Recent Publications: From the MGH Endocrine Surgery Unit


Lubitz CC, Stephen AE, Hodin RA Pandharipande P. Pre-operative localization strategies for Primary Hyperparathyroidism: An economic analysis. Annals of Surgical Oncology. In press.

Prescott, JD, Sadow PM, Hodin RA, Le LP, Gaz RD, Randolph GW, Stephen AE, Parangi S, Daniels GH, Lubitz CC. BRAFV600E status adds incrementally to currect risk classification systems in predicting papillary thyroid carcinoma recurrence. In press.

Phitayakorn R, McHenry CR.  Perioperative Management of Adrenal Tumors.  J Surg Oncol. 2012 Apr 18. doi: 10.1002/jso.23129. [Epub ahead of print]

Nucera C, Lawler J, and Parangi, S. BRAFV600E and microenvironment in thyroid cancer: a functional link to drive cancer progression. Cancer Res. In press.

Dionigi G, Barczynski M, Chiang Fy, Dralle H, Duran M, Iacobone M, Lombardi CP, Mateazzi G, Mihai R, Randolph GW, Sitges-Serra A. Why Monitor the recurrent laryngeal nerve in thyroid surgery?  Journal of Endocrinological Investigation. In press.

Nehs MA, Nucera C, Nagarkatti SS, Sadow PM, Hodin RA, Parangi S. Late intervention with anti-BRAFV600E therapy induces tumor regression in an orthotopic mouse model of human anaplastic thyroid cancer. Endocrinology. 2012 Feb;153(2):985-94.

Nucera C, Nehs MA, Nagarkatti SS, Sadow PM, Mekel M, Fischer AH, Lin PS, Bollag GE, Lawler J, Hodin RA, and Parangi S. Targeting BRAFV600E with PLX4720 displays potent anti migratory and invasive activity in preclinical models of human thyroid cancer. Oncologist. 2011 Feb 25.

Yip DT, Hassan M, Pazaitou-Panayiotou K, Ruan DT, Gawande AA, Gaz RD, Moore FD, Jr., Hodin RA, Stephen AE, Sadow PM, Daniels GH, Randolph GW, Parangi S, Lubitz CC. Preoperative basal calcitonin level and not extent of surgery correlates with post-operative calcitonin levels in patients undergoing initial surgical management of medullary thyroid carcinoma. Surgery. 2011 Dec; 150(6): 1168-77.

Lubitz, CC, Nagarkatti, SS, Faquin, WC, Samir, AE, Hassan, MC, Barbesino, G, Ross, DS, Randolph, GW, Gaz, RD, Stephen, AE, Hodin, RA, Daniels, GH, Parangi, S. Diagnostic Yield of Non-Diagnostic Thyroid Nodules Is Not Altered by Timing of Repeat Biopsy. Thyroid. 2012 Jun; 22(6): 590-4.  

Randolph GW, Henning D and the International Neural Monitoring Study Group. Electrophysiologic Recurrent Laryngeal Nerve Monitoring During Thyroid and Parathyroid Surgery: International Standards Guideline Statement. Laryngoscope, 121:S1–S16, 2011.

Shin J, Grillo H, Mathisen D, Katlic M, Zurakowski D, Kamani D, Randolph GW. Surgical Management of Goiter: Part I Preoperative Assessment. Laryngoscope 121: 60-67, 2011.

Randolph GW,  Shin J, Grillo H, Mathisen D, Katlic M, Kamani D, Zurakowski D. Surgical Management of Goiter: Part  II Surgical Treatment and Results. Laryngoscope 121: 68-76, 2011.

Shin JJ, Rauch SD, Wasserman J, Coblens O, Randolph GW. Evidence-based medicine in otolaryngology, part 2: the current state of affairs. Otolaryngol Head Neck Surg 144(3) 331-337, 2011 Jan 31.

Goldfarb M, Perry Z, Hodin RA, Parangi S. Medical and surgical risks in thyroid surgery: Lessons from the NSQIP. Annals of Surgical Oncology 2011.

Lubitz, CC, Hunter, GJ, Hamberg, LM, Parangi, S, Ruan, D, Gawande, A, Gaz, RD, Randolph, GW Moore, FD Jr., Hodin, RA, Stephen, AE. Accuracy of 4D-CT in Poorly-Localized Patients with Primary Hyperparathyroidism. Surgery. 2010 Dec: 148 (6): 1129-1138.

Mekel M, Stephen AE, Gaz, RD, Randolph GW, Lubitz CC, Nehs MA, Parangi S, and Hodin RA. Surgical drains can be safely avoided in modified radical neck dissections for thyroid cancer. American Journal of Surgery, 2010 199(4):485-90

Lubitz CC,  Faquin WC, Yang J, Hodin RA,  Gaz RD , Parangi S,  Randolph G and Stephen AE. Clinical and Cytological Features Predicitve of Malignancy in Follicular Neoplasms. Thyroid. 2010 Jan; 20(1):25-31.

Nucera C, Porello, A, Antonello ZE, Mekel M Nehs MC,  Giordano TJ, Gerald D, Bejamin LE, Priolog C, Puxeddu E, Finn S, Jarzab B, Hodin RA, Pontercorvi A, Nose V, Lawler J, and Parangi, S. B-RafV600E and Thrombospondin-1 Promote Thyroid Cancer Progression. Proc Natl Acad Sci U S A. 2010 Jun 8; 107(23):10649-54.
Kato MA, Finley DJ, Lubitz CC, Zhu B, Moo TA, Loeven MR, Ricci JA, Zarnegar R, Katdare M, Fahey TJ 3rd. Selenium decreases thyroid cancer cell growth by increasing expression of GADD153 and GADD34. Nutr Cancer. 2010; 62(1):66-73.
Mekel M, Nucera C, Hodin RA, and Parangi S. Surgical Implications of BRAF V600E mutation in fine needle aspiration of thyroid nodules. Am J Surg. 2010 Jul; 200(1).

Nehs MC, Nagarkatti, S, Nucera C, Hodin RA, and Parangi, S. Thyroidectomy with neoadjuvant PLX4720 extends survival and decreases tumor burden in an orthotopic mouse model of anaplastic thyroid cancer. Surgery. 2010 Dec; 148(6):1154-62; discussion 1162.

Goldfarb M, Gondek S, Hodin RA, and Parangi S. Resident/Fellow assistance in the operating room for endocrine surgery in the era of fellowships. Surgery. 2010 Dec; 148(6):1065-71; discussion 1071-2.

Lubitz CC, Faquin WC, Gaz R, Parangi S, Randolph GW, Hodin RA, Stephen AE. Metastatic Melanoma to Thyroid: A Case Report and Institutional Review. World Journal of Endocrine Surgery 2010 May-Aug; 2 (2): 97-100.

Yip L, Kebebew E, Milas M, Carty SE, Fahey TJ, Parangi S, Zeiger MA, and Nikiforov YE. Summary statement:  Utility of molecular marker testing in thyroid cancer. Surgery Dec, 2010 148(6): 1313-5.

Nucera C, Lawler J, Hodin RA, and Parangi, S. The BRAFV600E mutation: what is it really orchestrating in thyroid cancer? Oncotarget, 2010 Dec;1(8):751-6.
Cabot RC, Harris NL, Shepard JA, Rosenberg ES, Cort AM, Peters CC, Misra M, Parangi S, Ross DS, Shailam R and  Sadow PM:  Case records of the Massachusetts General Hospital:  Case 38-2010: A 13 year old girl with an enlarging neck mass, NEJM CPC:  N Engl J Med. 2010 Dec 16;363(25):2445-54.
Phitayakorn R, McHenry CR.  Jaw Tumor: An Uncommon Manifestation of Primary Hyperparathyroidism.  World Journal of Endocrine Surgery.  2010 Fall Issue.

Pierce E, Randolph GW. Surgery of the Well Differentiated Thyroid Carcinoma:  The pendulum swings back in the central neck (Editorial) Endocrine Practice; 16 (5) 913-917, 2010.

Perrier N, Randolph GW, Inabnet W, Marple B, vanHeerden J, Kuppersmith R. Robotic Thyroidectomy A Framework for New Technology Assessment and Safe Implementation. Thyroid, 20 (12): 1327-1332, 2010.

Randolph GW. Papillary cancer nodal surgery and the advisability of prophylactic central neck dissection: Primum, non nocere. (Editorial). Surgery, 148(6):1108-1112, 2010.

Randolph GW. The importance of pre- and postoperative laryngeal examination for thyroid surgery. (Editorial) Thyroid 20(5):453-8, 2010.
Shin JJ, Randolph GW, Rauch SD. Evidence-based medicine in otolaryngology, part 1: the multiple faces of evidence-based medicine. Otolaryngol Head Neck Surg. 142(5):637-46, 2010.

Scott AR, Chong PS, Hartnick  CJ, Randolph GW. Spontaneous and evoked laryngeal electromyography of the thyroarytenoid muscle: a canine model for intraoperative recurrent laryngeal nerve monitoring. Ann Rhinol Laryngol 119:54-63, 2010.

Richer SL, Yelken K, Cunningham MJ, Randolph GW, Franco RA Jr.  Hypopharyngeal Pharyngoplasty for the Management of Piriform Fossa Sinus. Laryngoscope 120(3):500-3, 2010.

Cleary J, Sadow PM, Randolph GW, Palmer E, Lynch T, Nikiforov Y, Wirth L.  Neoadjuvant Treatment of Unresectable Medullary Thyroid Cancer with Sunitinib. Journal of Clinical Oncology, 28(23):e390-2. 2010.

Wu CW, Lu IC, Randolph GW, Kuo WR, Lee KW, Chen CL, Chiang FY. Investigation of optimal intensity and safety of electrical nerve stimulation during intraoperative neuromonitoring of the recurrent laryngeal nerve: a prospective porcine model. Head Neck; 32(10):1295-1301, 2010.
Henneman D, Chang Y, Hodin RA, and Berger DL. Effect of laparoscopy on the indications for adrenalectomy. Arch Surgery 2009; 144:255-259.
Nucera C, Goldfarb M, Hodin R and Parangi S. Role of B-RafV600E in differentiated thyroid cancer and preclinical validation of compounds against B-RafV600E. BBA Reviews on Cancer, 2009 Apr; 1795(2):152-61.
Ren B, Song K, Parangi S, Jin T, Ye M, Humphreys R, Duquette M, Zhang X, Benhaga N, Lawler J, Khosravi-Far R.A double hit to kill tumor and endothelial cells by TRAIL and Antiangiogenic 3 TSR:  Cancer Res. 2009 May 1;69(9):3856-65.

Oneal P, Poylin, V, Mowschenson P, Parangi S, Horowitz G and Hasselgren PO. When initial post excision PTH levels do not fall during  parathyroidectomy:  What to do next, World Journal of Surgery, May 4 2009.
Zhang X, Kazerounian S, Duquette M, Perruzzi C, Nagy JA, Dvorak HF, Parangi S, and Lawler J. Thrombospondin-1 Modulates VEGF Activity at the Receptor Level, FASEB Journal,  June 15 2009.
Mekel M, Stephen A. E., Gaz R. D.,  Hodin R. A., and Parangi S. Thyroid surgery in octogenarians is associated with higher complication rates. Surgery, 2009 Jul 10.

Nucera C, Nehs MC, Mekel M, Zhang X, Hodin R, Lawler J, Nose V, and Parangi, S:  A novel orthotopic mouse model of human anaplastic thyroid carcinoma. Thyroid 2009 Oct; 19 (10):1077-84.
Arora N, Scognamiglio T, Lubitz CC, Moo TA, Kato MA, Zhu B, Zarnegar R, Chen YT, Fahey TJ 3rd. Identification of borderline thyroid tumors by gene expression array analysis. Cancer 2009 Dec 1; 115(23): 5421-31.
Henneman D, Chang Y, Hodin RA, and Berger DL. Effect of laparoscopy on the indications for adrenalectomy. Arch Surgery 2009; 144:255-259.      

Richer SL, Randolph GW.  Management of the recurrent laryngeal nerve in thyroid surgery, Operative Techniques in Otolaryngology. Head and Neck Surgery, 20(10): 29-34, 2009.

Lewis CM, Chang KP, Pitman M, Faquin WC, Randolph GW. Thyroid fine-needle aspiration biopsy: variability in reporting. Thyroid. 19(7):717-23, 2009.

Carty SE, Cooper DS, Doherty GM, Duh QY, Kloos RT, Mandel SJ, Randolph GW, Stack BC Jr, Steward DL, Terris DJ, Thompson GB, Tufano RP, Tuttle RM, Udelsman R. Consensus statement on the terminology and classification of central neck dissection for thyroid cancer. American Thyroid Association Surgery Working Group; American Association of Endocrine Surgeons; American Academy of Otolaryngology-Head and Neck Surgery; American Head and Neck Society. Thyroid 19(11):1153-8, 2009

White WM, Randolph GW. Hartnick CJ, Cunningham MJ. Recurrent laryngeal nerve monitoring during thyroidectomy and related cervical procedures in the pediatric population. Arch Otolaryngol Head Neck Surg.135(1): 88-94, 2009.

Scott AR, Chong PS, Brigger M, Randolph GW, Hartnick CJ. Serial Electromyography of the Thyroarytenoid Muscles in a Canine Model of Vocal Fold Paralysis. Ann Otol Rhinol Laryngol 118:56-66, 2009.

Mihai R, Randolph, GW. Thyroid Surgery, Voice and the Laryngeal Examination-time for Increased Awareness and Accurate   Evaluation. (Editorial). World Journal of Endocrine Surgery 1(1): 1-5, 2009.

Stephen AE, Roth SI, Fardo DW, Finkelstein DM, Randolph GW, Gaz RD, Hodin RA. What does a negative pre-operative sestamibi scan reveal about single gland parathyroid adenomas? Arch Surg 2007; 142:381-386.   

Stephen AE and Hodin RA. Neuroendocrine tumors of the pancreas, excluding gastrinoma. Surg Oncol Clin N Am. 2006; 15:497-510.

Dahia, P.L.M, Ross, K, Wright, M.E, Hayashida, C.Y., Santagata, S, Barontini, M, Kung, A.L, Sanso, G., Powers, J.A, Tischler, A, Hodin, R, Heitritter, S, Moore Jr., F, Dluhy, R., Sosa, J.A., I.T., Ocal, Benn, D.E., Marsh, D.J., Robinson, B.G., Schneider, K., Garber, J, Arum, S.M, Korbonits, M, Grossman, A, Pigny, P, Toledo, S. P. A, Nosé, V, Li, C, Stiles, C.D. A HIF1 regulatory loop links hypoxia and mitochondrial signals in pheochromocytomas. PloS Genet. 2005; 1:72-80.    

Stephen A and Hodin RA. Intraoperative parathyroid hormone measurement: a surgeon’s perspective. College of American Pathologists Today 2004: 18.      


Phitayakorn R.  Minimally Invasive Thyroid Surgery and Thyroid Cancer.  In: Minimally Invasive Thyroidectomy.  Editors: Dimitrios Linos and Woong Youn Chung.  Springer.  2012.

Phitayakorn R.  Peri-operative Corticosteroids.  In: Resident Readiness: Surgery.  Editors: Deb Klamen, Brian C. George, Debra DaRosa, and Alden Harken.  McGraw-Hill.  2013.

Phitayakorn R and Prinz R.  Hypercalcemia.  WISE-MD module.  Fall 2011.

Mekel M and Hodin RA. Goiter. McGraw-Hill’s Manual of Endocrine Surgery, edited by Shane Y. Morita, MD, Alan P.B. Dackiw, MD, PhD, and Martha A. Zeiger, MD. In press.

Stephen AE, Haynes A, Hodin RA. “Adrenal surgery” in Blake MA, Boland G, eds. Adrenal Imaging. New York: Humana Press, In press.

Lubitz CC, Stephen AE. “The Treatment of Hypercalcemic Crisis” in Handbook of Endocrine Surgery, edited by Rebecca Sippel. In press.

McHenry CR, Phitayakorn R.  Follicular Thyroid Adenoma and Carcinoma.  The Oncologist.  In Press.

Phitayakorn R, Faquin W, Wei N, Barbesino G, and Stephen AE. Thyroid-Associated Paragangliomas.  Thyroid.  In Press.

Durán M,Dionigi G, Angelos P, Sitges-Serra A, Phelan E, Randolph G Intraoperative Monitoring of the Recurrent Laryngeal Nerve During Thyroidectomy: A Standardized Approach: Part I. World Journal of Endocrine Surgery, 2011. In press.

Durán M,Dionigi G, Angelos P, Sitges-Serra A, Phelan E, Randolph G Intraoperative
Monitoring of the Recurrent Laryngeal Nerve During Thyroidectomy: A Standardized Approach: Part II. World Journal of Endocrine Surgery, 2011. In press.

Randolph GW. Thyroidectomy- Commentary on chapter in Atlas of Head and Neck Surgery, Cohen J and Clayman G (eds);  Elsevier 2011. In press.

Randolph GW. Paratracheal Nodal Dissection- Commentary on chapter in Atlas of Head and Neck Surgery. Cohen J and Clayman G (eds); Elsevier. In press.

Dralle H, Randolph GW, Lorenz K, Machens A. Thyroid surgery guided by intraoperative neuromonitoring  (Chapter 13) in Surgery of the Thyroid and Parathyroid glands, Springer, 2nd ed. Oertli D, Udelsman R (eds); Jan 2011.

Raffellini M, Lesnik D, Lombardi C, Bellantone R, Randolph G Avoiding Complications in Thyroid and Parathyroid Surgery, in Stell and Maran’s Textbook of Head and Neck Surgery and Oncology Fifth Edition. Watkinson J, Gilbert R (eds); Hodder Arnold Education, London, UK. 2011. In press.

Parangi SP, Phitayakorn R.  Greenwood’s Biography of Disease Series:  Thyroid Diseases.  ABC-CLIO Publishing.  Santa Barbara, CA.  2010.    

McHenry CR, Phitayakorn R.  Difficult Problems in Thyroid Cancer Surgery.  Minerva Chirugica.  2010 Feb; 65(1):83-93.

Bumpous JM, Randolph GW:  The Expanding Utility of Office-Based Ultrasound  for the Head and Neck Surgeon in Otolaryngologic Clinics, Head and Neck Ultrasound,  in Otolaryngology Clinics of North America, Saunders. Sniezek Joeseph, Sofferman Robert. December 2010; 43(6):1203-1208

Randolph GW.  Surgical Anatomy, Intraoperative neural Monitoring and operative management of RLN and SLN. In: Atlas of Endocrine Surgery, Duh QY, Kebebew E, Clark O (eds); Saunders Elsevier, Philadelphia PA, 2010.

Lesnik D, Randolph GW Management of Voice and the Laryngeal Nerves.  In: Endocrine Surgery, Hubbard C, Inabnet W, Lo CY (eds); Springer, 2009.

Lesnik D, O’Leary M A, Noordzij P, Randolph GW.  Surgical Management of Benign Thyroid Disorders in Practical Manual of Thyroid and Parathyroid Disease. Tolley N, Arora A, Tuttle M (eds); Wiley-Blackwell Publishing 2009

Stack B, Randolph GW. Parathyroid Localization.  In: Practical Manual of Thyroid and Parathyroid Disease, Tolley N, Arora A, Tuttle M (eds); Wiley-Blackwell Publishing, 2009.

Lesnik D, Randolph GW, Recurrent Laryngeal Nerve Anatomy and Monitoring, In: Pearls and Pitfalls in Head and Neck Surgery. Cernea C (ed); Karger Medical and Scientific Publishers, 2009.

Price DL, Wong RJ, Randolph GW. Invasive thyroid cancer: Management of the Trachea and Esophagus. Otolaryngol Clin North Am; 41(6):1155-68, 2008.

Stephen A and Hodin RA. Adrenal sparing surgery. In Adrenal Glands, Diagnostic Aspects and Surgical Therapy van Heerden and Linos. Springer-Verlag. 2005; 275-285.