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Browse news and press releases from the Division of Gastroenterology.
Wednesday, July 8, 2015 Mass General
Monday, December 1, 2014 Mass General
Friday, July 25, 2014 Mass General
Tuesday, July 15, 2014 Mass General
Friday, June 13, 2014 Mass General
Friday, May 23, 2014 Mass General
Thursday, October 10, 2013 Mass General
Thursday, August 1, 2013 Research
Tuesday, July 16, 2013 Mass General
Monday, September 24, 2012 Mass General
Monday, July 16, 2012 Mass General
Wednesday, November 23, 2011 Mass General
Tuesday, July 19, 2011 Mass General
Friday, July 16, 2010 Mass General
Wednesday, March 31, 2010 Mass General
Tuesday, January 19, 2010 Mass General
Friday, January 8, 2010 Mass General
Thursday, January 7, 2010 Clinical
Monday, June 29, 2009 Mass General
Wednesday, May 23, 2007 Research
By surveying gene expression in over 53,000 cells from the small intestine, researchers have created a rich reference for understanding the biology of inflammatory bowel disease and food allergies, among other conditions.
Massachusetts General Hospital investigators have identified differences in gene transcription within key immune cells that may distinguish those individuals infected with the hepatitis C virus who develop chronic infection from those whose immune systems successfully clear the virus.
Researchers from Massachusetts General Hospital have discovered how the bacteria Shigella survives its journey from the mouth to the colon, taking advantage of substances that would kill many less persistent organisms.
Researchers from Massachusetts General Hospital and the Broad Institute of MIT and Harvard have found that analysis of a patient’s gut microbiome – the microbial population of the gastrointestinal tract – may predict the likelihood of successful treatment for inflammatory bowel disease with biologic drugs that target immune system activity.
Massachusetts General Hospital investigators report that an intestinal enzyme previously shown to keep bacterial toxins from passing from the gastrointestinal system into the bloodstream may be able to reduce or prevent the liver damage caused by excess alcohol consumption.
With the help of genetically engineered mice, scientists at the Massachusetts General Hospital are moving closer to establishing the role that increased intestinal permeability, sometimes called a "leaky gut," plays in chronic inflammatory conditions.
Massachusetts General Hospital researchers have found how a variant in an important epigenetic enzyme – previously associated with Crohn’s disease and other immune disorders – interferes with the action of the innate immune system, potentially upsetting the balance between the microbial population of the gastrointestinal tract and the immune response.
Researchers from Massachusetts General Hospital and the University of California, Riverside, have shown for the first time that RNA interference – an antiviral mechanism known to be used by plants and lower organisms – is active in the response of human cells to some important viruses.
A study led by investigators at Massachusetts General Hospital and other institutions has begun to elucidate how differences in the gut microbiome – the microbial population of the gastrointestinal tract – affect the immune response in healthy individuals.
The largest study to examine the effects of different sources of dietary protein found that a high intake of proteins from animal sources – particularly processed and unprocessed red meats – was associated with a higher mortality rate, while a high intake of protein from plant sources was associated with a lower risk of death
A comprehensive analysis of changes in the intestinal microbial population during the first three years of life has revealed some of the impacts of factors such as mode of birth – vaginal versus cesarean section – and antibiotic exposure, including the effects of multiple antibiotic treatments.
A study led by MGH investigator Ramnik Xavier, MD, PhD, has found evidence that supports the hypothesis that early-life exposure to pathogens is beneficial to the development of the immune system and identifies interactions between bacterial species that may explain the increase in autoimmune and related disorders seen in western societies.
An analysis of data from two major, long-term epidemiologic studies finds that the regular use of aspirin significantly reduces the overall risk of cancer, a reduction that primarily reflects a lower risk of colorectal cancer and other tumors of the gastrointestinal tract.
Using ultrasound waves, researchers from MIT and Massachusetts General Hospital have found a way to enable ultra-rapid delivery of drugs to the gastrointestinal tract. This approach could make it easier to deliver drugs to patients suffering from GI disorders such as inflammatory bowel disease, ulcerative colitis, and Crohn’s disease.
A new approach to delivering inflammatory bowel disease treatments using a gel-like material has the potential to offer a more comfortable therapy that is less likely to have unintended side effects.
Researchers at MIT’s Koch Institute for Integrative Cancer Research and MGH have created a polymer gel that overcomes the risk of intestinal obstruction associated with medical devices designed to reside in the stomach.
New findings about the mechanisms involved – or not involved – in the effects of the most common form of bariatric surgery suggest that combining surgery with a specific type of medication could augment the benefits of the procedure.
A new study suggests that massive underreporting may occur within the system set up by the U.S. Centers for Disease Control and Prevention to estimate the incidence of acute hepatitis C virus infection.
This week, MIT and Massachusetts General Hospital (MGH) announce the launch of the Center for Microbiome Informatics and Therapeutics, a new interdisciplinary center dedicated to advancing the understanding of the microbiome’s role in human biology and harnessing this knowledge to develop treatments for related illnesses.
An study led by investigators at the MGHfC Center for Celiac Research and Treatment finds that neither breastfeeding nor delaying the introduction of gluten-containing foods prevents or delays the development of celiac disease in at-risk children.
A multi-institutional study led by investigators from MGH and the Broad Institute has identified how the intestinal microbial population of newly diagnosed Crohn's disease patients differs from that of individuals free of inflammatory bowel disease.
An MGH-led research team has identified an immune cell protein that is critical to setting off the body's initial response against viral infection. The report describes finding that a protein called GEF-H1 is essential to the ability of macrophages – major contributors to the innate immune system – to respond to viral infections like influenza.
A new study finds that colonoscopy appears to reduce the risk of developing or dying from colorectal cancer more powerfully than does sigmoidoscopy, a similar procedure that examines only a portion of the colon. The investigation also identifies molecular features that may help explain tumors that are diagnosed despite an individual's having recently undergone colonoscopy.
The FDA has released its definition of "gluten free" to be used by food manufacturers. The long-awaited regulations stem from research conducted by the Center for Celiac Research.
Chemicals secreted by "good" bacteria that typically live in the intestines of babies could reduce the frequency and severity of a common and often-lethal disease of premature infants.
A type of immune cell found in the small intestine plays a previously unsuspected role in monitoring antigens circulating in the bloodstream. Disruption of the newly discovered regulatory system may lead to the development of autoimmune disorders, inflammatory bowel disease or food allergies.
Aspirin use appears to reduce the risk of Barrett's esophagus, the largest known risk factor for esophageal cancer.
A genetic finding could help explain why influenza becomes a life-threating disease to some people while it has only mild effects in others.
The reduced risk of colorectal cancer associated with taking aspirin or other nonsteroidal anti-inflammatory drugs may be limited to individuals already at risk because of elevations in a specific inflammatory factor in the blood.
An international consortium has made significant inroads into uncovering the genetic basis of obesity by identifying 18 new gene sites associated with overall obesity and 13 that affect fat distribution. The studies include data from nearly a quarter of a million participants, the largest genetic investigation of human traits to date.
Researchers have identified a small family of flu-fighting proteins that somehow increases natural resistance to viral infection. The proteins block most virus particles from infecting the cell at the earliest stage in the virus lifecycle.
Regular use of aspirin after colorectal cancer diagnosis may reduce the risk of cancer death, report investigators from Massachusetts General Hospital, Dana-Farber Cancer Institute and Brigham and Women’s Hospital.
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