Scott B. Snapper, M.D., Ph.D.
Associate Chief of Research, |  |
| Patient Appointments: | (617) 724-3342 |
| Academic Phone: | (617) 724-8977 |
| Fax: | (617) 726-3080 |
| E-Mail: | ssnapper@partners.org |
| Clinical Background: | |
| MD Degree: | Albert Einstein College of Medicine, 1990 |
| Residency: | Brigham and Women's Hospital, 1993 |
| Fellowship: | Massachusetts General Hospital, 1997 |
| Board Certifications: | Internal Medicine, 1993 Gastroenterology, 1997 |
Clinical Interests:
- Inflammatory Bowel Disease
- Mucosal Immune Disorders
- Viral Hepatitis
- Gastrointestinal Malignancies
- General Gastroenterology
Recent Publications:
- Snapper, S.B., Rosen, F.S., Mizoguchi, E., Cohen, P, Khan, W., Liu, C.-H., Hagemann, T., Kwan, S.-P., Ferrini, R., Davidson, L., Bhan, A.K and F.W. Alt. (1998) Wiskott-Aldrich Syndrome Protein Deficient Mice Reveal Role for WASP in T but not B cell activation. Immunity 9:81-91.
- Snapper SB, Rosen FS. The Wiskott-Aldrich syndrome protein (WASP): roles in signaling and cytoskeletal organization. Ann Rev Immunol 1999;17:905-929.
- Fruman, D., Snapper, S.B., Yballe, C.M., Davidson, L., Yu, J.Y., Alt, F.W., and L. C. Cantley. (1999) Impaired B Cell Development and Proliferation in Absence of Phosphoinositide 3-Kinase p85a. Science 283: 393-397.
- Bauch A, Alt FW, Crabtree G, Snapper SB. (2000) The cytoskeleton in lymphocyte signaling. Advances in Immunol;75:89-114.
- Krawczyk, C, Bachmaier, K, Sasaki, T, Jones, RG, Snapper, SB, Bouchard, D, Kozieradski, I, Ohashi, PS, Alt, FW, Peninger, JM (2000). Cbl-b is a negative Regulator of receptor Clustering and Raft Aggregation in T Cells. Immunity 13:463-473.
- Snapper, S.B., Takeshima, F., Anton, I., Liu, C.H., Thomas, S., Nguyen, D., Dudley, D., Fraser, H., Purich, D., Klein, C., Bronson, R., Mulligan, R., Southwick, F., Geha, R., Goldberg, M., Rosen, F.S., Hartwig, J. and Alt, F.W. (2001) N-WASP-Deficiency Reveals Distinct Pathways for Cell Surface Projections and Microbial Actin-Based Motility. Nature Cell Biology 3:897-904.
- Alrutz, M.A., Srivastava, A., Wong, K.W., D'sousa-Schorey, C., Tang, M., Ch'ng, L.E., Snapper, S.B. and Isberg, R.R.( 2001) Efficient Uptake of Yersinia Pseudotuberculosis via Intergrin Receptors Involves a Rac1-Apr 2/3 Pathway that Bypasses N-WASP Function. Molecular Microbiology 42(3): 689-703.
- Shibata, T., Takeshima, F., Chen, F., Alt , F.W. and Snapper, S.B. (2002) Cdc42 Facilitates Invasion but Not the Actin-Based Motility of Shigella. Current Biology 12: 341-34.
