Find a Doctor

Physician Photo

Anthony John Iafrate, MD

Associate in Pathology, Massachusetts General Hospital

Medical Director, Center for Integrated Diagnostics

Associate Professor of Pathology, Harvard Medical School

Dr. Iafrate has helped make solid tumor genotyping for cancer patients available nationally. He is working to make this part of everyday care for cancer patients.

Department of Pathology


  • Cancer Center
  • Thoracic Cancers
  • Targeted Therapies
  • Neuro-Oncology (Brain)
Clinical Interests
Molecular pathology
Boston: Massachusetts General Hospital
Medical Education
MD, PhD, SUNY at Stony Brook School of Medicine
Residency, Brigham and Women's Hospital
Fellowship, Brigham and Women's Hospital
Board Certifications
Anatomic Pathology, American Board of Pathology
Molecular Genetic Pathology, American Board of Medical Genetics
Patient Age Group
Accepting New Patients
Accepting New Patients


Dr. Iafrate is the director of the Center for Integrated Diagnostics, a clinical laboratory for molecular diagnostics at Massachusetts General Hospital. He oversees the Translational Research Laboratory (TRL), a shared effort of the Pathology Department and Mass General Cancer Center. The TRL provides rapid personalized genomic testing to help inform cancer treatment decisions for patients. Dr. Iafrate received his MD, PhD degrees from the State University of New York at Stony Brook in 2000, and was trained in anatomic and molecular genetic pathology at Brigham and Women's Hospital. He joined the Massachusetts General Hospital staff in 2005. His post-doctoral work involved the discovery and description of a novel source of human genetic diversity, termed "copy number variation" (CNV). He established a cancer diagnostics lab focusing on genetic fingerprints that help guide novel, targeted therapies. His laboratory launched SNaPshot several years ago, an assay that tests over 100 of the most common mutations in tumors. His research is focused on lung and brain tumors, and he has been closely involved in the clinical development of crizotinib and companion diagnostics in ALK-positive lung cancers.


Research in the Iafrate laboratory focuses on bringing new genetic technologies to cancer diagnostics and their application to the practice of pathology. Initially research focused on lung cancer, but our approach is expanding to all malignancies. See details at the Iafrate Lab. For more information about research concepts, co-authors, and to see a timeline, visit  Dr. Iafrate's profile at the Harvard Clinical and Translational Science Center.


View my most recent publications at PubMed

  1. Dendritic Cells in Kidney Transplant Biopsy Samples Are Associated with T Cell Infiltration and Poor Allograft Survival. Batal I, De Serres SA, Safa K, Bijol V, Uneo T, Onozato ML, Iafrate AJ, Herter JM, Lichtman AH, Mayadas TN, Guleria I, Rennke HG, Najafian N, Chandraker A. J Am Soc Nephrol. 2015 Apr 8. Epub ahead of print]
  2. RB loss in resistant EGFR mutant lung adenocarcinomas that transform to small-cell lung cancer. Niederst MJ, Sequist LV, Poirier JT, Mermel CH, Lockerman EL, Garcia AR, Katayama R, Costa C, Ross KN, Moran T, Howe E, Fulton LE, Mulvey HE, Bernardo LA, Mohamoud F, Miyoshi N, VanderLaan PA, Costa DB, J?nne PA, Borger DR, Ramaswamy S, Shioda T, Iafrate AJ, Getz G, Rudin CM, Mino-Kenudson M, Engelman JA. Nat Commun. 2015 Mar 11;6:6377.
  3. Multi-institutional Oncogenic Driver Mutation Analysis in Lung Adenocarcinoma: The Lung Cancer Mutation Consortium Experience. Sholl LM, Aisner DL, Varella-Garcia M, Berry LD, Dias-Santagata D, Wistuba II, Chen H, Fujimoto J, Kugler K, Franklin WA, Iafrate AJ, Ladanyi M, Kris MG, Johnson BE, Bunn PA, Minna JD, Kwiatkowski DJ; LCMC Investigators. J Thorac Oncol. 2015 May;10(5):768-77.

Celebrating prize-winning MGH research

The presentation of the MGH's top research prizes was a highlight of the April 13 Celebration of Science, held in conjunction with the annual Scientific Advisory Committee meeting.

Mass. General study finds amplification of multiple cell-growth genes in some brain tumors

A small percentage of the deadly brain tumors called glioblastomas, which usually resist treatment with drugs targeting mutations in cell-growth genes, appears to contain extra copies of two or three of these genes at the same time. The surprising discovery has major implications for the understanding of tumor biology and for targeted cancer therapies.

Mass. General study defines a new genetic subtype of lung cancer

MGH Cancer Center investigators have defined the role of a recently identified gene abnormality – rearrangements in the ROS1 gene – in non-small-cell lung cancer, the leading cause of cancer death in the U.S. They also show that these tumors can be treated with crizotinib and describe the remarkable response of one patient to such treatment.

Pathology Associates
55 Fruit Street
Boston, MA 02114-2696

Phone: 617-726-2967
Fax: 617-726-7474

Pathology Associates
55 Fruit Street
Boston, MA 02114-2696

Phone: 617-726-2967
Fax: 617-726-7474

Request a new patient appointment

Call the Massachusetts General Hospital physician referral service at 800-711-4644.

Insurance plans - what you need to know

Mass General accepts most health insurance plans. Find out what you need to know before coming to Mass General.

Directions to Mass General

Driving to Mass General? Get driving directions or locate a parking lot on the hospital's main campus.