Find a Doctor

Physician Photo

Yi-Bin Albert (Yi-Bin) Chen, MD

Currently, Dr. Chen divides his time between patient care and clinical research with a focus on patients undergoing bone marrow / stem cell transplantation. He invites you to contact him directly with any questions.

  • Phone: 617-724-1124
Department of Medicine


  • Cancer Center
  • Leukemia
  • Bone Marrow Transplant
Clinical Interests
Bone marrow, Stem cell, Cord blood transplant
Acute and chronic leukemia
Hodgkin's and Non-Hodgkin's lymphoma
Multiple myeloma
Aplastic anemia
Myelodysplastic syndrome (MDS)
Boston: Massachusetts General Hospital
Medical Education
MD, Harvard Medical School
Residency, Massachusetts General Hospital
Fellowship, Dana Farber Cancer Institute
Board Certifications
Internal Medicine, American Board of Internal Medicine
Medical Oncology, American Board of Internal Medicine
Patient Gateway
Yes, learn more
Patient Age Group
Accepting New Patients
Accepting New Patients

BiographyYi-Bin Chen grew up in New Jersey.  He majored in molecular biology at Yale University before attending medical school at Harvard Medical School.  Subsequently, he did his internship and residency at Massachusetts General Hospital including an additional year as chief resident and a fellowship in hematology / oncology at the Dana-Farber Partners combined program.  In 2008, he joined the staff of the Bone Marrow Transplant Unit and Center for Leukemia at the MGH Cancer Center.  His interests mainly revolve around taking care of patients underoing autologous and allogeneic stem cell transplant as well as continuing his active role in clinical trials.  He currently lives in Needham, MA with his wife and 2 children.   

ResearchDr. Chen is the Director of Clinical Research for the BMT program at MGH.  His research interests mainy revolve around improving the outcomes for patients undergoing autologous and allogeneic stem cell transplantation.  He serves as institution and overall principal investigator for many clinical trials.  MGH is an active participant in several national collaborative group trials, specifically from Alliance and the BMT CTN.  In addition, Dr. Chen currently has several of his own investigator-initiated clinical trials open with mulitple others in development.  These include:
1. A novel high dose chemotherapy regimen followed by autologous stem cell transplantation for patients with central nervous system (CNS) involvement by lymphoma.

2. A novel approach using tandem autologous stem cell transplant followed by reduced intensity allogeneic stem cell transplant for patients with high-risk lymphoma.

3. A novel reduced intensity conditioning regimen comprised of busulfan with clofarabine for patients undergoing reduced intensity allogeneic stem cell transplantation.

4. Use of sorafenib as maintenance chemotherapy after allogeniec stem cell transplantation for FLT3-ITD mutate AML

5. Use of brentuximab vedotin to target CD30 in the treatment of acute graft-vs-host disease (GVHD)

6. Combined bone marrow and kidney transplantation using partially matched family donors

Dr. Chen invites you to contact him directly to inquire about the latest clnical investigations available at MGH. 

PublicationsChen YB, Aldridge J, Kim HT, et al..  Biol of Blood and Marrow Transplantat. 2012;18(5):805-12.

Chen YB, McDonough S, Hasserjian R, et al.  Blood. 2012; 120(3):691-6.

Chen YB, Kim H, McDonough S, et al.@Upregulation of a4b7 integrin on peripheral blood memory T-cells predicts for intestinal graft-versus-host disease (GVHD) following allogeneic stem cell transplantation. Biol of Blood and Marrow Transplant. 2009;15:1066-76.

Chen YB and Spitzer TR. "Current status of reduced intensity transplantation using alternative donors." Leukemia. 2008;22:31-41.

Hematology/Oncology BMT Program
100 Blossom Street
Boston, MA 02114-2606

Phone: 617-724-1124
Fax: 617-643-5843

Hematology/Oncology BMT Program
100 Blossom Street
Boston, MA 02114-2606

Phone: 617-724-1124
Fax: 617-643-5843

Request a new patient appointment

Call the Massachusetts General Hospital physician referral service at 800-711-4644.

Insurance plans - what you need to know

Mass General accepts most health insurance plans. Find out what you need to know before coming to Mass General.

Directions to Mass General

Driving to Mass General? Get driving directions or locate a parking lot on the hospital's main campus.