Photo of John (John) Wen-Yueh Chen, MD, PhD

John (John) Wen-Yueh Chen, MD, PhD

  • Director, Institute for Innovation in Imaging, Department of Radiology
  • Director, Imaging Clinical Trials, Division of Neuroradiology
  • Associate Professor of Radiology, Harvard Medical School

617-726-8320

 

Overview

Dr. Chen is an associate radiologist and director of Imaging Clinical Trials in the Division of Neuroradiology and director of the Institute for Innovation in Imaging in the Department of Radiology.

Departments

Radiology

Centers & Specialties

Vascular Center

Clinical Interests
  • Neuroradiology
  • multiple sclerosis
  • Neurodegenerative disorders
  • Stroke
  • Brain tumors
  • Advanced MR techniques
  • Stroke Imaging
  • Oncologic imaging
  • Carotid occlusive disease
  • Dementia
  • Memory loss
  • Molecular imaging
  • Imaging contrast agents
Medical Education
  • MD, University of Illinois College of Medicine
  • PhD, University of Illinois College of Medicine
  • Residency, Massachusetts General Hospital
  • Fellowship, Massachusetts General Hospital
Board Certifications
  • Diagnostic Radiology
  • Neuroradiology
Foreign Languages
  • Chinese
  • Taiwanese
Locations
  • Boston: Massachusetts General Hospital
Insurances Accepted
  • Aetna Health Inc.
  • Beech Street
  • Blue Cross Blue Shield - Blue Care 65
  • Blue Cross Blue Shield - Indemnity
  • Blue Cross Blue Shield - Managed Care
  • Blue Cross Blue Shield - Partners Plus
  • Cigna (PAL #'s)
  • Fallon Community HealthCare
  • Great-West Healthcare (formally One Health Plan)
  • Harvard Pilgrim Health Plan - PBO
  • Health Care Value Management (HCVM)
  • Humana/Choice Care PPO
  • MassHealth
  • Medicare
  • Medicare - ACD
  • Neighborhood Health Plan - ACD
  • Neighborhood Health Plan - PBO
  • OSW - Connecticut
  • OSW - Maine
  • OSW - New Hampshire
  • OSW - Rhode Island
  • Private Health Care Systems (PHCS)
  • Railroad Medicare
  • Senior Whole Health
  • TriCare
  • Tufts Health Plan
  • Unicare
  • United Healthcare (non-HMO) - ACD
  • United Healthcare (non-HMO) - PBO

Note: This provider may accept more insurance plans than shown; please call the practice to find out if your plan is accepted.

Patient Age Group
Adult
Gender
Male

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Biography

Dr. Chen is an associate professor of Radiology at Harvard Medical School and attending clinician in the Department of Radiology (Neuroradiology) at Massachusetts General Hospital. He is a graduate of the University of Illinois (MD, PhD in physical chemistry) and completed his radiology residency in 2004 and neuroradiology fellowship at Mass General in 2005. He has won several awards including the Mass General Wyman Award, RSNA and Dana Foundation Awards as well as an NIH K08 award. His current research is supported by two NIH R01 and an R21 grants.

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Research & Publications

Research Summary

My laboratory studies neuroinflammation, combining basic science research with a clinical focus. In particular, we investigate the roles of molecular pathways and innate immune processes related to microglia in multiple sclerosis but also other diseases where CNS inflammation is prominent. A key aspect of our research is in deciphering complex in vivo biology by using innovative molecular imaging technologies, targeted molecular treatments, advanced experimental models as well as human trials. Ultimately we hope advance the diagnosis and treatment of these diseases by developing novel imaging and treatment strategies.

Publications

View my most recent publications at PubMed

Rodriguez E, Nilges M, Weissleder R, Chen JW. Activatable magnetic resonance imaging agents for myeloperoxidase sensing: mechanism of activation, stability, and toxicity. J Am Chem Soc. 2010;132(1):168-77

Ronald JA*, Chen JW*, Chen Y, Hamilton AM, Rodriguez E, Reynolds F, Hegele RA, Rogers KA, Querol M, Bogdanov A, Weissleder R, Rutt BK. Enzyme-Sensitive Magnetic Resonance Imaging Targeting Myeloperoxidase Identifies Active Inflammation in Experimental Rabbit Atherosclerotic Plaques. Circulation. 2009;120(7):592-9

McCann CM, Waterman P, Figueiredo JL, Aikawa E, Weissleder R, Chen JW. Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy. Neuroimage. 2009;45(2):360-9

Breckwoldt M*, Chen JW*, Stangenberg L, Aikawa E, Rodriguez E, Qiu S, Moskowitz M, Weissleder R. Tracking the Inflammatory Response in Stroke in Vivo by Sensing the Enzyme Myeloperoxidase. P Natl Acad Sci U S A. 2008;105 (47):18584-18589

Chen JW, Breckwoldt MO, Aikawa E, Chiang G, Weissleder R. Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis. Brain. 2008;131(Pt 4):1123-33

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Contact

Division of Neuroradiology, Department of Radiology
55 Fruit St
Boston MA, 02114-2696
Phone 1: 617-726-8320
Phone 2: 617-726-1578
Fax: 617-724-3338

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