Dr. Arnaout is a physician-scientist in the Division of Nephrology at Massachusetts General Hospital in Boston. He is also Professor of Medicine at Harvard Medical School.
BiographyDr. Arnaout received his medical degree with distinction from the American University of Beirut, Lebanon. He served on the medical staff of the American University of Beirut Hospital as an intern and resident in Medicine before moving to Johns Hopkins where he completed his residency. He then moved to Harvard where he finished fellowships in immunology and nephrology at Boston's Childrens Hospital and Brigham and Women's Hospital. He currently serves as a Physician-Scientist in the Division of Nephrology at Massachusetts General Hospital.
Major research activities in Dr. Arnaout's laboratory focus on dissecting the role of leukocyte adhesion in inflammation and immune injury and on elucidating the basic cellular defects in Autosomal Dominant Polycystic Kidney Disease (ADPKD).
The leukocyte integrins are cell surface receptors that mediate adhesio-dependent functions in all cell types including leukocytes, where they mediate leukocyte homing to tissues and organs a vital component of host defense against pathogens. Deregulated activation of integrins leads to pathologic inflammation. A major focus is to define the structural basis of integrin regulation, which should help in developing novel drugs to counter inflammatory diseases.
Defective regulation of tube diameter is the basic defect in ADPKD, leading to cysts in tubules and blood vessels. Mutations in one of two genes, PKD1 or PKD2 is the underlying genetic cause, but how these proteins function and are regulated is incompletely understood and is the focus of our research.
MGH investigators may have found a way to solve a problem that has plagued a group of drugs called ligand-mimicking integrin inhibitors, which have the potential to treat conditions ranging from heart attacks to cancer metastasis.
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