Mendes N, Taylor AP, Bouxsein ML, Misra M. Bone Microarchitecture is Impaired in Adolescent Amenorrheic Athletes Compared with Eumenorrheic Athletes and Non-Athletic Controls. J Clin Endocrinol Metab 2011;96:3123-33.
Selected Reviews (from over 50)
1. Misra M, Pacaud D, Petryk A, Collett-Solberg P, Kappy M, on behalf of the D&T Committee of the LWPES. Vitamin D Deficiency in Children and its Management: Review of Current Knowledge and Recommendations. Pediatrics 2008; 122: 398-417.
2. Misra M. Effects of Hypogonadism on Bone Metabolism in Adolescent and Young Adult Women. Nature Reviews Endocrinology 2012;8(7):395-404
3. Misra M, Klibanski A. Endocrine Consequences of Anorexia Nervosa. The Lancet Diabetes and Endocrinology. In Press
1. Smith E, Loeffler J, Misra M, Pomerantz S, Stemmer-Rachamimov A, Post M. Case records of the MGH: Case 37-2008. A 17-year-old boy with a pituitary tumor and skull abnormalities. New Eng J Med 2008;359:2367-77
2. Misra M, Parangi S, Ross D, Sadow P, Shailam R. Case records of the MGH: Case 38-2010: a 13-year-old girl with an enlarging neck mass. New Eng J Med 2010;363:2445-54
Teenager Dipika Daryanani is combating Cushing's disease with innovative treatment and her multidisciplinary care team at MassGeneral Hospital for Children.
Madhusmita Misra, MD, MPH, has been named the chief of Pediatric Endocrinology at MassGeneral Hospital for Children (MGHfC), effective July 1, 2015.
According to a new study accepted for publication in the Journal of Clinical Endocrinology & Metabolism, obese teenage girls with a greater ratio of visceral fat (fat around internal organs) to subcutaneous fat (fat found just beneath the skin) are likely to have lower bone density than peers with a lower ratio of visceral to subcutaneous fat.
Estrogen therapy improves low bone density in teenage girls with anorexia nervosa when given as a patch or at an oral dose close to the form or amount the body makes naturally.
Young female athletes who have stopped menstruating have a weakening in the quality of their bone structure that may predispose them to breaking a bone, despite getting plenty of weight-bearing exercise, a new study finds.
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