Photo of Wayne G. Shreffler, MD, PhD

Wayne G. Shreffler, MD, PhD

  • Chief, Pediatric Allergy & Immunology
  • Director, Food Allergy Center
  • Principal Investigator, Center for Immunology and Inflammatory Diseases


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The mission of the food allergy center is to provide the best possible care through multidisciplinary care and research.



Centers & Specialties

MassGeneral Hospital for Children

Clinical Interests
  • Food allergy
  • Eosinophilic gastrointestinal disease
  • Eczema (atopic dermatitis)
  • Asthma
  • Immunotherapy
Medical Education
  • MD, PhD, New York University School of Medicine
  • Residency, Montefiore Hospital & Medical Center
  • Fellowship, Mount Sinai Hospital Medical Center
Board Certifications
  • Allergy & Immunology
  • Boston: Massachusetts General Hospital
Patient Gateway
Yes, learn more
Insurances Accepted
  • Aetna Health Inc.
  • Beech Street
  • Blue Cross Blue Shield - Blue Care 65
  • Blue Cross Blue Shield - Indemnity
  • Blue Cross Blue Shield - Managed Care
  • Blue Cross Blue Shield - Partners Plus
  • Cigna (PAL #'s)
  • Fallon Community HealthCare
  • Great-West Healthcare (formally One Health Plan)
  • Harvard Pilgrim Health Plan - ACD
  • Harvard Pilgrim Health Plan - PBO
  • Health Care Value Management (HCVM)
  • Humana/Choice Care PPO
  • MassHealth
  • Medicare
  • Medicare - ACD
  • Neighborhood Health Plan - ACD
  • Neighborhood Health Plan - PBO
  • OSW - Connecticut
  • OSW - Maine
  • OSW - New Hampshire
  • OSW - Rhode Island
  • Private Health Care Systems (PHCS)
  • Senior Whole Health
  • TriCare
  • Tufts Health Plan
  • Unicare
  • United Healthcare (non-HMO) - ACD
  • United Healthcare (non-HMO) - PBO
Patient Age Group

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Dr. Shreffler has developed a highly integrated research andclinical program to better understand the pathogenic mechanisms of food allergyand asthma and provide the best current and future care. The Shreffler laboratory focuses on the characterization ofcellular and humoral immune response to dietary antigens and the mechanisms ofallergen-induced Th2 sensitization and oral tolerance. Areas of activeinvestigation include 1) the mechanisms of allergenic dendritic cell (DC)activation by allergens and the DC signals that induce Th2 differentiation; 2)the role of regulatory T cells in natural and immunotherapy-induced oraltolerance; 3) the role of IgE diversity and basophil activation and theirregulation in both the effector response and in adaptive immune deviation inthe context of food allergy and asthma.

Dr. Shreffler received his MD and PhD degrees from New YorkUniversity and his Pediatrics training at the Albert Einstein College ofMedicine. He completed his fellowship in Allergy & Immunology at the MountSinai School of Medicine in 2003. He is board certified in Pediatrics andAllergy/ Immunology and is a fellow of the American Academy of Allergy, Asthmaand Immunology. He sits on the editorial board for the Journal of Allergy andClinical Immunology, the leading specialty journal for his field. 

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Research & Publications

Research Summary

The Shreffler laboratory focuses on thecharacterization of cellular and humoral immune response to dietary antigensand the mechanisms of allergen-induced Th2 sensitization and oral tolerance.Areas of active investigation include 1) the mechanisms of allergenic dendriticcell (DC) activation by allergens and the DC signals that induce Th2differentiation; 2) the role of regulatory T cells in natural andimmunotherapy-induced oral tolerance; 3) the role of IgE diversity and basophilactivation and their regulation in both the effector response and in adaptiveimmune deviation in the context of food allergy and asthma. We primarily workwith human samples, often in conjunction with clinicalinterventional or observational studies, to interrogate both the innate andadaptive immune responses to major dietary and aeroallergens.

Working together with numerous collaboratorsincluding from the Consortium for Food AllergyResearch , the Inner City Asthma Consortium and our own newly established FoodAllergy Center at MGH, we are adapting the use of polychromatic flowcytometry, peptide microarray-based humoral immune profiling and systemsbiology approaches to uniquely characterize the phenotype and function of allergen-specificT and B cell responses and the regulations of effector cells in pediatric foodallergy and asthma.

Also important is the effort to understand whysome food proteins are potent allergens. In other words, what are themechanisms that influence early immune fate decisions to allergens and theintrinsic properties of those allergens that facilitate an allergic response. Weare studying this in human and murine model systems.


View my most recent publications at PubMed

see PubMed link.

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News & Events


Pediatric Allergy and Pulmonary Unit
275 Cambridge Street
CPZS 557
Boston MA, 02114-3108
Phone 1: 617-726-8707
Fax: 617-724-2803

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