The Gut-2-Health Program at Massachusetts General Hospital brings together a team of experts to diagnose, treat and conduct collaborative research with patients that have inherited or acquired diseases with an allergic and inflammatory component, including eosinophilic esophagitis and microscopic colitis.
A Collaborative Approach to Delivering Patient Care
At the Gut-2-Health clinic, we are dedicated to harnessing a strong doctor-patient partnership during diagnosis and treatment of allergic-inflammatory disorders of the GI tract. At the individual patient level, a personal care team headed by one of our GI specialists coordinates each patient's care. The specialist meets regularly with the other team members to review individual patient cases and to update treatment plans. The team works with both the patient and the referring physician to coordinate a care plan designed to produce the best possible outcome. In addition to GI doctors, the team includes:
- GI Radiologists
- GI Pathologists
Consultation and Dialogue
As part of our patient-centered focus, we are dedicated to having patients be active partners in their care through consultation and dialogue with physicians. Using information from patients, our doctors are exploring how diet, lifestyle and environment may impact GI health so that they can give our patients the most insightful information and advice to help manage their disease. We regularly publish our findings on these topics; some relevant articles are featured below.
- Higher predicted vitamin D status is associated with reduced risk of Crohn's disease.
Ananthakrishnan AN, Khalili H, Higuchi LM, Bao Y, Korzenik JR, Giovannucci EL, Richter JM, Fuchs CS, Chan AT.
Gastroenterology. 2012 Mar;142(3):482-9.
- Hormone therapy increases risk of ulcerative colitis but not Crohn's disease.
Khalili H, Higuchi LM, Ananthakrishnan AN, Manson JE, Feskanich D, Richter JM, Fuchs CS, Chan AT.
Gastroenterology. 2012 Nov;143(5):1199-206.
To better serve patients, we are performing cutting-edge research in a variety of fields such as advanced imaging and the study of gut bacteria in the diagnosis and treatment of GI-related diseases.
- Tethered capsule endomicroscopy enables less invasive imaging of gastrointestinal tract microstructure.
Gora MJ, Sauk JS, Carruth RW, Gallagher KA, Suter MJ, Nishioka NS, Kava LE, Rosenberg M, Bouma BE, Tearney GJ.
Nat Med. 2013 Feb;19(2):238-40. Read about this article in the Harvard Gazette.
- How to value technological innovation: a proposal for determining relative clinical value.
Ladabaum U, Brill JV, Sonnenberg A, Shaheen NJ, Wilcox CM, Park WG, Hur C, Pasrich PJ.
Gastroenterology. 2013 Jan;144(1):5-8
- Conserved shifts in the gut microbiota due to gastric bypass reduce host weight and adiposity.
Liou AP, Paziuk M, Luevano JM Jr, Machineni S, Turnbaugh PJ, Kaplan LM.
Sci Transl Med. 2013 Mar 27;5(178). Read coverage of this study in the New York Times.
- Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment.
Morgan XC, Tickle TL, Sokol H, Gevers D, Devaney KL, Ward DV, Reyes JA, Shah SA, LeLeiko N, Snapper SB, Bousvaros A, Korzenik J, Sands BE, Xavier RJ, Huttenhower C
Genome Biol. 2012 Apr 16;13(9):R79. doi: 10.1186/gb-2012-13-9-r79.
One Call Coordinates Care
We provide patients and referring physicians with an experienced access coordinator, a clinician who is available to assess patients’ needs and coordinate appointments. Contact the Gut-2-Health Program access coordinator.
Our specialists are recognized for their expertise in diagnosing and treating patients with complex GI diseases that have an allergic-inflammatory component such as eosinophilic esophagitis and microscopic colitis. We also specialize in the diagnosis and treatment of rare genetic syndromes such as familial Mediterranean fever (FMF) that lead to inflammation of the GI system.
Our doctors participate in community events throughout the year to help educate the public on how diet, lifestyle and environment can affect GI health.
- Event: Gluten, Dairy, and Nuts, Oh My! Why Are Food Allergies on the Rise?
Panel discussion of medical experts and local chefs that will explore what we are learning about our increasing sensitivity to food.
Fri, Apr 19, 2013 6:00p.m. - 9:00p.m.
Broad Institute, 7 Cambridge Center, Kendall Square, Cambridge, MA 02139
Eosinophilic esophagitis (EoE) is a disorder of the esophagus that can affect patients of any age, and typically presents with difficulty swallowing, food getting stuck and sometimes chest pain or an abnormal sensation in the chest and upper abdomen. The eosinophil is a specialized type of immune cell that plays an important role in many allergic disorders, and EoE results from an abnormal accumulation of eosinophils in the lining of the esophagus.
Microscopic colitis is a disorder characterized by intermittent to chronic watery non-bloody diarrhea with a normal-appearing colon on colonoscopy or CT scan. However, upon biopsy of the colon, microscopic evidence of inflammation can be observed; hence the term microscopic colitis. Pathologically, this inflammation is characterized by either inflammatory immune cells called lymphocytes or the deposition of a type of material along the lining of the colon called collagen, giving rising the two subtypes of microscopic colitis called lymphocytic colitis and collagenous colitis.
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