Jay Alan Fishman, MD, is Co-Director of the Mass General Transplant Center and directs active clinical, clinical research and basic science programs in the pathogenesis of infectious diseases related to solid organ and stem cell transplantation.
Jay A. Fishman is Director of the Transplant Infectious Diseases and Compromised Host Program at the Mass General, Associate Director of the Mass General Transplant Center and Professor of Medicine at Harvard Medical School in Boston, MA. Dr. Fishman is an internationally recognized expert in infectious diseases related to transplantation and has trained many of the leaders in this field. He has a special interest in molecular diagnostics, transplant virology and mycology, and in medical education.
He is Past-President of the American Society of Transplantation and has served on the Boards of the International Transplant Infectious Disease and International Xenotransplanation Societies and of the Immunocompromised Host Society and is a frequent contributor at national and international symposia. He has been recognized by the Clinical Career Achievement Award of the American Society of Transplantation and the Transplantation Society Award for Transplant Infectious Disease. Dr. Fishman's clinical and research interests focus on the pathogenesis and prevention of infection in the immunocompromised host. His NIH-funded laboratory is investigating infectious disease issues related to xenotransplantation and the role of viral infections in transplantation.
Dr. Fishman's research is focused on the pathogenesis of infections in immunocompromised hosts including:
Xenotransplantation: Studies of infection associated with interspecies transplantation have resulted in the identification of a variety of potential pathogens in pig-to-primate transplantation. This laboratory has achieved the first cloning and full-length sequencing of endogenous retroviruses from swine (PERV). A recombinant form of PERV (A-C) has been identified that is infectious for human cells in vitro. The mechanisms underlying this recombination and infectivity for human cells are under investigation.
Viral Infection in transplantation: Chronic allograft vasculopathy (CAV) of the coronary vasculature is a major cause of death in cardiac transplant patients. In murine heart transplantation, both T-cells and NK cells are involved in the pathogenesis of cardiac graft vaculopathy. We have demonstrated that Lymphocytic Choriomeningitis Virus (LCMV) induces CAV in T-cell deficient mice. We have isolated NK cell activity using RAG1-/- mice, which are deficient in T and B cells, but have an intact NK cell population. LCMV induced CAV in parental to F1 cardiac transplants in RAG1-/-mice.
Clinical Investigation: An active program in clinical investigation is in collaboration with the Transplantation and the Hematopoietic and Stem Cell Transplant Units. Studies of the pathogenesis of viral infections, the role of cytomegalovirus, novel viral vaccines, and of prophylaxis for bacterial, viral, and fungal infections in the immunocompromised host are ongoing.
Martin SI, Wilkinson RA, Fishman JA. Genomic presence of recombinant porcine endogenous retrovirus in transmitting miniature swine. Virology J., Virology Journal 2006, 3:1743-422
Doucette K, Dor FJMF, Wilkinson RA, Martin SI, Huang CA, Cooper DKC, Sachs DH, Fishman JA. Gene Expression Of Porcine Lymphotrophic Herpesvirus-1 (PLHV-1) In Miniature Swine With Posttransplant Lymphoproliferative Disorder. Transplantation 2007, 83: 87-90.
Issa NC, Fishman JA. Infectious Complications of Anti-Lymphocyte Therapies in Solid Organ Transplantation. Clin Infect Dis, 2009;48:77R-786.
Horn DL, Fishman JA, Steinbach WJ, Anaissie EJ, Marr KA, Olyaei AJ, Pfaller MA, Weiss MA, Webster KM, Neofytos D. Creation of a Comprehensive Registry for Prospective Real-Time Data Collection and Analysis Using a Web-based e-CRF. J Biomedical Informatics, in press.
Saidi RF, Elias N, Kawai T, Hertl M, Farrell M-L, Goes N, Wong W, Hartono C, Fishman JA, Kotton C, Tolkoff-Rubin N, Delmonico FL, Cosimi AB, Ko DSC. Outcome of Kidney Transplantation Using Expanded Criteria Donors and Donation After Cardiac Death Kidneys: Realities and Costs. American J Transplant 2007, 7:1-6.
Kawai T, Cosimi AB, Spitzer TR, Tolkoff-Rubin N, Suthanthiran M, Saidman SL, Shaffer J, Preffer FI, Ding R, Sharma V, Fishman JA, Dey BR, Ko DSC, Hertl M, Goes NB Wong W, Williams WW, Colvin RB, Sykes M, Sachs DH.HLA-Mismatched Renal Transplantation without Maintenance Immunosupression, New Eng J Medicine, 2008, 358:353-361.
MGH Hotline 5.08.09 Members of the MGH Transplant Center and the New England Organ Bank (NEOB) gathered in the Bulfinch Tents April 28 to celebrate National Donate Life Month, established to recognize the generosity of those who have saved lives through the donation of an organ, tissue, marrow or blood.
Clinicians at the Transplant Center received a National Health Information Award for developing an outstanding patient education book and streamlining the patient evaluation process.
MGH Hotline 12.3.10 Members of the MGH Transplant Center gathered in the Bigelow Amphitheater Nov. 17 to hear Joren Madsen, MD, DPhil, director of the MGH Transplant Center; Jay A. Fishman, MD, associate director of the center; and Debra J. Doroni, MBA, executive director of the center and the Department of Surgery, unveil the Transplant Center's new strategic plan.
In many countries, including the United States, it is illegal to procure an organ for transplant from an HIV-infected person. But these laws may soon be reevaluated since it is now possible to better manage HIV and because the demand for organs far exceeds supply.