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Ongoing clinical trials for Barrett's esophagus: Actively recruiting


Condition:

Barrett’s Esophagus, esophageal cancer

Study title:

Discrimination of Barrett’s Metaplasia from Dysplasia with Pathfinder Topographic Genotyping

Description of study:

The aim of the study is to develop a utility to discriminate Barrett’s metaplasia from dysplasia or cancer using Pathfinder topographic genotyping

Basic eligibility criteria:

Patients who underwent biopsy and have a diagnosis of Barrett’s esophagus

Principal Investigator:

William Brugge, MD

Contact:

Ebubekir Daglilar, MD, CRC; 617-724-0462


Condition:

Barrett’s esophagus, esophageal cancer

Study title:

Barrett’s Esophagus Patient Registry (BPR)

Description of study:

The goal of the Barrett’s Esophagus Patient Registry is to help develop more effective targeted screening strategies and treatment options for Barrett’s esophagus and esophageal adenocarcinoma (EAC). We plan to do this by identifying genetic determinants and biomarkers that predict progression of BE to EAC as well as the response to BE therapy.

Basic eligibility criteria:

Patients 18 and older who have been diagnosed with Barrett’s esophagus or esophageal adenocarcinoma based upon standard endoscopic and histologic criteria.

Principal Investigator:

Chin Hur, MD, MPH

Contact:

Katherine Perzan, CCRC; 617-726-1431


Condition:

Barrett's esophagus

Study title:

Randomized Double Blind Placebo Controlled Phase II Trial of Barrett's Esophagus Chemoprevention with Metformin

Description of study:

The goal of this study is to find out if metformin, a drug most commonly used to treat type 2 diabetes, can prevent the progression of Barrett’s esophagus to esophageal adenocarcinoma. Metformin has been shown to have potential as a cancer prevention drug in other cancers such as breast and prostate.

Basic eligibility criteria:

Patients 18 and older who have a histologically confirmed diagnosis of Barrett’s esophagus at least 2 cm in length with either no dysplasia or low-grade dysplasia and who have been taking a daily proton pump inhibitor for at least 4 weeks. Patients with a history of high-grade dysplasia or esophageal cancer are not eligible. Patients who have had any kind of ablation or local therapies are also not eligible.

Principal Investigator:

Chin Hur, MD, MPH

Contact:

Katherine Perzan, CCRC; 617-726-1431