Center for Neurologic Emergencies

Center for Neurologic Emergencies

The Center for Neurologic Emergencies at Massachusetts General Hospital is dedicated to improving the care of patients with potentially devastating neurological injuries through coordinated educational, research, and quality improvement initiatives within the Department of Emergency Medicine.

About this Program

Diseases of and injuries to the brain and nervous system represent a tremendous health problem for society. Stroke, for example, is the leading cause of disability in the United States, and one of the leading causes of death worldwide. Rapid diagnosis and early treatment are critical for improving outcomes. The Center for Neurologic Emergencies (CNE) aims to both generate new therapies and to educate frontline providers in early recognition and treatment.

The Major Goals of the Center are:

  • To perform early stage research and clinical trials, to bring new therapies to the bedside and improve outcomes.
  • To educate present-day and future emergency providers on the best practices for diagnosis and emergency care.
  • To develop best practices for clinical care, ensuring that all victims of neurologic injury receive the highest quality care available.

Cooperation and collaboration with other groups are at the core of the Center's philosophy. We partner with the Division of Neurocritical Care and Neurologic Emergencies in the Department of Neurology, the Division of Neuroradiology in the Department of Radiology, the Division of Trauma, Emergency Surgery and Surgical Critical Care in the Department of Surgery, and the Department of Neurosurgery.  Our partnerships ensure an interdisciplinary approach to our goals of research, education, and quality improvement.

Joshua Goldstein, MD, PhD
Joshua Goldstein, MD, PhD, Director, Center for Neurologic Emergencies

Educational Opportunities

The Center publishes reviews and book chapters. We lecture nationally and internationally on the care of patients with neurologic emergencies. The Center offers educational sessions, lectures and training to fellows, residents, nurses, and midlevel providers. In collaboration with Beth Israel Deaconess Medical Center, we provide an annual continuing medical education course for frontline providers focused on the care of patients with neurologic emergencies. More information regarding the CME course can be found here.

The Center also supports the advanced training and development of physicians interested in neurologic emergencies and stroke through close collaboration with the J. Philip Kistler Stroke Research Center and Department of Neurology. One and two-year fellowships with a potential masters degree in public health offered by the Harvard School of Public Health are available to competitive applicants. Those interested in fellowship opportunities should contact Melissa Howell at


Please read below and follow the links to learn more about the Center's research projects.

Ongoing Research

  • SCORE-IT: This NIH-funded study is examining whether certain findings on CT scans predict which patients with intracerebral hemorrhage will benefit from blood pressure management.
  • ATACH-II: We are participating in this multicenter trial that aims to find the best treatment for high blood pressure in patients with an acute hemorrhagic stroke.
  • STOP-IT: We are participating in this multicenter trial that is determining whether certain patients with hemorrhagic stroke will benefit from acute hemostatic therapy.
  • ReSET: Many patients who suffer acute bleeding while taking blood thinners require emergency reversal of their medicine to stop the bleeding. We are examining which therapies may help the most for these patients. 
  • iDEF: We are taking part in this study to find out whether treatment with an iron chelator called Deferoxamine Mesylate improves the outcome of patients with bleeding in the brain.

Boston Neurological Emergencies Treatment Trials (NETT) Group

NETT logo

The NETT is a federally-funded consortium of academic medical centers across the United States who work together on specific research projects related to neurologic emergencies. In partnership with Brigham & Women's Hospital, Boston Medical Center, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Yale-New Haven Hospital, Newton-Wellesley Hospital, and Tufts Medical Center, we created the Boston NETT Group, a local consortium dedicated to coordinating efforts to offer patients the most cutting edge clinical trials in neurologic emergencies.

Past Research

Review past publications

Contact Us

Joshua N. Goldstein, MD, PhD
Assistant Professor, Harvard Medical School
Director, Center for Neurologic Emergencies
Department of Emergency Medicine
Massachusetts General Hospital
Zero Emerson Place, Suite 3B
Boston, MA 02114
Phone: 617-724-3290

Melissa Howell
Program Manager, Center for Neurologic Emergencies
Project Manager, Boston Neurological Emergencies Treatment Trials (NETT) Group
Department of Emergency Medicine
Massachusetts General Hospital
5 Emerson Place, Suite 155
Boston, MA 02114
Phone: 617-726-4597

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