Physician Photo

Matthew R. (Matthew) Smith, MD, PhD

Director, Genitourinary Malignancies Program

Matthew Smith, M.D., Ph.D. is the Director of the Genitourinary Malignancies Program at the Massachusetts General Hospital Cancer Center. His clinical practice and research program focus on the management of prostate cancer.

  • Phone: 617-724-5257
Department of Medicine


  • Cancer Center
  • Prostate Cancer
  • Genitourinary Oncology
Clinical Interests
Prostate cancer
Boston: Massachusetts General Hospital
Medical Education
MD, Duke University School of Medicine
PhD, Duke University School of Medicine
Residency, Brigham and Women's Hospital
Fellowship, Dana Farber Cancer Institute
Board Certifications
Medical Oncology, American Board of Internal Medicine
Patient Age Group
Accepting New Patients
Accepting New Patients

BiographyDr. Matthew R. Smith is Director of the Genitourinary Oncology Program at Massachusetts General Hospital Cancer Center and an Associate Professor of Medicine at Harvard Medical School.He graduated summa cum laude from Canisius College with a B.A. in biochemistry. He received his MD and PhD degrees from Duke University School of Medicine. He trained in Internal Medicine at Brigham and Women's Hospital.He completed a fellowship in Medical Oncology at Dana Farber Cancer Institute and a postdoctoral fellowship at Massachusetts Institute of Technology.

He is an internationally recognized expert in prostate cancer. He has published extensively on treatment and prevention of bone metastases and prostate cancer survivorship. He has authored more than 150 peer-reviewed articles including manuscripts in New England Journal of Medicine, Journal of Clinical Oncology, Cancer, Journal of Clinical Endocrinology and Metabolism, and Clinical Cancer Research. His research is supported by competitive grants and awards from the National Institutes of Health, Lance Armstrong Foundation Research Award, and the Prostate Cancer Foundation.

ResearchDr. Smith leads a clinical research program in prostate cancer focused on cancer survivorship, treatment and prevention of bone metastases, and novel therapeutics. With a multidisciplinary research team, he identified previously unrecognized adverse effects of androgen deprivation therapy including osteoporosis, sarcopenia, obesity, lipid alterations, insulin resistance, and greater risks for fractures, diabetes, and cardiovascular disease. These novel observations have provided fundamental insights in the management of prostate cancer and informed the design of global clinical trials to prevent treatment-related morbidity in prostate cancer survivors. His research has contributed to the approval of new drugs to prevent skeletal morbidity in men with prostate cancer. He leads international studies to prevent and treat bone metastases. He leads an active clinical research program in novel therapy for prostate cancer. His research program is supported by principal investigator peer-reviewed research funding from federal, investigator-initiated industry, and foundation grants including an NIH K24 mid-career investigator award and a Prostate Cancer Foundation Transformational grant. He has authored more than 70 original research reports and more than 80 reviews and book chapters on prostate cancer.

New drug could significantly improve patient quality of life:

Matthew Smith, MD, PhD, of the Massachusetts General Hospital Cancer Center, led a study on a new targeted therapy to stop bone loss, increase bone density and prevent spinal fractures in men receiving androgen-deprivation therapy for prostate cancer.

Denosumab increases bone density, cuts fracture risk in prostate cancer survivors

Twice-yearly treatment with denosumab, a new targeted therapy to stop bone loss, increased bone density and prevented spinal fractures in men receiving androgen-deprivation therapy for prostate cancer.

Denosumab delays development of prostate cancer bone metastasis

An international clinical trial has found that treatment with a drug that suppresses the normal breakdown of bone can delay the development of bone metastases in men with prostate cancer.

Genitourinary Cancer Center
55 Fruit Street
Boston, MA 02114

Phone: 617-724-5257
Fax: 617-726-4899