Photo of Flavia V. Castelino, MD

Flavia V. Castelino, MD

  • Assistant Professor of Medicine, Harvard Medical School
  • Assistant Physician, Massachusetts General Hospital


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Clinical Interests
  • Scleroderma/Systemic sclerosis
  • Connective tissue associated interstitial lung disease
  • Raynaud's phenomenon
  • Rheumatoid arthritis
  • Dermatomyositis
Medical Education
  • MD, SUNY at Syracuse (Upstate) College of Medicine
  • Residency, Northwestern Memorial Hospital
  • Fellowship, Massachusetts General Hospital
Board Certifications
  • Internal Medicine
  • Rheumatology
  • Boston: Massachusetts General Hospital
Patient Gateway
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Insurances Accepted
  • Aetna Health Inc.
  • Beech Street
  • Blue Cross Blue Shield - Blue Care 65
  • Blue Cross Blue Shield - Indemnity
  • Blue Cross Blue Shield - Managed Care
  • Blue Cross Blue Shield - Partners Plus
  • Centene/Celticare
  • Cigna (PAL #'s)
  • Fallon Community HealthCare
  • Great-West Healthcare (formally One Health Plan)
  • Harvard Pilgrim Health Plan - ACD
  • Harvard Pilgrim Health Plan - PBO
  • Health Care Value Management (HCVM)
  • Humana/Choice Care PPO
  • Medicaid
  • Medicare
  • Medicare - ACD
  • Neighborhood Health Plan - ACD
  • Neighborhood Health Plan - PBO
  • OSW - Maine
  • OSW - New Hampshire
  • OSW - Rhode Island
  • Private Health Care Systems (PHCS)
  • Senior Whole Health
  • TriCare
  • Tufts Health Plan
  • Unicare
  • United Healthcare (non-HMO) - ACD
  • United Healthcare (non-HMO) - PBO
Patient Age Group

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Dr. Flavia Castelino is an Assistant Professor of Medicine at Harvard Medical School and a board-certified physician in the Division of Rheumatology at Massachusetts General Hospital. Dr. Castelino specializes in the treatment of scleroderma and connective tissue disease-associated lung disease.

Her research focuses on the role of lipid mediators in scleroderma fibrosis. Dr. Castelino is a member of the Early Career Investigator Subcommittee of the American College of Rheumatology and the Scleroderma Clinical Trials Consortium. She acts as a reviewer for multiple rheumatology journals including Arthritis and Rheumatology, Arthritis Care and Research and Arthritis Research and Therapy.  She is the recipient of numerous awards including the American College of Rheumatology Physician-Scientist Development Award and the Scleroderma Foundation Walter A. Coyle Memorial Research Award. Recently, she was awarded a National Institute of Health research grant to study the role of a lipid mediator, lysophosphatidic acid in scleroderma fibrosis. 

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Research & Publications


View my most recent publications at PubMed

Selected Publications:

Castelino FV, Varga J. Emerging cellular and molecular targets in fibrosis: implications for scleroderma pathogenesis and targeted therapy. Curr Opin Rheum 2014 Nov;26(6):607-14

Castelino FV, Varga J. Current Status of Systemic Sclerosis Biomarkers. Expert Rev Clin Immunol, 2013 Nov; 9 (11):1077-90.   

Castelino FV
.  Lipids and Eicosanoids in Fibrosis: Emerging Targets for Therapy.  Curr Op Rheum 2012; 24 (6): 649-655.

Castelino FV
, Goldberg H, Dellaripa PF. The Impact of Rheumatologic Evaluation in the Management of Patients with Interstitial Lung Disease. Rheumatology 2011 Mar;50(3):489-93.

Castelino FV
, Seiders J, Bain G, Brooks SF, King C, Swaney J, Lorrain D, Chun J, Luster AD, Tager AM. Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma. Arthritis and Rheumatism, 2011. May; 63(5):1405-15.

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Rheumatology Associates
55 Fruit Street
Boston MA, 02114-2696
Phone: 617-726-7938

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