PET-CT

PET Core Laboratory

The PET (positron emission tomography) Core Laboratory provides a full range of technical and professional services for the design and execution of programs using PET.
Contact us by email

(617) 726-8353

Overview

The PET Core Laboratory at Massachusetts General Hospital provides a full range of technical and professional services for the design and execution of programs using Positron Emission Tomography (PET).

The PET Core Facility provides the required facilities and personnel on a per study basis to allow investigators to use PET without requiring them to acquire the needed special expertise and equipment.

 

Group Members

Personnel

Georges El Fakhri, PhD
Director, PET Core & Co-Director, NMMI
Phone: (617) 726-9640
Fax: (617) 726-6165
Email: elfakhri@pet.mgh.harvard.edu


Daniel Yokell, Pharm.D.
Manager, PET Production Chemistry
Phone: (617) 643-7541
Fax: (617) 726-5123
Email: dyokell@partners.org

Facilities & Equipment

Location of Core:

The cyclotron/radiochemistry component of the PET Core is located in the basement of the Edwards Building. The PET Research Imaging Laboratories consist of imaging cameras for human and large-animals imaging including a dedicated brain PET/CT and whole body PET, PET/CT and SPECT/CT on the MGH Main Campus, as well as a dedicated MicroPET/CT for animal imaging located at the Charlestown Navy Yard.

Major Equipment:

  • Automated Radiochemical Synthesis Systems
  • PC4096 Large Bore PET Scanner
  • Exact HR+ Large Bore PET Scanner
  • E.cam (Siemens) SPECT Systems and Planar Gamma Cameras
  • Siemens PET/CT Scanner, Symbia SPECT/CT
  • NeuroPET/CT dedicated high sensitivity brain scanner
  • VISTA small animal micro PET/CT

Services

F-18

  • FDG*
  • FES (estrogen receptor)†
  • T807 (tau protein)‡
  • FPEB (mGlur5)
  • BFPET (myocardial perfusion)
  • GE180 (TSPO/PBR)†
  • FLT (cellular proliferation)†

C-11

  • PiB (amlyoid)‡
  • Altropane (Dopamine transport)
  • Raclopride (D2/D3 receptor imaging)
  • Methionine (amino acid uptake)†
  • Acetate  (fatty acid synthase)

CO (gas)

  • Rolipram  (PDE-4 receptor imaging)
  • P943 (5-HT1B)

N-13

  • Ammonia*
  • N2 in Saline (lung perfusion imaging)

O-15

  • C15O2 (blood flow imaging)

Currently in Development/Validation for Human Use at the MGH PET Core

  • F-18
  • THK 5351/GE-216 (tau protein)†
  • FMISO (hypoxia)*
  • MK-6240 (tau protein)‡
  • GE179 (NMDA) ‡

C-11

  • PBR-28 (TSPO/PBR)†
  • (S,S)-[11C]Methylreboxetine (MeNR/MRB) – targets NET†

 

Fee Schedule

Service Internal Fee—Partners Standard Internal Fee—Partners-Industry External Fee—Academic External Fee—Industry
11C Compounds - no QC non-human $1,983 $2,974 $2,855.52 Please contact PET Core for rates
11C Compounds - QC human $3,065 $4,597 $4,413.60 Please contact PET Core for rates
13N2 Lung Study - no QC non-human $1,451 $2,176 $2,089.44 Please contact PET Core for rates
13N2 Lung Study - QC human $2,532 $3,798 $3,646.08 Please contact PET Core for rates
13N2/13NH3 Saline/Aerosol $3,708 $5,562 $5,339.52 Please contact PET Core for rates
13NH3 Cardiac Blood Flow $3,904 $5,856 $5,621.76 Please contact PET Core for rates
15O Water Brain Blood Flow $2,716 $4,074 $3,911.04 Please contact PET Core for rates
18F Compounds - no QC non-human $2,008 $3,012 $2,891.52 Please contact PET Core for rates
18F Compounds - QC human $3,090 $4,635 $4,449.60 Please contact PET Core for rates
18F dose human $1,854 $2,781 $2,669.76 Please contact PET Core for rates
18F dose non-human $978 $1,467 $1,408.32 Please contact PET Core for rates
18F FDG - no QC non-human $1,054 $1,581 $1,517.76 Please contact PET Core for rates
18F FDG - QC human $2,136 $3,204 $3,075.84 Please contact PET Core for rates
18F Imaging only $2,008 $3,012 $2,891.52 Please contact PET Core for rates
Consent charge $100 $150 $144 Please contact PET Core for rates
CT angiography $1,606 $2,409 $2,312.64 Please contact PET Core for rates
Cyclotron beam time (per hour) $721 $1,081 $1,038.24 Please contact PET Core for rates
IRB renewal $3,574 $5,361 $5,146.56 Please contact PET Core for rates
Micro PET imaging only (up-to-2 hrs) $350 $525 $504 Please contact PET Core for rates
Micro PET including radiotracer (up-to-2 hrs) $824  $1,236 $1,186.56 Please contact PET Core for rates
MicroPET additional hour $103 $154 $148.32 Please contact PET Core for rates
Phantom Imaging $1,550 $2,325 $2,232 Please contact PET Core for rates
Radionuclidic Purity Testing $384 $576 $552.96 Please contact PET Core for rates
Regulatory Submission $10,570 $15,855 $15,220.80 Please contact PET Core for rates
SPECT $2,060 $3,090 $2,966.40 Please contact PET Core for rates
SPECT-CT $2,150 $3,225 $3,096 Please contact PET Core for rates
Start-up fee $7,416 $11,124 $10,679.04 Please contact PET Core for rates
Technician training / Site qualification (per hour) $309 $463 $444.96 Please contact PET Core for rates
Validation of radiotracer for animal use $15,450 $23,175 $22,248 Please contact PET Core for rates
Validation of radiotracer for human use $22,660 $33,990 $32,630 Please contact PET Core for rates

 

Radio pharmaceuticals

F-18

FDG*

FES (estrogen receptor)†

T807 (tau protein)‡

FPEB (mGlur5)

BFPET (myocardial perfusion)

GE180 (TSPO/PBR)†

FLT (cellular proliferation)†

 

C-11

PiB (amlyoid)‡

Altropane (Dopamine transport)

Raclopride (D2/D3 receptor imaging)

Methionine (amino acid uptake)†

Acetate (fatty acid synthase)

CO (gas)

Rolipram (PDE-4 receptor imaging)

P943 (5-HT1B)

 

N-13

Ammonia*

N2 in Saline (lung perfusion imaging)

 

O-15

C15O2 (blood flow imaging)

 

Currently in Development/Validation for Human Use at the MGH PET Core

 

F-18

THK 5351/GE-216 (tau protein)‡

FMISO (hypoxia)‡

MK-6240 (tau protein)‡

GE179 (NMDA) ‡

 

C-11

PBR-28 (TSPO/PBR)‡

(S,S)-[11C]Methylreboxetine (MeNR/MRB) – targets NET

*FDA approved
†Active IND
‡Pending/Planned IND

Getting Started

Investigators from the academic community, research laboratories and industry are welcome to use the PET Core services. Research services are accessed through contact with the professional staff leading to formalization of a research plan and subsequent review by the Scientific Management Committee. Clinical services are accessed by direct arrangement with the medical staff of the radiology department.

To access the core, please contact Chris Shambaugh at(617) 726-8353or by email at cshambaugh@partners.org.

The PET Core has mechanisms available for pilot studies.

Contact us by email

(617) 726-8353

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