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Kevin Joseph Staley, MD

Unit Chief, Pediatric Neurology

  • Phone: 617-726-3877
Departments
Department of Neurology

Specialties

  • MassGeneral Hospital for Children
  • Neurology
Clinical Interests
Epilepsy
Neonatal seizures
Locations
Boston: Massachusetts General Hospital
Medical Education
MD, University of California San Diego Medical School
Residency, University of California San Diego
Residency, University of Colorado Health Science Ctr
Fellowship, Stanford University Medical Center
Board Certifications
Neurology with Special Qualifications in Child Neurology, American Board of Psychiatry and Neurology
Gender
Male
Patient Gateway
Yes, learn more
Patient Age Group
Pediatric
Accepting New Patients
Yes

Biography

Kevin J. Staley

Joseph P. and Rose F. Kennedy Professor of Neurology, Harvard Medical School

Unit Chief, Pediatric Neurology, Mass General Hospital Department of Neurology

Kevin Staley received his MD degree from the University of California, San Diego. He completed his postdoctoral research training at Stanford University School of Medicine. Dr Staley studies neuronal ion transport in neonatal seizures and neural network dysfunction in epilepsy. He has served as Chair of the Investigator's Workshop Committee and the Research and Training Committee of the American Epilepsy Society, as Chair of the Research Council of the Epilepsy Foundation of America, as co-chair of the inaugural Gordon Conference on Mechanisms of Epilepsy and Neuronal Synchronization, and as an Associate Editor for the Journal of Neuroscience.

He is currently the Chief of Pediatric Neurology at Massachusetts General Hospital and the Joseph P. and Rose F. Kennedy Professor of Child Neurology and Mental Retardation, Harvard Medical School.

Research

Pediatric Epilepsy Research Lab

Neurology Research Investigator Profile

Our long-term research goal is the development of new approaches to the treatment of epilepsy based on a clearer understanding of the necessary steps in seizure initiation and propagation.

The two major themes in the lab are neuronal ion transport and the spread of activity in neural networks. Neuronal ion transport underlies signaling at all fast synapses. The importance of neuronal ion transport was underscored by our recent discovery that reversed ion transport in the immature brain was blocking the effects of the anticonvulsants most commonly used to treat neonatal seizures, and that a safe and well-characterized diuretic could ameliorate this condition.

Our work on the spread of excitation in neural networks combines fluorescent imaging of network activity with computerized analysis and modeling to understand how normal and abnormal signaling progresses through neural networks. We have found evidence for reentrant or circular patterns of neural activity that resemble cardiac fibrillation and precede seizures. We are currently testing whether this reentrant activation of neural circuits is the earliest stage of a seizure, and the stage at which intervention is most effective. We are also testing whether long-term reductions in the strength of synaptic connections between neurons in epileptic networks can reduce the probability of seizures.

Publications

View my most recent publications at PubMed

  1. Glykys J, Dzhala V, Egawa K, Balena T, Saponjian T, Kuchibhotla KV, Bacskai BJ, Kahle KT, Zeuthen T, Staley KJ. Local Impermeant Anions Establish the Neuronal Chloride Concentration. Science in press 2014.
  2. Berdichevsky Y, Dryer A, Mahoney M, Pimentel C, Lucini C, Saponjian Y, Usenovic M, and Staley KJ. PI3K-Akt signaling activates mTOR-mediated epileptogenesis in organotypic hippocampal culture model of posttraumatic epilepsy. J Neurosci 33:9056-67, 2013.
  3. Lillis KP, Kramer MA, Mertz J, Staley KJ, White JA. Pyramidal cells accumulate chloride at seizure onset. Neurobiol Dis. 2012 Sep;47(3):358-66.
  4. Sabolek HR, Swiercz WB, Lillis K, Cash SS, Huberfeld G, Zhao G, Ste. Marie L, Clemenceau S, Barsh G, Miles R, Staley KJ: A candidate mechanism underlying the variance of interictal spike propagation. J Neurosci. 32:3009-3021, 2012.

  • Neurology Bicentennial Celebration, 2011 Part I

    Neurology Bicentennial Celebration, October 13, 2011. Past History of MGH Neurology; Overview of MGH Neurology; Telestroke and Acute Stroke Service; Neurodegenerative Disorders; Pediatric Neurology.

    MassGeneral Hospital for Children study explains some mysteries of neonatal seizures

    A study led by MassGeneral Hospital for Children investigators is providing new insight into the mechanism of neonatal seizures, which have features very different from seizures in older children and adults.

    Pediatric Neurology
    55 Fruit Street
    WAC 708-D
    Boston, MA 02114-2696

    Phone: 617-726-3877
    Fax: 617-724-7860

    Pediatric Neurology
    55 Fruit Street
    WAC 708-D
    Boston, MA 02114-2696

    Phone: 617-726-3877
    Fax: 617-724-7860

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