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Ion Alexandru Hobai, MD, PhD

  • Phone: 617-726-3030
Department of Anesthesia, Critical Care and Pain Medicine
Boston: Massachusetts General Hospital
Medical Education
PhD, University of Bristol - England
MD, University of Medicine & Pharmacy, Carol Davila
Residency, Massachusetts General Hospital
Board Certifications
Anesthesiology, American Board of Anesthesiology
Patient Age Group
Accepting New Patients
Accepting New Patients


Research Areas

  • Sepsis
  • Heart failure
  • Heart muscle physiology

Description of Research

My current research focuses on understanding the mechanisms responsible for the decreased cardiac contractile force in patients with sepsis and septic shock (a clinical entity also known as sepsis-induced cardiomyopathy). Specifically, in the last few years I have been studying mechanisms of intracellular calcium homeostasis and nitric oxide (NO) signaling in the heart. NO appears to play a dual role in sepsis, having both pathologic and beneficial roles, and my goal is to be able to propose novel therapeutic agents that will specifically correct the former and potentiate the latter.

Previously, I have been interested in understanding the mechanisms of cardiac excitation contraction coupling (the process that links the cardiac action potential to the development of contractile force, and the main determinant of cardiac contractile force), during my graduate studies in Physiology at the University of Bristol, UK, which were followed by a research fellowship at Johns Hopkins University. At Johns Hopkins I studied how the process of excitation-contraction coupling is compromised in the failing heart, and devised novel therapeutic strategies.  My current interest in sepsis-induced cardiomyopathy is partly the result of my training and current work as a clinical anesthesiologist at Mass General Hospital.


  • Hobai IA, Chhangani SV, Alfille PH. Anesthesia for tracheal resection and reconstruction. Anesthesiol Clin. 2012;30:709-730.
  • Hobai IA, Gauran C, Chitilian HV, Ehrenfeld JM, Levinson J, Sandberg WS. The management and outcome of documented intraoperative heart rate-related electrocardiographic changes. J Cardiothorac Vasc Anesth. 2011;25:791-798.
  • Hobai IA. Letter by Hobai regarding article, "Long-term anabolic-androgenic steroid use is associated with left ventricular dysfunction". Circ Heart Fail. 2011;3:e30; author reply e31.
  • Buys ES, Cauwels A, Raher MJ, Passeri JJ, Hobai I, Cawley SM, Rauwerdink KM, Thibault H, Sips PY, Thoonen R, Scherrer-Crosbie M, Ichinose F, Brouckaert P, Bloch KD. sGC(alpha)1(beta)1 attenuates cardiac dysfunction and mortality in murine inflammatory shock models. Am J Physiol Heart Circ Physiol. 2009;297:H654-663.
  • Hobai IA, Bittner EA, Grecu L. Perioperative spinal cord infarction in nonaortic surgery: report of three cases and review of the literature. J Clin Anesth. 2008;20:307-312.
  • Hobai IA. Atrioventricular block induced by indigo carmine. Can J Anaesth. 2008;55:717-718.
  • Hobai I, O'Rourke B, inventors. U.S. Patent: Method for treating heart failure by inhibiting the sarcolemmal sodium/calcium exchange, 2004.
  • Hobai IA, Maack C, O'Rourke B. Partial inhibition of sodium/calcium exchange restores cellular calcium handling in canine heart failure. Circ Res. 2004;95:292-299.
  • Armoundas AA, Hobai IA, Tomaselli GF, Winslow RL, O'Rourke B. Role of sodium-calcium exchanger in modulating the action potential of ventricular myocytes from normal and failing hearts. Circ Res. 2003;93:46-53.

Selected publications

Anesthesia, Critical Care and Pain Medicine
55 Fruit Street
Boston, MA 02114-2696

Phone: 617-726-3030
Fax: 617-724-8500

Anesthesia, Critical Care and Pain Medicine
55 Fruit Street
Boston, MA 02114-2696

Phone: 617-726-3030
Fax: 617-724-8500

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