Associate Professor of Anaesthesiology, Harvard Medical School
BiographyI have been a member of the Harvard Medical School community as a student, clinician, researcher, and teacher. My current roles include Staff Anesthesiologist at MGH, Investigator on several NIH-sponsored basic research grants, Ad hoc reviewer for NIH grants (Surgery Anesthesia and Trauma study section), OR Staff Administrator, Member of the DACCPM Research Council, Subcommittee Chair for HST medical admissions, Co-director of HST150 (Principles of Clinical Pharmacology), and several scientific subcommittees of the American Society of Anesthesiologists. I am an Associate Professor of Anaesthesiology at Harvard Medical School and an Associate Anesthetist at MGH.
BA-- Chemistry, Wesleyan University
MD-- HMS/MIT Health Sciences and Technology Division
PhD-- Biophysics, Harvard University
Internship-- Internal Medicine, Beth Israel Hospital, Boston
Residency-- Anesthesiology, Mass General Hospital
Fellowship-- Neurobiology, Harvard Medical School
My research aims are to understand where and how general anesthetics act at the molecular level in order to help design better drugs for use in clinical settings. The molecular targets studied are anesthetic sensitive pentameric ligand-gated ion channels, including g-aminobutyric acid-A (GABAA), glycine, nicotinic acetylcholine, and serotonin receptors. Of greatest interest are potent intravenous agents including etomidate, propofol, alphaxalone, and barbiturates. We express cloned channels in cells and use electrophysiological methods to study channel function. We developed a unique 'artificial synapse' technique for high-resolution kinetic studies. Based on an allosteric co-agonist mechanism that we established for etomidate and propofol, we conduct structure-function studies in mutant receptors. We are also mapping out binding sites for anesthetics using substituted cysteine accessibility methods that combine electrophysiology with real-time chemical modification of receptors. In collaboration with Keith Miller, DPhil and Doug Raines, MD, my group also contributes to research on new photo-reactive general anesthetics, production of GABAA receptor protein for photolabeling, and development of new general anesthetics for clinical use.
Phone 2: 617-726-3030