The Boston NETT Group is a local consortium of hospitals dedicated to offering patients the most cutting edge clinical trials in neurologic emergencies.
Welcome to the Boston NETT Group
The Boston Neurological Emergencies Treatment Trials (Boston NETT) Group is a team of local hospitals participating in a national, federally-funded research effort to develop new treatments for patients with acute diseases and injuries to the brain, spinal cord, and peripheral nervous system. Current and future NETT research studies aim to improve care for patients with stroke, traumatic brain injury, and spinal cord injury. Rapid diagnosis and early treatment are critical for improving outcomes in patients with neurologic emergencies, and the NETT will therefore conduct these studies on the front lines of emergency medicine, in cooperation with colleagues in neurology, neurosurgery, critical care, pre-hospital care, and trauma.
This is an exciting opportunity to improve patient care in the emergency setting. We appreciate your interest, participation, and feedback. Welcome to the Boston NETT Group!
Joshua Goldstein, MD, PhD
The Boston NETT Group
Massachusetts General Hospital
Beth Israel Deaconess Medical Center
Boston Children’s Hospital
Boston Medical Center
Brigham and Women’s Hospital
Newton Wellesley Hospital
Tufts Medical Center
Yale-New Haven Hospital
Current NETT studies
These clinical trials are currently enrolling patients at NETT sites nation-wide.
ATACH II - Antihypertensive Treatment of Acute Cerebral Hemorrhage
This study aims to find the best treatment for high blood pressure in patients with an acute hemorrhagic stroke.
POINT – Platelet Oriented Inhibition in New TIA
Transient ischemic attacks (TIA) are common, with an estimated 250,000-350,000 occurring each year in the US. Patients with TIA often have rapid recovery of blood flow to the brain, which makes TIA different from completed stroke, where recovery is much longer. Many studies have shown that the short-term risk of stroke is high after TIA, particularly in the first few days, even in patients treated with aspirin, which is the current standard of care. Additional effective therapies in those with TIA could significantly reduce the overall burden of stroke if they are started right away. However, no large-scale research study has tested the safety or effectiveness of an acute treatment in patients with TIA. The POINT study aims to determine whether clopidogrel (Plavix) is effective in reducing the 90-day risk of stroke, myocardial infarction (heart attack), and ischemic vascular death when begun within 12 hours of TIA onset in patients taking aspirin.
SHINE – Stroke Hyperglycemia Insulin Network Effort
SHINE aims to determine the most effective and safest way to control blood sugar levels in patients with an acute stroke and high blood sugar. Patients who enroll in SHINE will receive either insulin intravenous (IV) infusion (in the study treatment group) or saline (salt water) infusion with insulin injections (in the study control group) within 12 hours of the start of their stroke symptoms. Patients who enroll in the study will have their neurological outcomes measured 90 days after their stroke, using an exam called the modified Rankin Scale (mRS) score. To determine the effectiveness of the treatments, study doctors will compare the 90-day mRS scores of the study treatment and control groups. To determine the safety of the treatments, the study doctors will look at the rates of low blood sugar and worsening neurological outcomes that occur in both the study treatment and control groups.
Future NETT Studies
ESETT - The Established Status Epilepticus Treatment Trial
ESETT will compare the effectiveness of three different medications in treating patients with continuous seizure activity that does not stop, a condition known as status epilepticus. Patients will receive either fos-phenytoin (also known as Cerebyx, or Prodilantin), valproic acid (also known as Depakote), or levetiracetam (also known as Keppra). ESETT will use a special set of rules called Exception From Informed Consent (EFIC) for emergency research.
For information about EFIC rules and the ESETT study at MGH, please click here: Mass General proposes new treatment trial for patients with severe seizures.
You can also visit the ESETT national study website for more information.
Completed NETT studies
ProTECT III: Progesterone for the Treatment of Traumatic Brain Injury
The results of this NETT study were recently published in the New England Journal of Medicine. You can read about them here.