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People & Location
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The Lesser lab is ultimately interested in understanding how bacterial pathogens cause infection and disease. Current work focuses on identifying proteins that intracellular bacteria use to manipulate eukaryotic host cell processes. Furthermore, we exploit the powerful array of experimental tools available for the model eukaryote, Saccharomyces cerevisiae, to determine and dissect the cellular processes targeted by these proteins. S. cerevisiae is an ideal system for conducting multidisciplinary studies because of its relatively small genome, genetic tractability, well-developed post-genomic tools, and numerous databases of information on basic cellular processes. In addition, we are developing Proteome Explorer, new network visualization software, to assist in the interpretation of the large data sets that our screens generate. Studies in yeast are beginning to generate models of host pathogen interactions that we are currently testing in physiologically model of disease.
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