Sekar Kathiresan, MD, is a cardiologist at the Cardiovascular Disease Prevention Center at the Massachusetts General Hospital Heart Center.



Centers & Specialties

Heart Center

Clinical Interests
  • Family history of heart attack
  • Hyperlipidemia
  • Genetics
  • Preventive cardiology
Medical Education
  • MD, Harvard Medical School
  • Residency, Massachusetts General Hospital
  • Fellowship, Massachusetts General Hospital
Board Certifications
  • Cardiovascular Disease
Foreign Languages
  • Tamil
  • Boston: Massachusetts General Hospital
Insurances Accepted
  • Aetna Health Inc.
  • Beech Street
  • Blue Cross Blue Shield - Blue Care 65
  • Blue Cross Blue Shield - Indemnity
  • Blue Cross Blue Shield - Managed Care
  • Blue Cross Blue Shield - Partners Plus
  • Cigna (PAL #'s)
  • Fallon Community HealthCare
  • Great-West Healthcare (formally One Health Plan)
  • Harvard Pilgrim Health Plan - ACD
  • Harvard Pilgrim Health Plan - PBO
  • Health Care Value Management (HCVM)
  • Humana/Choice Care PPO
  • MassHealth
  • Medicare
  • Medicare - ACD
  • Neighborhood Health Plan - ACD
  • Neighborhood Health Plan - PBO
  • OSW - Maine
  • OSW - New Hampshire
  • OSW - Rhode Island
  • OSW - Vermont
  • Private Health Care Systems (PHCS)
  • Railroad Medicare
  • Railroad Medicare - ACD
  • Senior Whole Health
  • TriCare
  • Tufts Health Plan
  • Unicare
  • United Healthcare (non-HMO) - ACD
  • United Healthcare (non-HMO) - PBO

Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.

Patient Age Group

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Dr. Sekar Kathiresan graduated from North Allegheny High School in Pittsburgh, PA and received his B.A. in history summa cum laude from the University of Pennsylvania in 1992. He received his M.D. from Harvard Medical School in 1997. He completed his clinical training in internal medicine and cardiology at Massachusetts General Hospital. He served as Chief Resident in Internal Medicine at MGH in 2002-2003. Subsequently, he pursued research training in cardiovascular genetic epidemiology through a combined experience at the Framingham Heart Study and the Broad Institute of Harvard/MIT, mentored jointly by Drs. Christopher J. O'Donnell and Joel N. Hirschhorn. In addition to his research efforts, Dr. Kathiresan is Director of Preventive Cardiology at MGH and has a clinic focused on primary prevention of myocardial infarction in individuals with a family history of heart attack.

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Research & Publications

Research Summary

Lab Overview

Altered blood lipids predict risk of myocardial infarction and myocardial infarction is the leading cause of death worldwide. Both blood lipid levels and myocardial infarction are heritable phenotypes. The genes underlying the variability in blood lipids and risk of myocardial infarction are largely unknown. Genes validated in the human population to relate to blood lipids and to risk of myocardial infarction may provide novel diagnostics and new therapeutic targets.

My laboratory seeks to define the genetic basis for blood lipids (high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides) and myocardial infarction (MI). We are focused on three goals: 1) mapping of genetic loci related to lipids and/or myocardial infarction and identifying the causal variants and genes; 2) developing a molecular understanding of how the causal variants and genes lead to phenotype; and 3) applying genetic and functional insights to improve preventive cardiac care. To address the above goals, my laboratory uses a variety of research methodologies and reagants including population genetics, large patient sample collections, genetic association, functional analysis in model organisms, and genetic studies in clinical trials and prospective cohort studies.


View my most recent publications at PubMed

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News & Events



Cardiovascular Disease Prevention Center
25 New Chardon Street
Suite 301
Boston MA, 02114-4774
Phone 1: 617-726-9292
Phone 2: 617-643-1455
Fax: 617-724-6767

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