Overview

Dr. Eric Pierce is a full-time clinician scientist. He is the Director of the Inherited Retinal Disorders Service and the Berman-Gund Laboratory for the Study of Retinal Degenerations, the Director of the Ocular Genomics Institute at Mass. Eye and Ear, and the Solman and Libe Friedman Associate Professor of Ophthalmology at Harvard Medical School.

Departments

Ophthalmology

Clinical Interests
  • Retina
  • Retinal degenerations
Medical Education
  • MD, Harvard Medical School
  • PhD, University of Wisconsin - Madison
  • Residency, Massachusetts Eye and Ear Infirmary
  • Fellowship, Children's Hospital Boston
Board Certifications
  • Ophthalmology
Foreign Languages
  • Spanish
Locations
  • Boston: Massachusetts Eye and Ear Infirmary
  • Boston: Massachusetts General Hospital
Insurances Accepted
  • Blue Cross Blue Shield - Blue Care 65
  • Blue Cross Blue Shield - Indemnity
  • Blue Cross Blue Shield - Managed Care
  • Blue Cross Blue Shield - Partners Plus
  • Harvard Pilgrim Health Plan - other
  • Senior Whole Health
  • Tufts Health Plan

Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.

Patient Age Group
Adult
Gender
Male

Edit Profile

Biography

Dr. Eric Pierce is a full-time clinician scientist. He is the Director of the Inherited Retinal Disorders Service and the Berman-Gund Laboratory for the Study of Retinal Degenerations, the Director of the Ocular Genomics Institute at Mass. Eye and Ear, and the Solman and Libe Friedman Associate Professor of Ophthalmology at Harvard Medical School.

As a group, retinal degenerations are a common cause of blindness. The overall goal of Dr. Pierce's clinical and research program has been to improve the understanding of the molecular bases of inherited retinal degenerations and related cilia disorders so that rational therapies can be developed for these diseases.

Dr. Pierce pursues his objectives through a combination of laboratory-based investigation of retinal biology and disease, clinical care of children and adults with retinal degenerative disorders, and clinical research. Dr. Pierce is currently working to develop gene therapy for several forms of retinal degeneration.

Edit Profile

Research & Publications

Research Summary

Dr. Pierce is an ophthalmologist and molecular geneticist whose research program is dedicated to understanding the molecular mechanisms of Inherited retinal degenerations (IRDs) and improving therapeutic interventions for these conditions. IRDs are a leading cause of blindness worldwide, and are characterized by progressive dysfunctionand death of retinal photoreceptor cells. Dr. Pierce's research program is focused on identifying new IRD disease genes, investigating the mechanism by which mutations in the identified genes lead to blindness, and using this information about disease pathogenesis to develop gene and genetic therapies to prevent vision loss.

Publications

View my most recent publications at PubMed

Liu Q, Tan G, Levenkova N, Li T, Pugh EN Jr, Rux JJ, Speicher DW, Pierce EA. The proteome of the mouse photoreceptor sensory cilium complex. Mol Cell Proteomics. 2007 Aug; 6(8): 1299-317.

Simonelli F, Maguire AM, Testa F, Pierce EA, Mingozzi F, Bennicelli JL, Rossi S, Marshall K, Banfi S, Surace EM, Sun J, Redmond TM, Zhu X, Shindler KS, Ying GS, Ziviello C, Acerra C, Wright JF, McDonnell JW, High KA, Bennett J, Auricchio A. Gene therapy for Leber's congenital amaurosis is safe and effective through 15 years after vector administration. Mol Ther. 2010 Mar; 18(3): 643-50.

Graziotto JJ, Farkas MH, Bujakowska K, Deramaudt BM, Zhang Q, Nandrot EF, Inglehearn CF, Bhattacharya SS, Pierce EA. Three gene-targeted mouse models of RNA splicing factor RP show late-onset RPE and retinal degeneration. Invest Ophthalmol Vis Sci. 2011 Jan; 52(1): 190-8.

Grant GR, Farkas MH, Pizarro AD, Lahens NF, Schug J, Brunk BP, Stoeckert CJ, Hogenesch JB, Pierce EA. Comparative analysis of RNA-Seq alignment algorithms and the RNA-Seq unified mapper (RUM). Bioinformatics. 2011 Sep 15; 27(18): 2518-28.

Edit Profile

Contact

Massachusetts Eye and Ear Infirmary
243 Charles Street
Boston, MA 02114 - 3002
Phone 1: 617-573-3202
Phone 2: 617-573-6917
Fax: 617-573-3661

Edit Profile