Neuroenteric Research Laboratory - Dr. Braden Kuo

The laboratory is focused upon clinical and translational research in GI Motility and Visceral Pain Syndromes such as GERD, gastroparesis, constipation and irritable bowel syndrome.

The research has several components including research into gut motility physiology in health and disease, understanding the brain circuitry of gut sensations, and clinical trials.

Creation of a Database of Patients with Cyclic Vomiting Syndrome to help determine the Effectiveness of Marinol on Nausea in this Patient Population

Clinical Outcomes of Patients with Upper GI Symptoms Evaluated by Gastric Emptying Scan

Endoscopically Guided Esophageal Manometry with Minimal Sedation

Non-Invasive Characterization of Gastric Motility Using MRI

Collection of Blood Samples for the Discovery of Biomarkers Associated With Irritable Bowel Syndrome

A pilot study on the efficacy of a 10-week mind body intervention on quality of life and inflammatory disease markers in patients with Irritable Bowel Syndrome (IBS) and Irritable Bowel Disease (IBD).

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel Group, Dose-Ranging Clinical Study to Evaluate the Efficacy and Safety of Metoclopramide Nasal Spray Solution in Diabetic Subjects w/ Gastroparesis

Psychometric Evaluation of the Gastroparesis Cardinal Symptom Index Daily Diary (GCSI-D) in Patients with Gastroparesis

Detection of the Influences of Proton Pump Inhibitors on Gastric Residence Time, by Using the Smartpill Wireless Capsule

Endoscopic Mucosal Resection for the Diagnosis of a-Ganglionosis: A Controlled Prospective Trial (EDGE Trial)

Assessment of Whole Gut Transit Time Using the SmartPill Capsule: A Multicenter Study

Brain Response to Motion Sickness with Acupuncture Prophylaxis

Defining Central Circuits of Visceral Pain

Clinical Research Fellow in GI Motility

Selected Publications

1. Kuo B, Castell DO. The effect of nasogastric intubation on gastroesophageal reflux: a comparison of different tube sizes. Am J Gastroenterol. 1995;90(10):1804-7.

  1. Kuo B, Castell DO. Optimal dosing of omeprazole 40 mg daily: effects on gastric and esophageal pH and serum gastrin in healthy controls. Am J Gastroenterol. 1996;91(8):1532-8.
  2. Hatlebakk JG, Katz PO, Kuo B, Castell DO. Nocturnal gastric acidity and acid breakthrough on different regimens of omeprazole 40 mg daily. Alim Pharm Thera. 1998;12(12):1235-40.
  3. Kuo B, Camilleri M, Burton D, Viramontes B Mckinzie S, Thomforde G, O’Connor MK, Brinkman BH. Effects of 5-HT3 Antagonism on Postprandial Gastric Volume and Symptoms in Humans. Alim Pharm Thera. 2002;16(2):225-235. PMID: 11860405
  4. Ferris TG, Shea T, Jacobson BC, Bainbridge J, Dudley J, Mahlis EM, Kuo B, Wang TC, Lee TH. A Population-Based Intervention to Improve Management of Patients on Chronic Acid Suppression: A Group-Randomized Trial. J Clin Outcomes Manage. 2004;12(1):35-43.
  5. Cole JA, Yeaw JM, Cutone JA, Kuo B, Huang Z, Earnest DL, Walker AM. The incidence of abdominal and pelvic surgery among patients with irritable bowel syndrome. Dig Dis Sci. 2005;50(12):2268-75, 2005.
  6. Kuo B, McCallum RW, Koch KL, Sitrin MD, Wo JM, Chey WD, Hasler WL, Lackner JM, Katz LA, Semler JR, Wilding GE, Parkman HP. Comparison of gastric emptying of a nondigestible capsule to a radio-labelled meal in healthy and gastroparetic subjects. Alim Pharmac Therap. 2008;27(2):186-96. PMID: 17973643
  7. Hasler WL, Coleski R, Chey WD, Koch KL, McCallum RW, Wo JM, Kuo B, Sitrin MD, Katz LA, Hwang J, Semler JR, Parkman HP. Differences in Intragastric pH in Diabetic Versus Idiopathic Gastroparesis: Relation to Degree of Gastric Retention. Am J Physiol Gastrointest Liver Physiol 2008; 294:G1384-91. PMID: 18403619
  8. Gaman A, Kuo B. Neuromodulatory Processes of the Brain–Gut Axis. Neuromodulation 2008; 11(4):249-259. PMID: 19844605
  9. Rao SS, Kuo B, McCallum RW, Chey WD, DiBaise JK, Hasler WL, Koch KL, Lackner JM, Miller C, Saad R, Semler JR, Sitrin MD, Wilding GE, Parkman HP. Investigation of wireless manometry capsule for colonic and whole gut transit: a comparative study with radioopaque markers in health and constipation. Clin Gastroenterol Hepatol 2009; 7(5):537-44. PMID:19418602
  10. Sarosiek I, Selover KH, Katz LA, Semler JR, Wilding GE, Lackner JM, Sitrin MD, Kuo B, Chey WD, Hasler WL, Koch KL, Parkman HP, Sarosiek J, McCallum RW. Clinical trial: assessment of regional gut transit times in healthy controls and patients with gastroparesis using wireless motility technology. Aliment Pharmacol Ther. 2009 Oct 8. PMID: 19814743
  11. Hasler WL, Saad RJ, Rao SS, Wilding GE, Parkman HP, Koch KL, McCallum RW, Kuo B, Sarosiek I, Sitrin MD, Semler JR, Chey WD. Heightened colon motor activity measured by a wireless capsule in patients with constipation: relation to colon transit and IBS. Am J Physiol Gastrointest Liver Physiol. 2009;297(6):G1107-14. PMID: 19808653.
  12. Kwong KK, Kloetzer L, Wong KK, Ren JQ, Kuo B, Jiang Y, Chen YI, Chan ST, Young GS, Wong ST. Bioluminescence imaging of heme oxygenase-1 upregulation in the Gua Sha procedure. J Vis Exp. 2009 Aug 28;(30). pii: 1385. doi: 10.3791/1385. PMID: 19718012
  13. Revicki DA, Camilleri M, Kuo B, Norton NJ, Murray L, Palsgrove A, Parkman HP. Development and content validity of a gastroparesis cardinal symptom index daily diary. Aliment Pharmacol Ther. 2009 Sep 15;30(6):670-80. Epub 2009 Jun 25. PMID: 19558608
  14. Lacount L, Napadow V, Kuo B, Park K, Kim J, Brown E, Barbieri R. Dynamic Cardiovagal Response to Motion Sickness: A Point-Process Heart Rate Variability Study. Comput Cardiol. 2009 ;36:49-52. PMID: 20445767
  15. Kloetzer L, Chey WD, McCallum RW, Koch KL, Wo JM, Sitrin M, Katz LA, Lackner JM, Parkman HP, Wilding GE, Semler JR, Hasler WL, Kuo B. Motility of the antroduodenum in healthy and gastroparetics characterized by wireless motility capsule. Neurogastroenterol Motil. 2010;22(5):527-33. PMID: 20122128.
  16. Sarosiek I, Selover KH, Katz LA, Semler JR, Wilding GE, Lackner JM, Sitrin MD, Kuo B, Chey WD, Hasler WL, Koch KL, Parkman HP, Sarosiek J, McCallum RW. Clinical trial: assessment of regional gut transit times in healthy controls and patients with gastroparesis using wireless motility technology. Aliment Pharmacol Ther. 2010;31(2):313-22. PMID: 19814743.
  17. Saad RJ, Rao SS, Koch KL, Kuo B, Parkman HP, McCallum RW, Sitrin MD, Wilding GE, Semler JR, Chey WD. Do stool form and frequency correlate with whole-gut and colonic transit? Results from a multicenter study in constipated individuals and healthy controls. Am J Gastroenterol. 2010;105(2):403-11. PMID: 19888202
  18. Parkman HP, Camilleri M, Farrugia G, McCallum RW, Bharucha AE, Mayer EA, Tack JF, Spiller R, Horowitz M, Vinik AI, Galligan JJ, Pasricha PJ, Kuo B, Szarka LA, Marciani L, Jones K, Parrish CR, Sandroni P, Abell T, Ordog T, Hasler W, Koch KL, Sanders K, Norton NJ, Hamilton F. Gastroparesis and functional dyspepsia: excerpts from the AGA/ANMS meeting. Neurogastroenterol Motil. 2010 ;22(2):113-33. PMID: 20003077

 

Reviews/Chapters/Editorials

 

  1. Kuo B. The Esophagogastric Junction. Gastroenterology. 1999;116 (1):224.
  2. Kuo B, Friedman LS. Bowel Sounds. In: Gastrointestinal Diseases, Feldman M, Friedman LS, eds., Saunders, 7th edition, Philadelphia, 2002;82-83.
  3. Kuo B. Chronic Abdominal Pain. In: Gastrointestinal Diseases, Feldman M, Friedman LS, eds., Saunders, 8th edition, Philadelphia, 2006.
  4. Kuo B, Urma D. Esophagus - Anatomy and Development. In: Goyal and Shaker’s GI Motility Online; Edited by Goyal, R K and Shaker, R. Nature Publishing Group: New York, 2006. doi:10.1038/gimo 6
  5. Podovei M, Kuo B. Irritable Bowel Syndrome. Southern Medical Journal, South Med J 2006;99(11):1235-42.
  6. Gaman A, Kuo B. Medical procedure costs and surgical rates in patients with Irritable Bowel Syndrome. International Foundation for Functional Gastrointestinal Diseases Journal. 2007;16(2):3-6.
  7. Gaman A, Kuo B. Neuromodulatory Processes of the Brain–Gut Axis. Neuromodulation 2008; 11(4):249-259.
  8. Gaman A, Kuo B. Embryology. In: Esophageal Tumors: Principles and Practice, Blair Jobe B, Thomas C, Hunter J, eds. Demos Medical Publishing 2009.
  9. Gaman A, Kuo B. Anatomy. In: Esophageal Tumors: Principles and Practice, Blair Jobe B, Thomas C, Hunter J, eds. Demos Medical Publishing 2009.
  10. Gaman A, Bucur C, Kuo B. Therapeutic advances in functional GI diseases: Irritable Bowel Syndrome. Therapeutic Advances in Gastroenterology. 2009: 2(3) 169–181.
  11. Kloetzner L, Kuo B. Ambulatory Capsule for Transit and Pressure. In Gastrointestinal Motility Testing: Laboratory and Office Handbook, Parkman HP, Rao SC, McCallum RW eds. Cambridge University Press 2010.
  12. Aziz Q, Coen S, Kern M, Labus J, Lane R, Kuo B, Naliboff B, Tracey I, Mayer E. Brain imaging approaches to the study of functional GI disorders: a Rome working team report. Neurogastroenterol Motil. 2009 Jun;21(6):579-96.
  13. Parkman H, Camilleri M, Farrugia G, Mccallum R, Bharucha A, Mayer E, Tack J, Spiller R, Horowitz M, Galligan J, Pasricha P, Kuo B, Szarka L. Gastroparesis and Functional Dyspepsia: Excerpts from the AGA/ANMS Meeting. . Neurogastroenterol Motil. 2010 electronically accepted.
  14. Kuo B. Recent Advances in Gastric Function Testing. Oakstone Publishing.
  15. Lee A, Kuo B. Recent Advances in Gastric Function Testing. US Gastroenterology and Hepatology Reviews. Accepted. 2010.
  16. Brun M, Kuo B. Promotility Drugs: Not all Uniform. Indian Journal of Gastroenteorology. Editorial accepted 2010.
  17. Brun M, Kuo B. Functional Dyspepsia. Therapeutic Advances in Gastroenterology. 2010 accepted.