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John Wen-Yueh (John) Chen, MD, PhD

  • Phone: 617-726-8320
Departments
Radiology
Clinical Interests
multiple sclerosis
Neurodegenerative disorders
Stroke
Tumor
Locations
Boston: Massachusetts General Hospital
Medical Education
MD, University of Illinois College of Medicine
PhD, University of Illinois College of Medicine
Residency, Massachusetts General Hospital
Fellowship, Massachusetts General Hospital
Board Certifications
Diagnostic Radiology, American Board of Radiology
Diagnostic Radiology, American Board of Radiology
Gender
Male
Foreign Languages
Chinese
Taiwanese
Patient Age Group
Adult
Accepting New Patients
Yes

BiographyDr. Chen is an Associate Professor at Harvard Medical School and Attending Clinician (Neuroradiology) at Mass General Hospital. Dr. Chen is a graduate of the University of Illinois (MD, PhD in physical chemistry) and completed his radiology residency in 2004 and neuroradiology fellowship at MGH in 2005. He has won several awards including the MGH Wyman Award, RSNA and Dana Foundation Awards, as well as an NIH K08 award. His current research is supported by two NIH R01 and an R21 grants.

Research

My laboratory studies neuroinflammation, combining basic science research with a clinical focus. In particular, we investigate the roles of molecular pathways and innate immune processes related to microglia in multiple sclerosis but also other diseases where CNS inflammation is prominent. A key aspect of our research is in deciphering complex in vivo biology by using innovative molecular imaging technologies, targeted molecular treatments, advanced experimental models as well as human trials. Ultimately we hope advance the diagnosis and treatment of these diseases by developing novel imaging and treatment strategies.

Publications
Selected publications:


Rodriguez E, Nilges M, Weissleder R, Chen JW
Activatable magnetic resonance imaging agents for myeloperoxidase sensing: mechanism of activation, stability, and toxicity.
J Am Chem Soc. 2010;132(1):168-77

Ronald JA*, Chen JW*, Chen Y, Hamilton AM, Rodriguez E, Reynolds F, Hegele RA, Rogers KA, Querol M, Bogdanov A, Weissleder R, Rutt BK
Enzyme-Sensitive Magnetic Resonance Imaging Targeting Myeloperoxidase Identifies Active Inflammation in Experimental Rabbit Atherosclerotic Plaques.
Circulation. 2009;120(7):592-9

McCann CM, Waterman P, Figueiredo JL, Aikawa E, Weissleder R, Chen JW
Combined magnetic resonance and fluorescence imaging of the living mouse brain reveals glioma response to chemotherapy.
Neuroimage. 2009;45(2):360-9

Breckwoldt M*, Chen JW*, Stangenberg L, Aikawa E, Rodriguez E, Qiu S, Moskowitz M, Weissleder R
Tracking the Inflammatory Response in Stroke in Vivo by Sensing the Enzyme Myeloperoxidase
P Natl Acad Sci U S A. 2008;105 (47):18584-18589

Chen JW, Breckwoldt MO, Aikawa E, Chiang G, Weissleder R
Myeloperoxidase-targeted imaging of active inflammatory lesions in murine experimental autoimmune encephalomyelitis.
Brain. 2008;131(Pt 4):1123-33

Radiological Associates
55 Fruit Street
Boston, MA 02114-2696

Phone: 617-726-8320
Fax: 617-724-3338

Radiological Associates
55 Fruit Street
Boston, MA 02114-2696

Phone: 617-726-8320
Fax: 617-724-3338

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