Photo of John (John) Wen-Yueh Chen, MD, PhD

John (John) Wen-Yueh Chen, MD, PhD


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Clinical Interests
  • multiple sclerosis
  • Neurodegenerative disorders
  • Stroke
  • Tumor
Medical Education
  • MD, University of Illinois College of Medicine
  • PhD, University of Illinois College of Medicine
  • Residency, Massachusetts General Hospital
  • Fellowship, Massachusetts General Hospital
Board Certifications
  • Diagnostic Radiology
  • Neuroradiology
  • Boston: Massachusetts General Hospital
Insurances Accepted
  • Aetna Health Inc.
  • Beech Street
  • Blue Cross Blue Shield - Blue Care 65
  • Blue Cross Blue Shield - Indemnity
  • Blue Cross Blue Shield - Managed Care
  • Blue Cross Blue Shield - Partners Plus
  • Centene/Celticare
  • Cigna (PAL #'s)
  • Fallon Community HealthCare
  • Great-West Healthcare (formally One Health Plan)
  • Harvard Pilgrim Health Plan - PBO
  • Health Care Value Management (HCVM)
  • Humana/Choice Care PPO
  • Medicaid
  • Medicare
  • Medicare - ACD
  • Neighborhood Health Plan - ACD
  • Neighborhood Health Plan - PBO
  • OSW - Connecticut
  • OSW - Maine
  • OSW - New Hampshire
  • OSW - Rhode Island
  • Private Health Care Systems (PHCS)
  • Railroad Medicare
  • Senior Whole Health
  • TriCare
  • Tufts Health Plan
  • Unicare
  • United Healthcare (non-HMO) - ACD
  • United Healthcare (non-HMO) - PBO
Patient Age Group

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Dr. Chen is an Associate Professor at Harvard Medical School and Attending Clinician (Neuroradiology) at Mass General Hospital. Dr. Chen is a graduate of the University of Illinois (MD, PhD in physical chemistry) and completed his radiology residency in 2004 and neuroradiology fellowship at MGH in 2005. He has won several awards including the MGH Wyman Award, RSNA and Dana Foundation Awards, as well as an NIH K08 award. His current research is supported by two NIH R01 and an R21 grants.

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Research & Publications

Research Summary

My laboratory studies neuroinflammation, combining basic science research with a clinical focus. In particular, we investigate the roles of molecular pathways and innate immune processes related to microglia in multiple sclerosis but also other diseases where CNS inflammation is prominent. A key aspect of our research is in deciphering complex in vivo biology by using innovative molecular imaging technologies, targeted molecular treatments, advanced experimental models as well as human trials. Ultimately we hope advance the diagnosis and treatment of these diseases by developing novel imaging and treatment strategies.


Selected publications:

Rodriguez E, Nilges M, Weissleder R, Chen JW
Activatable magnetic resonance imaging agents for myeloperoxidase sensing: mechanism of activation, stability, and toxicity.
J Am Chem Soc. 2010;132(1):168-77

Ronald JA*, Chen JW*, Chen Y, Hamilton AM, Rodriguez E, Reynolds F, Hegele RA, Rogers KA, Querol M, Bogdanov A, Weissleder R, Rutt BK
Enzyme-Sensitive Magnetic Resonance Imaging Targeting Myeloperoxidase Identifies Active Inflammation in Experimental Rabbit Atherosclerotic Plaques.
Circulation. 2009;120(7):592-9

McCann CM, Waterman P, Figueiredo JL, Aikawa E, Weissleder R, Chen JW
Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy.
Neuroimage. 2009;45(2):360-9

Breckwoldt M*, Chen JW*, Stangenberg L, Aikawa E, Rodriguez E, Qiu S, Moskowitz M, Weissleder R
Tracking the Inflammatory Response in Stroke in Vivo by Sensing the Enzyme Myeloperoxidase
P Natl Acad Sci U S A. 2008;105 (47):18584-18589

Chen JW, Breckwoldt MO, Aikawa E, Chiang G, Weissleder R
Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis.
Brain. 2008;131(Pt 4):1123-33

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Radiological Associates
55 Fruit Street
Boston MA, 02114-2696
Phone: 617-726-8320
Fax: 617-724-3338

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