Ken Solt, MD
Assistant Professor of Anaesthesia, Harvard Medical School Assistant Anesthetist, Massachusetts General Hospital
- Department of Anesthesia, Critical Care and Pain Medicine
- Clinical Interests
- Anesthesia for general surgery and orthopedics
- Obstetric anesthesia
- Boston: Massachusetts General Hospital
- Medical Education
- MD, University of Pennsylvania School of Medicine
- Residency, Massachusetts General Hospital
- Board Certifications
- Anesthesiology, American Board of Anesthesiology
- Foreign Languages
- Accepting New Patients
- Insurances Accepted
- Aetna Health Inc.
Blue Cross Blue Shield - Blue Care 65
Blue Cross Blue Shield - Indemnity
Blue Cross Blue Shield - Managed Care
Blue Cross Blue Shield - Partners Plus
Cigna (PAL #'s)
Fallon Community HealthCare
Great-West Healthcare (formally One Health Plan)
Harvard Pilgrim Health Plan - PBO
Health Care Value Management (HCVM)
Humana/Choice Care PPO
Neighborhood Health Plan - ACD
Neighborhood Health Plan - PBO
OSW - Maine
OSW - New Hampshire
OSW - Rhode Island
Private Health Care Systems (PHCS)
Tufts Health Plan
United Healthcare (non-HMO) - ACD
United Healthcare (non-HMO) - PBO
- Elucidating the mechanisms underlying emergence from general anesthesia
- Actively controlling the process of emergence from general anesthesia
- Developing novel methods to assess return of cognitive function after general anesthesia
- Analysis of neurophysiological recordings during general anesthesia and active emergence
Description of Research
I began investigating anesthetic mechanisms in medical school, where I studied biophysical interactions between halogenated anesthetics and model proteins that mimic putative molecular sites of anesthetic action. As a senior resident and junior faculty member in the Department of Anesthesia, Critical Care and Pain Medicine at MGH, I studied anesthetic-induced changes in the function of neuronal ion channels. For several years I used two-electrode voltage-clamp and patch-clamp electrophysiology with ultra-rapid solution exchange techniques to study ion channel physiology under simulated synaptic conditions.
Since 2008 my laboratory work has focused on investigating the mechanisms of emergence from general anesthesia using a systems neuroscience approach. Evidence suggests that arousal pathways in the brain play important roles in promoting emergence from general anesthesia. My team currently studies these pathways and developing novel methods to actively induce emergence from general anesthesia in surgical patients. In 2011, we published a manuscript describing the active induction of emergence from general anesthesia with methylphenidate in rats, and we are now probing the role of dopaminergic neurotransmission in active emergence. Our work may eventually lead to improved pharmacological control over the arousal states of anesthetized patients, better treatments for emergence delirium, better neurophysiological monitors to detect intraoperative awareness, and ultimately a safer and more efficient practice of anesthesiology.
Administration of the commonly used stimulant drug methylphenidate was able to speed recovery from general anesthesia in an animal study conducted at MGH. The report is the first demonstration in mammals of what could be a safe and effective way to induce arousal from general anesthesia.
The ability of the commonly used stimulant methylphenidate (Ritalin) to speed recovery from general anesthesia appears to apply both to the inhaled gas isoflurane, as previously reported, and to the intravenous drug propofol.
Stimulating one of two dopamine-producing regions in the brain was able to arouse animals receiving general anesthesia with either isoflurane or propofol.
Anesthesia, Critical Care and Pain Medicine
55 Fruit Street
Boston, MA 02114-2696
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