Endocrine Unit

Physician Photo

Stuart A. (Stu) Forman, MD, PhD

Associate Anesthetist

OR Staff Administrator

Associate Professor of Anaesthesiology, Harvard Medical School

  • Phone: 617-726-8822
Departments
Department of Anesthesia, Critical Care and Pain Medicine
Clinical Interests
Combined epidural and general anesthesia
Anesthesia for abdominal surgery
Anesthesia for bariatric surgery
Thoracic and regional anesthesia
Vascular anesthesia
Locations
Boston: Massachusetts General Hospital
Medical Education
MD, PhD, Harvard Medical School
Residency, Massachusetts General Hospital
Fellowship, Massachusetts General Hospital
Board Certifications
Anesthesiology, American Board of Anesthesiology
Gender
Male
Patient Age Group
Adult
Accepting New Patients
Yes

BiographyI have been a member of the Harvard Medical School community as a student, clinician, researcher, and teacher.  My current roles include Staff Anesthesiologist at MGH, Investigator on several NIH-sponsored basic research grants, Ad hoc reviewer for NIH grants (Surgery Anesthesia and Trauma study section), OR Staff Administrator, Member of the DACCPM Research Council, Subcommittee Chair for HST medical admissions, Co-director of HST150 (Principles of Clinical Pharmacology), and several scientific subcommittees of the American Society of Anesthesiologists. I am an Associate Professor of Anaesthesiology at Harvard Medical School and an Associate Anesthetist at MGH.

BA-- Chemistry, Wesleyan University
MD-- HMS/MIT Health Sciences and Technology Division
PhD-- Biophysics, Harvard University
Internship-- Internal Medicine, Beth Israel Hospital, Boston
Residency-- Anesthesiology, Mass General Hospital
Fellowship-- Neurobiology, Harvard Medical School

Research

Research Areas

  • Molecular Mechanisms of General Anesthetics
  • Structure and Function of Ligand-gated Ion Channels
  • Allosteric Drug Mechanisms
  • Kinetic Models for Ion Channel function
  • New General Anesthetic Drug Development

Description of Research

My research aims are to understand where and how general anesthetics act at the molecular level in order to help design better drugs for use in clinical settings. The molecular targets studied are anesthetic sensitive pentameric ligand-gated ion channels, including g-aminobutyric acid-A (GABAA), glycine, nicotinic acetylcholine, and serotonin receptors. Of greatest interest are potent intravenous agents including etomidate, propofol, alphaxalone, and barbiturates. We express cloned channels in cells and use electrophysiological methods to study channel function. We developed a unique 'artificial synapse' technique for high-resolution kinetic studies.  Based on an allosteric co-agonist mechanism that we established for etomidate and propofol, we conduct structure-function studies in mutant receptors. We are also mapping out binding sites for anesthetics using substituted cysteine accessibility methods that combine electrophysiology with real-time chemical modification of receptors. In collaboration with Keith Miller, DPhil and Doug Raines, MD, my group also contributes to research on new photo-reactive general anesthetics, production of GABAA receptor protein for photolabeling, and development of new general anesthetics for clinical use.

Massachusetts General Hospital
55 Fruit Street
Boston, MA 02114-2696

Phone: 617-726-8822
Phone 2: 617-726-3030
Fax: 617-724-8644