Photo of Theofanie  Mela, MD

Theofanie Mela, MD

  • Director, Pacer and ICD Lab


Accepting New Patients





Centers & Specialties

Heart Center

Clinical Interests
  • Cardiac pacing
  • Sudden cardiac death
  • Supraventricular tachycardias
  • Atrial fibrillation
  • Cardiac arrhythmia
  • Cardiac resynchronization therapy (CRT)
  • Implantable cardioverter defibrillators (ICD) and pacemakers
Medical Education
  • MD, University of Athens School of Medicine
  • Residency, St. Elizabeth's Medical Center
  • Fellowship, Massachusetts General Hospital|Fellowship, UMass Memorial Medical Center
Board Certifications
  • Clinical Cardiac Electrophysiology
  • Boston: Massachusetts General Hospital
Insurances Accepted
  • Aetna Health Inc.
  • Beech Street
  • Blue Cross Blue Shield - Blue Care 65
  • Blue Cross Blue Shield - Indemnity
  • Blue Cross Blue Shield - Managed Care
  • Blue Cross Blue Shield - Partners Plus
  • Centene/Celticare
  • Cigna (PAL #'s)
  • Fallon Community HealthCare
  • Great-West Healthcare (formally One Health Plan)
  • Harvard Pilgrim Health Plan - PBO
  • Health Care Value Management (HCVM)
  • Humana/Choice Care PPO
  • Medicaid
  • Medicare
  • Medicare - ACD
  • Neighborhood Health Plan - ACD
  • Neighborhood Health Plan - PBO
  • OSW - Connecticut
  • OSW - Maine
  • OSW - New Hampshire
  • OSW - Rhode Island
  • OSW - Vermont
  • Private Health Care Systems (PHCS)
  • Railroad Medicare
  • Railroad Medicare - ACD
  • Senior Whole Health
  • TriCare
  • Tufts Health Plan
  • Unicare
  • United Healthcare (non-HMO) - ACD
  • United Healthcare (non-HMO) - PBO
Patient Age Group

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I completed my medical residency in 1995 (St. Elizabeth's Medical Center, Boston, MA), cardiology fellowship in 1998 (University of Massachusetts Medical Center, Worcester, MA) and cardiac electrophysiology fellowship in 1999 (Massachusetts General Hospital, Boston, MA).

I am currently an Assistant Professor in Medicine, Harvard Medical School, Boston, MA. I am a Staff Cardiac Electrophysiologist and the Director of Pacemaker and ICD Clinic, Massachusetts General Hospital, Boston, MA.

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Research & Publications

Research Summary

Block HF Clinical Trial. This is a multicenter study to test the hypothesis that patients with mild to moderate symptoms of heart failure, NYHA Class I, II, and III, some degree of left ventricular dysfunction (LVEF < 50%) and AV block will benefit from biventricular pacing compared to right ventricular pacing, as evidenced by a slowing in the progression of heart failure in patients receiving biventricular pacing. This benefit will be demonstrated using a composite endpoint of mortality, morbidity and cardiac function.

VEST. This is a multicenter NIH funded study looking into reducing the risk of sudden cardiac death in post-MI patients who have a reduced LVEF < 35%. These patients will be randomized to receive a LifeVest external defibrillator as opposed to medical therapy.

Role: Principal investigator for Massachusetts General Hospital.


Noseworthy PA, Rosenberg MA, Fifer MA, Palacios IF, Lowry PA, Ruskin JN, Sanborn DM, Picard MH, Vlahakes GJ, Das S, Mela T. Ventricular arrhythmia following alcohol septal ablation for obstructive hypertrophic cardiomyopathy. AJC 2009;104(1):128-132.

Merchant FM, Heist EK, McCarty D, Kumar P, Das S, Blendea D, Ellinor PT, Mela T, Picard MH, Ruskin JN, Singh JP. Impact of segmental left ventricle lead position on cardiac resynchronization therapy outcomes. Heart Rhythm. 2010 May;7(5):639-44.

Complication Rates Associated with Pacemaker or Implantable Cardioverter-Defibrillator Generator Replacements and Upgrade Procedures. Results from the REPLACE Registry. Circ 2010: 122;1553-1561.

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News & Events


Electrophysiology Lab/Arrhythmia Service
55 Fruit Street
Boston MA, 02114-2696
Phone: 617-726-4662
Fax: 617-726-3852

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