The Endocrine Surgery Unit at Massachusetts General Hospital receives support for its numerous research programs.

Division Support: Endocrine Surgery

R01 DK47186 (Hodin) NIH/NIDDK
Title: Molecular mechanisms of intestinal atrophy/hyperplasia: The long-term objectives of this project are to elucidate the molecular mechanisms, which govern the processes of growth and differentiation within the intestinal epithelia. We are particularly interested in understanding the mechanisms involved in normal crypt-villus enterocyte differentiation, as well as those factors which go awry in a number of gut disease states, including inflammatory conditions, prolonged starvation, as well as systemic trauma and sepsis.
Role: Principal Investigator
R01 DK050623 (Hodin) NIH/NIDDK
Title: Thyroid hormone and the gut: The specific aims of this research project are to elucidate the molecular mechanisms by which thyroid hormone exerts its profound effects upon intestinal epithelial cells. This proposal also deals with the role of IAP as a gut mucosal defense factor.
Role: Principal Investigator
T32 DK007754 (Hodin) NIH
Title: Research training in alimentary tract surgery: The goal of this grant is to provide excellent training for young surgeons interested in a career as a surgeon-scientist in the field of gastrointestinal surgery
Role: Principal Investigator
Amelia Peabody Charitable Foundation (Parangi) Title: Endocrine Tissue Repository and Molecular Diagnostic Laboratory
Developed and used Tissue Banking protocols and database for banking of endocrine tissues from patients undergoing endocrine surgeries at the MGH
Role: Co-Principal Investigator
Polsky Family Fund (Parangi) Title: BRAF and thyroid cancer invasion. Investigate the role of BRAF V600 mutation in thyroid cancer cell invasion and metastasis.
Role: Principal Investigator
Eleanor and Miles Shore 50th year HMS/MGH Department of Surgery Faculty Development Award (Parangi) Title: BRAF Mutations and thyroid cancer invasiveness. Assess effects of knockdown of BRAF on in vivo thyroid cancer invasion.
Role: Principal Investigator
NIH-NCI R01 (Parangi)Title: Inhibition of Angiogenesis by Thrombospondin-1. Evaluate the role of TSP-1 in endothelial apoptosis when combined with TRAIL inhibitors in vivo.
Role: Co-Principal Investigator
NIH-NCI R01 (Parangi)
Title: The Role of BRAF mutation in thyroid cancer invasion.
Role: Principal Investigator
Program in Cancer Outcomes Research Training program (Lubitz) National Cancer Institute-funded, curriculum based, interdisciplinary research fellowship program involves faculty from across the entire Dana-Farber/Harvard Cancer Center and affiliated institutions. The goal of the program is to train pre- and post-doctoral fellows to become leaders in cancer outcomes research.
Role: Fellow
Massachusetts General Hospital Surgery Junior Faculty Award (Lubitz)Title: Assessment and optimization of treatment in patients with papillary thyroid cancer:  A risk-tailored approach
Role: Principal Investigator.
Clinical Innovation Award (Stephen) Massachusetts General Hospital
Title: "Development of a Predictive Multifactor Rule to Minimize Unnecessary Surgery in Patients with Follicular Thyroid Nodules"
Role: Principal Investigator
Harvard Catalyst Advanced Imaging Pilot Grant (Phitayakorn)
Massachusetts General Hospital
Title: Pre-Operative Nodal Staging of Thyroid Cancer Using Ultra-Small Superparamagnetic Iron Oxide Magnetic Resonance Imaging (USPIO MRI): Preliminary Study
Role:  Co-Investigator