Joren Madsen, MD, DPHL, is Director of the Mass General Transplant Center, Co-Director of the Transplantation Biology Research Center, W. Gerald and Patricia R. Austen Distinguished Scholar in Cardiac Surgery at MGH and Professor of Surgery at HMS


Thoracic Surgery


Centers & Specialties

Heart Center

Transplant Center

Clinical Interests
  • Cardiac (heart) surgery
Medical Education
  • DPHIL, Oxford University
  • MD, University of Massachusetts Medical School
  • Residency, Children's Hospital Boston|Residency, Massachusetts General Hospital
Board Certifications
  • Thoracic Surgery (Cardiothoracic Vascular Surgery)
  • Boston: Massachusetts General Hospital
Insurances Accepted
  • Aetna Health Inc.
  • Beech Street
  • Blue Cross Blue Shield - Blue Care 65
  • Blue Cross Blue Shield - Indemnity
  • Blue Cross Blue Shield - Managed Care
  • Blue Cross Blue Shield - Partners Plus
  • Cigna (PAL #'s)
  • Fallon Community HealthCare
  • Great-West Healthcare (formally One Health Plan)
  • Harvard Pilgrim Health Plan - PBO
  • Harvard Pilgrim Health Plan - SSN
  • Health Care Value Management (HCVM)
  • Humana/Choice Care PPO
  • MassHealth
  • Medicare
  • Neighborhood Health Plan - ACD
  • Neighborhood Health Plan - PBO
  • OSW - Maine
  • OSW - New Hampshire
  • Private Health Care Systems (PHCS)
  • Senior Whole Health
  • TriCare
  • Tufts Health Plan
  • Unicare
  • United Healthcare (non-HMO) - ACD
  • United Healthcare (non-HMO) - PBO

Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.

Patient Age Group

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Joren C. Madsen, MD, DPhil received his bachelor's degree from Brown University and his medical degree from the University of Massachusetts Medical School in 1982. After completing his first three years of general surgery training at Mass General, he was awarded the Claude E. Welch Surgical Research fellowship to study at Oxford University. His work there culminated in a doctorate degree from Balliol College in Immunology. Dr. Madsen completed his surgical residency in 1990 and went on to train in cardiothoracic surgery at Mass General and Boston Children's Hospital. He joined the Division of Cardiac Surgery in 1993.

Currently Dr. Madsen is Professor of Surgery at Harvard Medical School and the W. Gerald and Patricia R. Austen Distinguished Scholar in Cardiac Surgery at Mass General. He directs the Transplant Center, which encompasses kidney, liver, lung, heart, pancreas and small bowel transplantation in adults and children. He is also Co-Director of the Transplantation Biology Research Center (TBRC), a large,  basic and translational research laboratory studying transplantation immunology. Dr. Madsen divides his time between cardiac transplant surgery, transplant immunology research, teaching and administration. His academic interests have focused on transplantation tolerance, chronic rejection and innate immunity. He has a strong commitment to both clinical and scientific education, having mentored over 30 pre- and post-doctoral fellows in his laboratory.

Dr. Madsen serves on the editorial boards of Transplantation, the American Journal of Transplantation and the Annals of Thoracic Surgery. He is currently the past president of the American Society of Transplantation, the first surgeon to be elected to that position.

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Research & Publications

Research Summary

Dr. Madsen leads three interrelated research groups that study the molecular and cellular mechanisms of transplant rejection and immune tolerance in mice, swine and nonhuman primates, respectively. By understanding the biological of these processes Madsen hopes to find ways to prolong organ allograft survival (inducing tolerance), extend transplant recipients lives (preventing chronic rejection) and increase the organ donor pool (pig-to-human xenotransplantation). Dr. Madsen's laboratory has been the first to induce long term tolerance of cardiac allografts in large animals and to demonstrate the natural killer cells contribute to cardiac allograft vasculopathy. He has been continuously funded by the NIH since 1995.

In 2002, he received the Fujisawa Basic Science Award from the American Society of Transplantation. In 2005, he was made the W. Gerald and Patricia R. Austen Distinguished Scholar in Cardiac Surgery at Massachusetts General Hospital. In 2009, he was elected president of the American Society of Transplantation.


View my most recent publications at PubMed


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News & Events


Massachusetts General Hospital
55 Fruit Street
Boston MA, 02114-2696
Phone 1: 617-726-6506
Phone 2: 617-643-4587
Fax: 617-726-4067

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