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Marc Jay Semigran, MD

Medical Director of the Mass General Heart Failure and Cardiac Transplant Program

Marc Jay Semigran, MD, is Medical Director of the Heart Failure and Cardiac Transplant Program at the Massachusetts General Hospital Heart Center.

  • Phone: 617-726-8862
Department of Medicine


  • Critical Care Center
  • Cardiac Intensive Care Unit
  • Heart Center
  • Heart Failure & Cardiac Transplant Program
  • Transplant Center
  • Heart Transplant
Clinical Interests
Heart failure
Pulmonary hypertension
Heart transplant
Boston: Massachusetts General Hospital
Medical Education
MD, Harvard Medical School
Residency, Massachusetts General Hospital
Fellowship, Massachusetts General Hospital
Board Certifications
Cardiovascular Disease, American Board of Internal Medicine
Internal Medicine, American Board of Internal Medicine
Advanced Heart Failure and Transplant Cardiology, American Board of Internal Medicine
Patient Age Group
Accepting New Patients
Accepting New Patients: Call for Availability

BiographyDr. Semigran is a graduate of the Harvard/MIT Health Sciences and Technology Program and completed Internal Medicine Residency and Cardiology Fellowship Training at Massachusetts General Hospital.  He is Medical Director of theMGH  Heart Failure and Cardiac Transplant Program and conducts clinical and translational reserarch targeting novel approaches to heart failure and  


Hemodynamic effects of inhaled nitric oxide in RV myocardial infarction and cardiogenic shock. J Am Coll Cardiol. 2004;44:793-8.

Hemodynamic effects of sildenafil in patients with CHF and pulmonary hypertension: combined administration with inhaled nitric oxide. Chest. 2005;127:1647-53.

Combined administration of intravenous dipyridamole and inhaled nitric oxide to assess reversibility of pulmonary arterial hypertension in potential cardiac transplant recipients. J Heart Lung Transplant. 2005;24:1950-6.

Sildenafil improves coronary artery patency in a canine model of platelet-mediated cyclic coronary occlusion after thrombolysis. J Am Coll Cardiol. 2006;47:1471-7.

Sildenafil improves exercise hemodynamics and oxygen uptake in patients with systolic heart failure. Circulation. 2007;115:59-66.

Sildenafil improves exercise capacity and quality of life in patients with systolic heart failure and secondary pulmonary hypertension. Circulation. 2007;116:1555-62.

Determinants of ventilatory efficiency in heart failure: the role of right ventricular performance and pulmonary vascular tone. Circ Heart Fail. 2008;1:227-233.

A heartwarming wedding on Ellison 10

MGH Hotline 1.15.10 It's not often one encounters a touching love story within the four walls of the hospital.

A life-saving gift

MGH Hotline 4.2.10 IN THE UNITED STATES ALONE, there are more than 100,000 candidates on the United Network for Organ Sharing organ and tissue waiting list.

The journey home

Lacy Neff, a radio broadcaster from West Virginia, recently underwent a heart transplant as part of his treatment plan for amyloidosis, a rare disease that occurs when amyloid proteins accumulate in the organs. The MGH is one of only seven hospitals in the United States studying cardiac amyloid transplants – and the only one in the Northeast.

Heart Failure and Cardiac Transplant Center
55 Fruit Street
Boston, MA 02114-2696

Phone: 617-726-8862
Fax: 617-726-4105

Heart Failure and Cardiac Transplant Center
55 Fruit Street
Boston, MA 02114-2696

Phone: 617-726-8862
Fax: 617-726-4105

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Request an appointment at the Corrigan Minehan Heart Center

Call the Massachusetts General Hospital Corrigan Minehan Heart Center outpatient access nurse at 866-644-8910