Clinicians at the Mass General CIST Center diagnose, treat and monitor patients with pancreatic cystic lesions.

Pancreatic cysts  

Featured Publications

The physicians at the Cyst Imaging Surveillance and Treatment (CIST) Center at Massachusetts General Hospital are active researchers. Members of the CIST team actively publish clinical and translational papers describing their advancements in diagnosis and treatment of pancreatic cysts.

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Blake 4
55 Fruit Street
Boston, MA 02114
617-724-0578

Brenna W. Casey, MD

  • Lee LS, Saltzman JR, Bounds BC, Poneros JM, Brugge WR, Thompson CC. EUS-guided fine needle aspiration of pancreatic cysts: a retrospective analysis of complications and their predictors. Clin Gastroenterol Hepatol. 2005;3(3):231-6. PMID: 15765442. PubMed
  • Gan SI, Thompson CC, Lauwers GY, Bounds BC, Brugge WR. Ethanol lavage of pancreatic cystic lesions: initial pilot study. Gastrointest Endosc. 2005;61(6):746-52. PMID: 15855986. PubMed
  • Pitman MB, Michaels PJ, Deshpande V, Brugge WR, Bounds BC. Cytological and cyst fluid analysis of small (< or =3 cm) branch duct intraductal papillary mucinous neoplasms adds value to patient management decisions. Pancreatology. 2008;8(3):277-84. PMID: 18497541. PubMed

William R. Brugge, MD

  • Yoon WJ, Brugge WR. Pancreatic cystic neoplasms: diagnosis and management. Gastroenterol Clin North Am. 2012;41(1):103-18. PMID: 22341252. PubMed
  • Iftimia N, Yoon WJ, Brugge WR. Cystic lesions of the pancreas: more reliable differentiation with in situ high-resolution optical imaging? Expert Rev Gastroenterol Hepatol. 2012;6(2):125-7. PMID: 22375515. PubMed
  • Brugge WR, Wallace MB. FISHing: new methods to improve the diagnostic sensitivity of fine needle aspiration cytology. Gastroenterology. 2012;142(5):1055-7. PMID: 22446080. PubMed

Carlos Fernandez-del Castillo, MD

  • Alexander BM, Fernandez-Del Castillo C, Ryan DP, Kachnic LA, Hezel AF, Niemierko A, Willett CG, Kozak KR, Blaszkowsky LS, Clark JW, Warshaw AL, Hong TS. Intraductal papillary mucinous adenocarcinoma of the pancreas: clinical outcomes, prognostic factors, and the role of adjuvant therapy. Gastrointest Cancer Res. 2011;4(4):116-21. PMID: 22368734. PubMed
  • Arvold ND, Ryan DP, Niemierko A, Blaszkowsky LS, Kwak EL, Wo JY, Allen JN, Clark JW, Wadlow RC, Zhu AX, Fernandez-Del Castillo C, Hong TS. Long-term outcomes of neoadjuvant chemotherapy before chemoradiation for locally advanced pancreatic cancer. Cancer. 2012;118(12):3026-35. PMID: 22020923. PubMed
  • Conrad C, Fernandez-Del Castillo C. Preoperative evaluation and management of the pancreatic head mass. J Surg Oncol. 2012. PMID: 22674403. PubMed

Cristina Ferrone, MD

  • Haynes AB, Deshpande V, Ingkakul T, Vagefi PA, Szymonifka J, Thayer SP, Ferrone CR, Wargo JA, Warshaw AL, Fernandez-del Castillo C. Implications of incidentally discovered, nonfunctioning pancreatic endocrine tumors: short-term and long-term patient outcomes. Arch Surg. 2011;146(5):534-8. PMID: 21576607. PubMed
  • Cecchini S, Correa-Gallego C, Desphande V, Ligorio M, Dursun A, Wargo J, Fernandez-del Castillo C, Warshaw AL, Ferrone CR. Superior prognostic importance of perineural invasion vs. lymph node involvement after curative resection of duodenal adenocarcinoma. J Gastrointest Surg. 2012;16(1):113-20; discussion 120. PMID: 22005894. PubMed
  • Kelly PJ, Shinagare S, Sainani N, Hong X, Ferrone C, Yilmaz O, Fernandez-del Castillo C, Lauwers GY, Deshpande V. Cystic papillary pattern in pancreatic ductal adenocarcinoma: a heretofore undescribed morphologic pattern that mimics intraductal papillary mucinous carcinoma. Am J Surg Pathol. 2012;36(5):696-701. PMID: 22367300. PubMed

David Forcione, MD

  • Catalano OA, Sahani DV, Forcione DG, Czermak B, Liu CH, Soricelli A, Arellano RS, Muller PR, Hahn PF. Biliary infections: spectrum of imaging findings and management. Radiographics. 2009;29(7):2059-80. PMID: 19926762. PubMed
  • Forcione DG, Brugge WR. New kid on the block? Autoimmune pancreatitis. Best Pract Res Clin Gastroenterol. 2010;24(4):361-78. PMID: 20833341. PubMed
  • Telford JJ, Carr-Locke DL, Baron TH, Poneros JM, Bounds BC, Kelsey PB, Schapiro RH, Huang CS, Lichtenstein DR, Jacobson BC, Saltzman JR, Thompson CC, Forcione DG, Gostout CJ, Brugge WR. A randomized trial comparing uncovered and partially covered self-expandable metal stents in the palliation of distal malignant biliary obstruction. Gastrointest Endosc. 2010;72(5):907-14. PMID: 21034891. PubMed

Keith Lillemoe, MD

  • Waters JA, Schnelldorfer T, Aguilar-Saavedra JR, Chen JH, Yiannoutsos CT, Lillemoe KD, Farnell MB, Sarr MG, Schmidt CM. Survival after resection for invasive intraductal papillary mucinous neoplasm and for pancreatic adenocarcinoma: a multi-institutional comparison according to American Joint Committee on Cancer Stage. J Am Coll Surg. 2011;213(2):275-83. PMID: 21601488. PubMed
  • Beane JD, House MG, Cote GA, DeWitt JM, Al-Haddad M, LeBlanc JK, McHenry L, Sherman S, Schmidt CM, Zyromski NJ, Nakeeb A, Pitt HA, Lillemoe KD. Outcomes after preoperative endoscopic ultrasonography and biopsy in patients undergoing distal pancreatectomy. Surgery. 2011;150(4):844-53. PMID: 22000199. PubMed
  • Cauley CE, Waters JA, Dumas RP, Meyer JE, Al-Haddad MA, DeWitt JM, Lillemoe KD, Schmidt CM. Outcomes of primary surveillance for intraductal papillary mucinous neoplasm. J Gastrointest Surg. 2012;16(2):258-67; discussion 266. PMID: 22089952. PubMed

Vikram Deshpande, MD

  • Ferrone CR, Pieretti-Vanmarcke R, Bloom JP, Zheng H, Szymonifka J, Wargo J, Thayer SP, Lauwers GY, Deshpande V, Mino-Kenudson M, Castillo CF, Lillemoe KD, Warshaw AL. Pancreatic ductal adenocarcinoma: Long-term survival does not equal cure. Surgery. 2012. PMID: 22763261. PubMed
  • Arvold ND, Willett CG, Fernandez-Del Castillo C, Ryan DP, Ferrone CR, Clark JW, Blaszkowsky LS, Deshpande V, Niemierko A, Allen JN, Kwak EL, Wadlow RC, Zhu AX, Warshaw AL, Hong TS. Pancreatic neuroendocrine tumors with involved surgical margins: prognostic factors and the role of adjuvant radiotherapy. Int J Radiat Oncol Biol Phys. 2012;83(3):e337-43. PMID: 22414286. PubMed
  • Kelly PJ, Shinagare S, Sainani N, Hong X, Ferrone C, Yilmaz O, Fernandez-del Castillo C, Lauwers GY, Deshpande V. Cystic papillary pattern in pancreatic ductal adenocarcinoma: a heretofore undescribed morphologic pattern that mimics intraductal papillary mucinous carcinoma. Am J Surg Pathol. 2012;36(5):696-701. PMID: 22367300. PubMed

Mari Mino-Kenudson, MD

  • Ono J, Yaeger KA, Genevay M, Mino-Kenudson M, Brugge WR, Pitman MB. Cytological analysis of small branch-duct intraductal papillary mucinous neoplasms provides a more accurate risk assessment of malignancy than symptoms. Cytojournal. 2011;8:21. PMID: 22145009. PubMed
  • Genevay M, Mino-Kenudson M, Yaeger K, Konstantinidis IT, Ferrone CR, Thayer S, Castillo CF, Sahani D, Bounds B, Forcione D, Brugge WR, Pitman MB. Cytology adds value to imaging studies for risk assessment of malignancy in pancreatic mucinous cysts. Ann Surg. 2011;254(6):977-83. PMID: 22041510. PubMed
  • Mino-Kenudson M, Fernandez-del Castillo C, Baba Y, Valsangkar NP, Liss AS, Hsu M, Correa-Gallego C, Ingkakul T, Perez Johnston R, Turner BG, Androutsopoulos V, Deshpande V, McGrath D, Sahani DV, Brugge WR, Ogino S, Pitman MB, Warshaw AL, Thayer SP. Prognosis of invasive intraductal papillary mucinous neoplasm depends on histological and precursor epithelial subtypes. Gut. 2011;60(12):1712-20. PMID: 21508421. PubMed

Martha Pitman, MD

  • Ono J, Yaeger KA, Genevay M, Mino-Kenudson M, Brugge WR, Pitman MB. Cytological analysis of small branch-duct intraductal papillary mucinous neoplasms provides a more accurate risk assessment of malignancy than symptoms. Cytojournal. 2011;8:21. PMID: 22145009. PubMed
  • Genevay M, Mino-Kenudson M, Yaeger K, Konstantinidis IT, Ferrone CR, Thayer S, Castillo CF, Sahani D, Bounds B, Forcione D, Brugge WR, Pitman MB. Cytology adds value to imaging studies for risk assessment of malignancy in pancreatic mucinous cysts. Ann Surg. 2011;254(6):977-83. PMID: 22041510. PubMed
  • Tanaka M, Fernandez-Del Castillo C, Adsay V, Chari S, Falconi M, Jang JY, Kimura W, Levy P, Pitman MB, Schmidt CM, Shimizu M, Wolfgang CL, Yamaguchi K, Yamao K. International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas. Pancreatology. 2012;12(3):183-97. PMID: 22687371. PubMed

Dushyant Sahani, MD

  • Sahani DV, Sainani NI, Blake MA, Crippa S, Mino-Kenudson M, del-Castillo CF. Prospective evaluation of reader performance on MDCT in characterization of cystic pancreatic lesions and prediction of cyst biologic aggressiveness. AJR Am J Roentgenol. 2011;197(1):W53-61. PMID: 21700995. PubMed
  • Genevay M, Mino-Kenudson M, Yaeger K, Konstantinidis IT, Ferrone CR, Thayer S, Castillo CF, Sahani D, Bounds B, Forcione D, Brugge WR, Pitman MB. Cytology adds value to imaging studies for risk assessment of malignancy in pancreatic mucinous cysts. Ann Surg. 2011;254(6):977-83. PMID: 22041510. PubMed
  • Perez-Johnston R, Sainani NI, Sahani DV. Imaging of chronic pancreatitis (including groove and autoimmune pancreatitis). Radiol Clin North Am. 2012;50(3):447-66. PMID: 22560691. PubMed

Sarah Thayer, MD, PhD

  • Mino-Kenudson M, Fernandez-del Castillo C, Baba Y, Valsangkar NP, Liss AS, Hsu M, Correa-Gallego C, Ingkakul T, Perez Johnston R, Turner BG, Androutsopoulos V, Deshpande V, McGrath D, Sahani DV, Brugge WR, Ogino S, Pitman MB, Warshaw AL, Thayer SP. Prognosis of invasive intraductal papillary mucinous neoplasm depends on histological and precursor epithelial subtypes. Gut. 2011;60(12):1712-20. PMID: 21508421. PubMed
  • Haynes AB, Deshpande V, Ingkakul T, Vagefi PA, Szymonifka J, Thayer SP, Ferrone CR, Wargo JA, Warshaw AL, Fernandez-del Castillo C. Implications of incidentally discovered, nonfunctioning pancreatic endocrine tumors: short-term and long-term patient outcomes. Arch Surg. 2011;146(5):534-8. PMID: 21576607. PubMed
  • Valsangkar NP, Morales-Oyarvide V, Thayer SP, Ferrone CR, Wargo JA, Warshaw AL, Castillo CF. 851 resected cystic tumors of the pancreas: A 33-year experience at the Massachusetts General Hospital. Surgery. 2012. PMID: 22770958. PubMed