Reproductive Endocrinology and Infertility
The goal of the Massachusetts General Hospital Fellowship in Reproductive Endocrinology and Infertility is to train subspecialist in Obstetrics and Gynecology to manage complex clinical problems relating to Reproductive Endocrinology and Infertility, as well as an emphasis to investigate important relevant basic science, translational, and clinical research questions in this area.
Reproductive Endocrinology and Infertility
The Mass General REI fellowship accepts one fellow every year, for a three-year training period. The fellowship training is divided equally between clinical and research activities. Formal didactic sessions include enrollment in courses and attendance at weekly rounds and conferences. The clinical activities take place primarily in Division of Reproductive Medicine and In-Vitro Fertilization in the Department of Obstetrics and Gynecology at the Massachusetts General Hospital. The basic scientific research activities occur primarily within the Vincent Center for Reproductive Medicine.
The objectives of our program are:
- To provide the highest quality of clinical care for our patients with reproductive endocrine, infertility and other disorders related to reproductive health.
- To be exemplars of education in academic medicine by being outstanding teachers.
- To train and educate our fellows in clinical care, reproductive surgery, research and teaching and promote excellence in future careers in the specialty.
- To conduct basic and clinical research with the goal of advancing the discipline of reproductive biology and surgery and translating these developments to the clinical arena.
The first year is devoted exclusively to research with the faculty of the Vincent Center for Reproductive Biology (VCRB) to learn the basic research skills required to address important issues in reproductive biology. The breadth of investigation available in the VCRB will cover all facets of reproduction and reproductive endocrinology, the utilization of in vitro and in vivo models, and the practice of a full range of molecular techniques. Notably, fellows are given the opportunity to design, implement, and critically review basic research projects with the potential for relevant clinical applications. In addition, graduate level courses related to basic or clinical research will be completed.
During the second year of the MGH REI Fellowship, the fellow will continue research projects initiated in Year 1, but now will focus on clinical activities. The fellow will learn to evaluate and treat medical problems including infertility, polycystic ovarian syndrome, hirsutism, premature ovarian failure, endometriosis, dysfunctional uterine bleeding, and issues related to menopause. The fellow will participate daily in the MGH Fertility Center, learning the skills of assisted reproduction including transvaginal ultrasonography, gonadotropin management, and oocyte retrieval as well as intrauterine insemination, embryo transfer, office hysteroscopy and sonohysterogram.
The fellow will observe in the Embryology Laboratory as well, learning gamete biology and handling, including exposure to micromanipulation. The fellow will attend several weekly clinical conferences
During the third year of the MGH REI Fellowship, the fellow will continue ongoing basic and clinical research projects as well as the bimonthly-supervised REI continuity clinic and all important REI inpatient consults. A major focus of Year 3 will be training in the surgical techniques critical to the specialty, principally endoscopic procedures including robotic surgery. Hands-on training is provided in the department's simulation center, where box trainers and laparoscopic simulators provide basic skills such as camera control, hand-eye coordination, tissue grasping, and suturing skills. The fellow will assist with surgical cases several days weekly. In addition, rotations each of approximately two months duration will be arranged in the related fields of pediatric endocrinology, medical and neuroendocrinology, male infertility, menopause, genetics and directed didactic teaching sessions in endocrine assays and reproductive pathology. While on each subspecialty rotation, the fellow will participate in relevant conferences, rounds, and clinics.
The third year fellow is expected to assume a leadership role within the program and facilitate communication between the fellows and the rest of the team. Administrative responsibilities include coordinating the call schedule, M&M Grand Rounds, and updating the shared Fellow's Drive (network drive) with important dates, call schedules, clinic schedules and any other educational or clinical items that are appropriate. During candidate interviews, the third year fellow is responsible for coordinating the presentation, tour and other fellow activities for the day. Our goal is to evolve the third year fellow as a junior faculty member of academic practice with progressive responsibility clinically and administratively throughout the three year fellowship culminating in third year.
The MGH Fertility Center is located on the 10th floor of the Yawkey Center for Outpatient Care, New England's largest ambulatory care center. The building includes state-of-the art facilities to house the entire Reproductive Medicine and IVF Unit. The Reproductive Medicine and IVF Division provides fertility services in an environment that was specially designed to ensure couples the most modern technology and the utmost in comfort, convenience and confidentiality. It encompasses 10,254 square feet with a state-of-the-art embryology laboratory, private offices for physicians and dedicated workspace for nursing staff. It also features fully equipped procedure and recovery rooms that offers couples greater intimacy and privacy. The space promotes continuity of care and supports our goal of delivering individualized patient care.
Collaborating with us in the delivery of care are Mass General anesthesiologists who attend all IVF procedures and Dr. Cori Tanrikut, a Mass General urologist who specializes in male factor infertility. She provides reproductive urology expertise to the division as a full-time REI faculty member and trains fellows in male infertility including the third year fellow during a two-month rotation.
The Vincent Center for Reproductive Biology (VCRB) laboratories are located on the 9th floor of the Their Building. The VCRB facility encompasses approximately 8,200 sq/ft (the entire 9th floor). This space includes the VCRB administration, conference room, faculty offices and research lab. The space has been completely renovated and the laboratory itself has been equipped with state of the art research equipment.
The principal faculty for the MGH REI Fellowship are Isaac Schiff, M.D., Chief of the Vincent Obstetrics and Gynecology Service; Thomas Toth, M.D., Director, Vincent IVF Unit and Director, Vincent REI Fellowship Program; Jan Shifren, M.D., Director of the Vincent Menopause Program; John Petrozza, M.D., Chief, Reproductive Medicine and IVF; Mitchell S. Rein, MD, Chief Medical Officer/Sr. V.P. Medical Affairs NSMC; Robert McInnes, M.D., Reproductive Endocrinologist; Irene Souter, M.D., Reproductive Endocrinologist; Aaron Styer, MD, Reproductive Endocrinologist; Mary Sabatini, M.D., Ph.D., Reproductive Endocrinologist; Cigdem Tanrikut, MD, Director, Male Reproductive Medicine; Diane Wright, Ph.D., Director of the Vincent Embryology Laboratory; Bo R. Rueda, Ph.D., Associate Professor and Director of the Vincent Center for Reproductive Biology.;
Vincent Center for Reproductive Biology
The Vincent Center for Reproductive Biology is a state-of-the-art research facility that was developed in 1995 to serve as a nucleus of scientific endeavors of the Department. Since its inception, the Center has been successfully nurtured into the Department’s cornerstone for research related to reproductive and women’s health issues. This accomplishment, along with the preexisting strength and research found in other divisions within our Department has combined to make our research enterprise a critical and accomplished component of the MGH Vincent REI Fellowship training program educational goals of basic and translational research of our fellows and their future academic careers. Our overall research mission is to overcome infertility, improve healthcare both for non-pregnant and pregnant women, and ease the menopausal transition in women, with basic, translational, and clinical research.
VCRB Clinical Fellows Research Program
Dr. Bo R. Rueda (Director of the VCRB) developed a Clinical Fellows Research Program in 2001 within the VCRB under the guidance of Dr. Isaac Schiff (Chief of Obstetrics and Gynecology) to provide clinicians an opportunity to develop their academic/research skills. The VCRB provides a unique environment that exposes clinicians to an integrated clinical and basic research program. There are numerous projects ongoing within the VCRB with emphasis on ovarian and uterine cancer, fetal/maternal interactions, menopause, infertility and ovarian cell signaling. Our goal is to provide each Clinical Research Fellow with the opportunity to design, implement and critically review basic research projects on clinically important topics.
Moreover, we encourage all Fellows to present their findings at local and international scientific meetings. While the Fellows are encouraged to be involved in multiple projects, each Fellow has his/her own unique project designed to generate a publication, which will be defended at the end of the Fellowship period. All Clinical Research Fellows work side by side with visiting scientists, Postdoctoral Fellows and students who are here to gain further knowledge in basic and clinical sciences related to reproduction.
In addition to their education in concepts, experimental design and laboratory techniques all Fellows are provided with weekly lectures designed to enhance their understanding of molecular biological techniques and their application to clinical practice. Moreover, they attend weekly laboratory meetings to discuss the projects they are directly involved in as well as the projects of others in the lab. These same meetings include oral presentations by all members involved that cover a variety of topics, such as new techniques or ideas, journal articles, or current conceptual paradigms related to work ongoing in the VCRB.
All graduates of U.S. accredited or osteopathic medical schools that have completed a four-year residency in an ACGME-accredited residency in obstetrics and gynecology are invited to apply. Applicants must be U.S. citizens or permanent residents in good standing in the community in order to be considered for fellowship. The REI Fellowship Program is a member of the National Resident Matching Program (NRMP) and complies with and follows the NRMP guidelines. Applicants must register with the NRMP.
Applications are accepted through the Society for Reproductive Endocrinology and Infertility (SREI) website at http://www.socrei.org/REIApplication/ In addition, we require submission of our internal application, which may be obtained by emailing our program coordinator, Stacy Cohen at firstname.lastname@example.org .
Our application deadline is the first Monday in June of any given year for fellowship commencing the following year on July 1. Fellowship interviews will be conducted on one dates in August to be announced.
Massachusetts General Hospital Fertility Center
55 Fruit Street, Suite Yawkey 10A
Boston, MA 02114
Fellowship Program Director
Thomas Toth, MD
Fellowship Program Coordinator