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Sekar Kathiresan, MD, is a cardiologist at the Cardiovascular Disease Prevention Center at the Massachusetts General Hospital Heart Center.
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Altered blood lipids predict risk of myocardial infarction and myocardial infarction is the leading cause of death worldwide. Both blood lipid levels and myocardial infarction are heritable phenotypes. The genes underlying the variability in blood lipids and risk of myocardial infarction are largely unknown. Genes validated in the human population to relate to blood lipids and to risk of myocardial infarction may provide novel diagnostics and new therapeutic targets.
My laboratory seeks to define the genetic basis for blood lipids (high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides) and myocardial infarction (MI). We are focused on three goals: 1) mapping of genetic loci related to lipids and/or myocardial infarction and identifying the causal variants and genes; 2) developing a molecular understanding of how the causal variants and genes lead to phenotype; and 3) applying genetic and functional insights to improve preventive cardiac care. To address the above goals, my laboratory uses a variety of research methodologies and reagants including population genetics, large patient sample collections, genetic association, functional analysis in model organisms, and genetic studies in clinical trials and prospective cohort studies.
View my most recent publications at PubMed
Research at the MGH is interwoven throughout more than 30 departments, centers and units, and is conducted with the support and guidance of the MGH Research Institute. The Research Roundup is a monthly series highlighting studies, news and events.
A study from Massachusetts General Hospital researchers has found that a pattern of gene variants associated with a body type in which weight is deposited around the abdomen increases the risk for type 2 diabetes and coronary heart disease, as well as the incidence of several cardiovascular risk factors.
With two decades of progress in research-focused discoveries, the field of genomics is now poised to enter a new clinical translation phase, where knowledge of the genome and the molecules it encodes may lead to new diagnostics, predictive tools and treatments. With this new phase, comes a new name: The Center for Genomic Medicine (CGM).
A study led by Massachusetts General Hospital investigators has found that, even among those at high genetic risk for heart disease, following a healthy lifestyle can cut in half the probability of a heart attack or similar event.
The 69th meeting of the MGH Scientific Advisory Committee (SAC), on April 6 and 7, focused on the hospital's five thematic research centers.
A study from an international research team finds that familial hypercholesterolemia – a genetic condition that causes greatly elevated levels of LDL cholesterol throughout life – accounts for less than 2 percent of severely elevated LDL in the general population but also increases the risk of coronary artery disease significantly more than does elevated LDL alone.
By combing through the DNA of more than 100,000 people, researchers at Broad Institute, Massachusetts General Hospital, and elsewhere have identified rare, protective genetic mutations that lower the levels of LDL cholesterol — the so-called "bad" cholesterol — in the blood.
By scouring the DNA of thousands of patients, researchers have discovered four rare gene mutations that not only lower the levels of triglycerides but also significantly reduce a person's risk of coronary heart disease
ESTABLISHED IN 2011 by ECOR and the MGH Research Advisory Council, the MGH Research Scholars program provides five years of unrestricted funding to give innovative investigators the flexibility to pursue projects that may lead in unexpected directions. Supported by philanthropic gifts, the program expanded from the first group of five recipients to eight scholars in 2012.
A new paper published online in The Lancet challenges the assumption that raising a person's HDL — the so-called "good cholesterol" — will necessarily lower the risk of a heart attack.
The presentation of the MGH's top research prizes was a highlight of the April 13 Celebration of Science, held in conjunction with the annual Scientific Advisory Committee meeting.
ALL MGHERS are invited to attend the 2011 meeting of the MGH Scientific Advisory Committee (SAC), which will commemorate the hospital's bicentennial with a look back at significant research accomplishments of MGH investigators and examine challenges facing today's research community.
An international research collaboration has identified 13 new gene sites associated with the risk of coronary artery disease and validated 10 sites found in previous studies. Several of the novel sites discovered do not appear to relate to known risk factors, suggesting previously unsuspected mechanisms for cardiovascular disease.
Two papers in the current issue of Nature describe 95 gene variations that contribute to cholesterol and triglyceride levels and reveal the unexpected role of a metabolic pathway in lipid metabolism.
The largest study ever completed of genetic factors associated with heart attacks has identified nine genetic regions - three not previously described - that appear to increase the risk for early-onset myocardial infarction.
An international research team has identified 11 novel locations in the human genome where common variations appear to influence cholesterol or triglyceride levels, bringing the total number of lipid-associated genes to 30.
Sekar Kathiresan, MD, Director of Preventive Cardiology at the Massachusetts General Hospital Heart Center says counteracting your genetic risk is within your control. Learn more about coronary artery disease, who is most at risk and about Mass General's Heart Attack Prevention Program, focused on people with a family history of the disease.
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