The MGH Public Affairs Office works with the Department of Medicine and is responsible for the development and dissemination of MGH and Department of Medicine-related news.
A 2012 survey of internal medicine residents at Massachusetts General Hospital found that more than half rated the training they had received in addiction and other substance use disorders as fair or poor. In response to the findings the MGH has increased residents' training in addiction medicine.
05/17/2013: Mootha named an HHMI Investigator
Vamsi Mootha, MD, of the MGH Department of Medicine and the Department of Molecular Biology, is among 27 leading biomedical researchers from across the country selected as new Howard Hughes Medical Institute (HHMI) Investigators.
05/14/2013: Treatment with two osteoporosis drugs better at increasing bone density than single-drug therapy
A combination of two FDA-approved osteoporosis drugs with different mechanisms of action was found to increase bone density better than treatment with either drug alone in a small clinical trial.
Researchers from MGH and Duke University have identified genetic mutations that appear to underlie a rare but devastating syndrome combining reproductive failure with cerebellar ataxia – a lack of muscle coordination – and dementia.
MGH researchers have identified a gene variant that helps predict how much weight an individual will lose after gastric bypass surgery, a finding with the potential both to guide treatment planning and to facilitate the development of new therapeutic approaches to treating obesity and related conditions like diabetes.
A new study from investigators at the Benson-Henry Institute for Mind/Body Medicine at MGH and Beth Israel Deaconess Medical Center finds that elicitation of the relaxation response produces immediate changes in the expression of genes involved in immune function, energy metabolism and insulin secretion.
The National Quality Forum endorses the Massachusetts General Hospital’s Pediatric Symptom Checklist, a screening questionnaire used by pediatricians to improve the recognition and treatment of psychosocial problems in children.
A new system for isolating rare circulating tumor cells – living solid tumor cells found at low levels in the bloodstream – shows significant improvement over previously developed devices and does not require prior identification of tumor-specific target molecules.
Changes in the microbial population of the gastrointestinal tract may underlie some of the benefits of gastric bypass surgery, reports a team of researchers from MGH and Harvard University. The investigators also found that post-bypass alterations in the microbial population of mice can induce weight loss in animals that did not have surgery.
An analysis of data from the Framingham Offspring Study confirms that the health benefits of quitting smoking far exceed any negative effects of weight gained after smoking cessation
02/05/2013: European restrictions on working hours have 'profound' effect on medical care and education
In the February 6 issue of JAMA, investigators from MGH and Harvard Medical School describe what is known about the impact on medical care and resident training of the European Working Time Directive and its implications for postgraduate medical education in the U.S.
01/31/2013: Transition in cell type parallels treatment response, disease progression in breast cancer
A process that normally occurs in developing embryos – the changing of one basic cell type into another – has also been suspected of playing a role in cancer metastasis. Now a study from MGH Cancer Center researchers has associated this process, called epithelial-mesenchymal transition, with disease progression and treatment response in breast cancer patients.
01/25/2013: Armstrong to lead Department of Medicine
Katrina Armstrong, MD, MSCE, a world-renowned investigator in the areas of medical decision-making, quality of care and cancer prevention and outcomes, has been selected as the MGH’s next physician-in-chief of the MGH Department of Medicine.
01/14/2013: Generic HIV treatment strategy could save nearly $1 billion annually but may be less effective
Replacing the combination of brand-name, antiretroviral drugs currently recommended for control of HIV infection with soon-to-be-available generic medications could save the U.S. health care system almost $1 billion a year but may diminish the effectiveness of HIV treatment.
Investigators from MGH and the Boston Health Care for the Homeless Program compared rates and causes of death among those served by BHCHP between 2003 to 2008 with data from a 1997 study and found that, while drug overdose had replaced HIV as the leading cause of death, overall mortality rates had not changed.
01/07/2013: Looming Malpractice
The length of time it takes to resolve a malpractice claim places stress on patients, physicians and the legal system. The time spent with open claims may be even more distressing for physicians than the financial costs of the claims.
12/13/2012: Intestinal immune cells play an unexpected role in immune surveillance of the bloodstream
A type of immune cell found in the small intestine plays a previously unsuspected role in monitoring antigens circulating in the bloodstream. Disruption of the newly discovered regulatory system may lead to the development of autoimmune disorders, inflammatory bowel disease or food allergies.
Patients with terminal cancer who viewed a brief video demonstrating cardiopulmonary resuscitation (CPR) were less likely than patients who only listened to a verbal description of the procedure to indicate a preference for receiving CPR in the event of an in-hospital cardiac arrest.
Training the next generation of experts dedicated to improving the quality of the U.S. health care system will require a new framework for career development, according to three physicians writing in the January 2013 issue of Academic Medicine.
Adolph M. Hutter Jr., MD, was named the inaugural Macomber Family Endowed Scholar for Cardiovascular Performance Innovation during a Sept. 24 ceremony.
10/19/2012: Ryan appointed chief of Hematology/Oncology
On Oct. 12, the Department of Medicine and the Cancer Center announced the appointment of David Ryan, MD, as the new chief of Hematology/Oncology at the MGH. Ryan, who succeeds Jose Baselga, MD, PhD, joined the MGH Cancer Center in 1998.
Smokers today have many options to help them quit, and those who think they have "tried it all" usually have not.
10/05/2012: NEJM editor visits the MGH
To commemorate the bicentennial of the New England Journal of Medicine and the history it shares with the MGH, Editor-in-Chief Jeffrey Drazen, MD, presented “Two Hundred Years of Medical Advances” Sept. 20 at the Medical Grand Rounds in the O’Keeffe Auditorium.
Studies associating the use of popular anti-heartburn medications with an increased incidence of pneumonia may not have found a true cause-and-effect relationship. A new report also outlines a strategy for determining when the results of such observational studies may have been distorted by unmeasured factors.
09/30/2012: Phase III trial shows crizotinib superior to single-agent chemotherapy for ALK-positive lung cancer
The results of a new phase III trial show that crizotinib, a targeted therapy, is a more effective treatment than standard chemotherapy for patients with advanced, ALK-positive lung cancer.
Combined treatment with two drugs targeting different points in the same growth-factor pathway delayed the development of treatment resistance in patients with BRAF-positive metastatic malignant melanoma.
Two MGH-led research teams and one MGH investigator have received major grants from the National Institutes of Health.
The policies that several states have adopted giving tax deductions or credits to living organ donors do not appear to have increased donation rates, finds a study in the August issue of the American Journal of Transplantation.
A phase I clinical trial has confirmed that use of a generic vaccine to raise levels of an immune system modulator can cause the death of autoimmune cells targeting the insulin-secreting cells of the pancreas and temporarily restore insulin secretion in human patients with type 1 diabetes.
A program designed to encourage more healthful food choices through simple color-coded labels and the positioning of items in display cases was equally successful across all categories of employees in the MGH cafeteria.
A new study has discovered one more way that HIV exploits the immune system. Not only does the virus infect and destroy CD4 T cells – which normally direct and support the infection-fighting activities of other immune cells – the virus also appears to use those cells to travel through the body and infect other CD4 T cells.
07/23/2012: Aspirin protects against Barrett's esophagus
Aspirin use appears to reduce the risk of Barrett's esophagus, the largest known risk factor for esophageal cancer.
07/22/2012: Increased cardiovascular risk in HIV-infected patients may relate to arterial inflammation
The elevated risk of cardiovascular disease seen in patients infected with HIV appears to be associated with increased inflammation within the arteries, according to a study in a special issue of JAMA published in conjunction with the International AIDS Conference.
Researchers from the Ragon Institute of MGH, MIT and Harvard report that a mouse model with a human immune system accurately reflects the human immune response to HIV infection and has the potential to reduce significantly the time and costs required to test candidate vaccines.
07/17/2012: Massachusetts General Hospital Ranked #1 in the Nation on U.S. News & World Report Honor Roll
Massachusetts General Hospital has moved into the number one spot on the 2012-13 U.S. News & World Report’s “America’s Best Hospitals” list.
A new study finds that the use of drug-eluting stents after angioplasty bears little relationship to patients' predicted risk of restenosis (reblockage) of the treated coronary artery, the situation the devices are designed to prevent.
Detailed analysis of genes expressed in circulating tumor cells – cells that break off from solid tumors and travel through the bloodstream – has identified a potential treatment target in metastatic pancreatic cancer.
According to a new study by researchers at Brigham and Women's Hospital, MGH and Cambridge Health Alliance, certain noises in a common hospital setting can disrupt sleep and negatively affect brain activity and cardiovascular function.
The rare ability of some individuals to control HIV infection with their immune system alone appears to depend – at least partially – on specific qualities of the immune system's killer T cells and not on how many of those cells are produced.
When P. Roy Vagelos, MD, started his MGH medical residency as part of the class of 1954, he planned for a lifelong career focused on practicing medicine. However, while the residency dramatically strengthened his commitment to improving health care, it also led him down an unexpected professional path.
Palliative Care programs help with pain, symptom management and coordinating care
A new paper published online in The Lancet challenges the assumption that raising a person’s HDL — the so-called “good cholesterol” — will necessarily lower the risk of a heart attack.
04/05/2012: Big advance against cystic fibrosis
MGH researchers have taken a critical step in making possible the discovery in the relatively near future of a drug to control cystic fibrosis, a fatal lung disease that claims about 500 lives each year, with 1,000 new cases diagnosed annually.
A consortium led by researchers from the Broad Institute, Massachusetts General Hospital and six other organizations has taken a step toward addressing the genetic component of autism by searching for mutations in the fraction of the human genome that codes for proteins.
03/25/2012: Genetics of flu susceptibility
A genetic finding could help explain why influenza becomes a life-threating disease to some people while it has only mild effects in others.
A new investigational drug significantly reduced urinary cortisol levels and improved symptoms of Cushing's disease in the largest clinical study of this endocrine disorder ever conducted.
Treatment with the common diabetes drug metformin appears to prevent progression of coronary atherosclerosis in patients infected with HIV.
A subpopulation of the immune cells targeted by HIV may play an important role in controlling viral loads after initial infection, potentially helping to determine how quickly infection will progress.
Nephrologist Winfred W. Williams, MD, explains why the kidneys are important, what causes kidney disease and how to keep the kidneys healthy.
Massachusetts General Hospital research has found that insulin production may persist for decades after the onset of type 1 diabetes. Beta cell functioning also appears to be preserved in some patients years after apparent loss of pancreatic function.
02/16/2012: MGH Cancer Center team identifies potential treatment target for KRAS-mutated colon cancer
Researchers from the MGH Cancer Center have identified a new potential strategy for treating colon tumors driven by mutations in the KRAS gene, which usually resist both conventional and targeted treatments.
02/14/2012: Vitamin D treatment not found to reduce cardiovascular abnormalities in kidney disease patients
Almost a year's treatment with a vitamin D compound did not alleviate key structural and functional cardiovascular abnormalities in patients with kidney disease and cardiac enlargement.
MGH Cancer Center investigators have defined the role of a recently identified gene abnormality – rearrangements in the ROS1 gene – in non-small-cell lung cancer, the leading cause of cancer death in the U.S. They also show that these tumors can be treated with crizotinib and describe the remarkable response of one patient to such treatment.
A simple program involving color-coded food labeling and adjusting the way food items are positioned in display cases was successful in encouraging more healthful food choices in a large hospital cafeteria.
Investigators at the MGH Cancer Center have identified a new genetic signature associated with bile duct cancer, a usually deadly tumor for which effective treatment currently is limited.
Using two drugs that inhibit the growth factor HER2 for preoperative treatment of early-stage HER2-positive breast cancer appears to have better results than treatment with a single agent.
A new study finds that participating in these races actually is associated with a relatively low risk of cardiac arrest, compared to other forms of athletics. The study also identifies bystander-initiated cardiopulmonary resuscitation as a key factor in patient survival.
01/10/2012: How can pediatric HIV be eliminated in Zimbabwe?
Eliminating new infant HIV infections in Zimbabwe will require not only improved access to antiretroviral medications but also support to help HIV-infected mothers continue taking their medication and safely reduce or eliminate breastfeeding, according to study led by MGH investigators.
12/23/2011: Friendly competition brings holiday joy
The battle began brewing at the MGH in the final weeks of November.
12/19/2011: Commentary calls for greater awareness of Internet pharmacies' role in prescription drug abuse
In a commentary in the December 20 Annals of Internal Medicine, investigators from MGH, the University of Southern California, and the National Center on Addiction and Substance Abuse at Columbia University describe the probable contribution of Internet pharmacies to prescription drug abuse and outline potential strategies for addressing the problem.
Being able to define and measure patient complexity has important implications for how care is organized, how physicians and health care systems are paid, and how resources are allocated. A study by MGH researchers finds that primary care physicians define patient complexity using more factors than are used in common approaches.
An international clinical trial has found that treatment with a drug that suppresses the normal breakdown of bone can delay the development of bone metastases in men with prostate cancer.
11/10/2011: From Protestation to Presentation
Changing the understanding of Palliative Care, a patient's story
A new device that combines two microimaging technologies can reveal both the detailed anatomy of arterial linings and biological activities that, in coronary arteries, could indicate the risk of heart attacks or the formation of clots in arterial stents.
10/21/2011: ‘Looking back and thinking forward’
As a slideshow of black and white images from the past turned into color photographs from the present, George Thibault, MD, president of the Josiah Macy Jr. Foundation and former chief resident and program director in the Department of Medicine, took to the podium to welcome many of the staff featured in the photos.
Adding regular testing for blood levels of a biomarker of cardiac distress to standard care for the most common form of heart failure may significantly reduce the incidence of cardiovascular complications, a new MGH study finds.
Long-term administration of the dietary supplement saw palmetto, even at three times the usual dose, did not reduce symptoms of prostate enlargement significantly better than placebo in a large group of middle-aged men.
A new report from MGH scientists and colleagues around the world finds that common variants in 28 regions of DNA are associated with blood pressure in human patients. Most of the identified regions were completely unsuspected, and several may lead to a totally new class of hypertension drugs.
While most U.S. physicians will face a malpractice lawsuit at some time in their careers, a new study finds, the vast majority of those suits will not result in payment to a plaintiff. The report provides the most comprehensive analysis of the risk of malpractice claims by specialty in more than two decades.
A new study shows for the first time that natural killer cells, which are part of the body's first-line defence against infection, can contribute to the immune response against HIV. The findings may help develop new preventive or treatment strategies.
A novel therapy that reduces elevated blood levels of a potentially toxic protein in women with preeclampsia, a dangerous complication of pregnancy, may someday address the therapeutic dilemma posed by the condition – balancing life-threatening risks to the mother with the dangers that early delivery poses to an immature fetus.
07/19/2011: MGH ranks #2 in nation
MGH ranks #2 in 2011-2012 U.S. News & World Report "Best Hospitals" rankings
07/15/2011: Breaking down barriers
In academia, it’s a remarkable achievement for any physician to be promoted to full professor.
06/24/2011: In General 06.24.11
In General awards and honors
New research finds that gestational diabetes, or pregnancy-related diabetes, may not raise the risk of heart disease independent of other cardiovascular risk factors except in certain high-risk populations.
05/22/2011: The Dance of the Cells: A Minuet or a Mosh?
The physical forces that guide how cells manage to get from place to place inside the living body are poorly understood. Now scientists have for the first time devised a way to measure these forces during collective cellular migration.
New research shows that PCR testing for Borrelia burgdorferi DNA—the spirochetal bacteria transmitted by deer ticks—in joint fluid may confirm the diagnosis of Lyme arthritis, but is not a reliable indicator for active joint infection in patients whose arthritis persists.
Increasing access to rogue online pharmacies that dispense medications without a doctor's prescription may be an important factor behind the rapid increase in the abuse of prescription drugs.
04/22/2011: Celebrating prize-winning MGH research
The presentation of the MGH's top research prizes was a highlight of the April 13 Celebration of Science, held in conjunction with the annual Scientific Advisory Committee meeting.
04/22/2011: SAC meeting
The 64th meeting of the MGH Scientific Advisory Committee (SAC) on April 14 celebrated key accomplishments of MGH investigators, past and present, and examined strategies for meeting the challenges currently facing the academic biomedical research community.
ALL MGHERS are invited to attend the 2011 meeting of the MGH Scientific Advisory Committee (SAC), which will commemorate the hospital’s bicentennial with a look back at significant research accomplishments of MGH investigators and examine challenges facing today’s research community.
A detailed analysis of lung tumors that became resistant to targeted therapy drugs has revealed two previously unreported resistance mechanisms. The report also describes how the cellular nature of some tumors can change in response to treatment and finds how resistance-conferring mutations can disappear after treatment is discontinued.
Measuring the levels of small molecules in the blood may be able to identify individuals at elevated risk of developing type 2 diabetes as much as a decade before symptoms of the disorder appear.
A new mathematical model of the Haitian cholera epidemic, based on current knowledge about the transmission and course of the disease, finds that current projections regarding the size and extent of the epidemic may greatly underestimate the eventual number of cases.
Elevated levels of p21, a protein best known as a cancer fighter, may be involved in the ability of a few individuals to control HIV infection with their immune system alone.
03/09/2011: Aspirin's ability to protect against colorectal cancer may depend on risk-associated inflammatory pathways
The reduced risk of colorectal cancer associated with taking aspirin or other nonsteroidal anti-inflammatory drugs may be limited to individuals already at risk because of elevations in a specific inflammatory factor in the blood.
An international research collaboration has identified 13 new gene sites associated with the risk of coronary artery disease and validated 10 sites found in previous studies. Several of the novel sites discovered do not appear to relate to known risk factors, suggesting previously unsuspected mechanisms for cardiovascular disease.
Homeless people who do not get enough to eat use hospitals and emergency rooms at very high rates, according to a new study from MGH and Boston Health Care for the Homeless.
01/28/2011: Helping hands in India
MGH Hotline 1.28.11 When Stephanie Moore, md, a cardiologist with the MGH Heart Center, made her first trip to the city of Kolkata, India, in May 2009, she witnessed the extreme poverty experienced by many of the city's sick and poor.
01/21/2011: Gardner serves in Haiti as Durant fellow
MGH Hotline 1.21.11 “You are not able to change the whole world, but you are able to give hope to one human being,” are words attributed to Albert Schweitzer, MD, PhD, a 1952 Nobel Peace Prize recipient and the inspiration for the creation of Hôpital Albert Schweitzer in Deschapelles, Haiti.
MGH Cancer Center researchers have discovered a previously unknown feature of common tumor cells – massive overexpression of satellite repeats, which are DNA sequences that do not code for proteins. The findings may improve understanding of tumor development and provide a new cancer biomarker.
MGH Hotline 12.10.10 A named chair is one of the highest honors a physician may receive in his or her lifetime.
A team of researchers has determined that the strain of cholera erupting in Haiti matches bacterial samples from South Asia and not those from Latin America. The scientists conclude that the bacteria introduced into Haiti most likely came from an infected human, contaminated food or other item from outside of Latin America.
12/03/2010: Showcasing primary care
MGH Hotline 12.3.10
A new study finds that an FDA-approved drug to treat the rare autoimmune disorder immune thromobocytopenia (ITP) is more effective than earlier medical therapies in helping patients avoid surgical treatment and significantly improving their quality of life.
Tiny variants in a protein that alerts the immune system to the presence of infection may underlie the rare ability of some individuals to control HIV infection without the need for medications.
A clinical trial of a potential new targeted treatment drug has provided powerful evidence that it can halt or reverse the growth of lung tumors characterized by alterations in the anaplastic lymphoma kinase (ALK) gene.
An enzyme that keeps intestinal bacteria out of the bloodstream may also play an important role in maintaining the normal microbial population of the gastrointestinal system.
MGH Hotline 10.15.10 As scientists have increased access to human genetic information, the interpretation of this information as it relates to human disease and clinical decision-making becomes more feasible.
An international consortium has made significant inroads into uncovering the genetic basis of obesity by identifying 18 new gene sites associated with overall obesity and 13 that affect fat distribution. The studies include data from nearly a quarter of a million participants, the largest genetic investigation of human traits to date.
The well-documented disparities in cardiac care may begin almost as soon as patients arrive at hospital emergency rooms, Mass. General investigators find.
Researchers report that three out of five resident physicians responding to a survey came to work in the previous year while sick, possibly exposing their patients and colleagues to suboptimal performance and, in many cases, communicable disease.
Evaluating the quality of care delivered by individual physicians without accounting for such factors as their patients' socioeconomic status or insurance coverage risks undervaluing the work of those caring for a higher proportion of vulnerable patients.
08/25/2010: Targeted drug leads to rapid regression of metastatic melanoma in patients with mutated BRAF gene
Use of an experimental targeted drug to treat metastatic melanoma tumors with a specific genetic signature was successful in more than 80 percent of patients in a phase 1 clinical trial.
08/04/2010: MicroRNA molecule increases number of blood stem cells, may help improve cancer treatment
MGH investigators have identified a new mechanism that controls the number of the stem cells that give rise to all blood and immune system cells, an advance that may improve treatment of blood system cancers.
08/04/2010: Sorting out the genetic and biological links between cholesterol and coronary heart disease
Two papers in the current issue of Nature describe 95 gene variations that contribute to cholesterol and triglyceride levels and reveal the unexpected role of a metabolic pathway in lipid metabolism.
Clinical trials from two international research teams have shown that icatibant, a new drug that blocks the action of an inflammatory protein known as bradykinin, is safe and effective in treating acute attacks of hereditary angioedema, a potentially life-threatening condition.
SPAIN MAY HAVE WON the World Cup, but a team of MGH medical residents and fellows had a victory of their own on the soccer field this summer when they helped save the life of another player.
Investigators have made a major advance in treating people with a rare but devastating disease of blood vessels.
07/09/2010: Universal HIV testing and immediate treatment could reduce but not eliminate HIV/AIDS epidemic
Implementing universal HIV testing and immediate antiretroviral treatment for infected individuals could have a major impact on the HIV/AIDS epidemic in Washington, DC but not halt the epidemic, which a previous report had projected.
An analysis of insurance records of more than 1.4 million U.S. men over 40 found that those who used ED drugs were more likely to have sexually transmitted diseases than were non-users.
An international research consortium has identified four common gene variants that are associated with blood levels of vitamin D and with an increased risk of vitamin D deficiency.
Heart attacks declined by 24 percent within a large, ethnically diverse, community-based population since 2000, and the relative incidence of serious heart attacks that do permanent damage declined by 62 percent, according to a study in the current issue of the New England Journal of Medicine.
Using a system that analyzes blood samples with unprecedented detail, a team led by MGH researchers has developed the first "chemical snapshot" of the metabolic effects of exercise.
The vast majority of homeless adults surveyed in a national study had trouble accessing at least one type of needed health care service in the preceding year, according to what may be the first broad-based national study of factors related to unmet health needs among homeless people.
Long-term anabolic steroid use may weaken the heart more than previously thought and may increase the risk of heart failure, according to a study led by MGH investigator Aaron Baggish, MD.
An artificial pancreas system that closely mimics the body's blood sugar control mechanism was able to maintain near-normal glucose levels without causing hypoglycemia in a small group of patients.
03/16/2010: Increased radiation dose does not increase long-term side effects for prostate cancer patients
Boosting the radiation dose given to prostate cancer patients to a level that cut recurrence in half did not increase the severity of side effects reported by patients up to a decade later. Patients also found the impact of continuing side effects on their quality of life to be less bothersome than would be expected, based on earlier studies.
A new study by researchers at the MGH Heart Center found the addition of electrocardiogram testing to the standard medical history and physical examination for young athletes may better identify key cardiovascular abnormalities responsible for sports-related sudden death.
According to a new study accepted for publication in the Journal of Clinical Endocrinology & Metabolism, obese teenage girls with a greater ratio of visceral fat (fat around internal organs) to subcutaneous fat (fat found just beneath the skin) are likely to have lower bone density than peers with a lower ratio of visceral to subcutaneous fat.
An international research team has identified a common gene variant associated with a form of the irregular heartbeat called atrial fibrillation that is seen in younger individuals with no other heart disease.
Surgery provides better results than nonsurgical treatment for most patients with back pain related to a herniated disk - but not for those receiving workers' compensation for work-related injuries, according to a study in the journal Spine.
A major international study with leadership from MGH researchers has identified 10 new gene variants associated with blood sugar or insulin levels. Two of these novel variants and three that earlier studies associated with glucose levels were also found to increase the risk of type 2 diabetes.
01/08/2010: Addressing the fight against HIV/AIDS in Africa
MGH Hotline 01.08.10 The MGH Division of Global Health and Human Rights, the Departments of Medicine and Emergency Medicine, and MassGeneral Hospital for Children welcomed journalist, scientist and public health consultant Helen Epstein, PhD, for a Dec. 10 discussion of her experience studying the proliferation of HIV/AIDS on the African continent.
A Massachusetts General Hospital study has found that relatively young men with longstanding HIV infection and minimal cardiac risk factors had significantly more coronary atherosclerotic plaques - some involving serious arterial blockage - than did uninfected men with similar cardiovascular risk.
12/18/2009: Cervical Cancer Screening
The American College of Obstetricians and Gynecologists (ACOG) recently released new guidelines for cervical cancer screening. Dr. Marcela Del Carmen from the Obstetrics and Gynecology Service and Dr. Elizabeth Roth from the Women’s Health Associates at Mass General help put this in context.
Patients with terminal brain cancer who watched a brief video illustrating options for end-of-life care were significantly more likely to indicate a preference for comfort measures only than were patients who listened to a verbal description of treatment choices.
11/06/2009: In memoriam: Paul C. Zamecnik, MD
MGH Hotline 11.06.09 PAUL C. ZAMECNIK, MD, a renowned senior scientist in the Department of Medicine, died Oct. 27 at his home in Boston. He was 96.
Massachusetts General Hospital partnered with the American Heart Association during the 2009 Boston Heart Walk, an event that raises funds to support lifesaving heart and stroke research.
A team of researchers led by Massachusetts General Hospital radiologists has developed a computed-tomography-based protocol that identifies both narrowing of coronary arteries and areas of myocardial ischemia - restricted blood flow to heart muscle tissue - giving a better indication of clinically significant coronary artery disease.
Levels of a biomarker used in the diagnosis of heart attacks are almost universally elevated in patients who have undergone coronary-artery bypass grafting (CABG) and, when markedly elevated, powerfully predict the risk of complications.
09/01/2009: New assessment quantifies risks and benefits of warfarin treatment for atrial fibrillation
Warfarin therapy for patients with atrial fibrillation - the most common type of significant heart rhythm disorder - appears to be most beneficial for the oldest patients, those who have had a prior stroke and for patients with multiple risk factors for stroke.
08/31/2009: Renal Associates Practice Moving - New Address
The Renal Associates practice is moving to allow for continued growth in an area that is just one-half mile from our current location.
08/21/2009: O'Connell named J.H. Kanter Prize Laureate
MGH Hotline 08.21.09 James J. O'Connell, MD, of the MGH Department of Medicine, is known throughout Boston as a physician with a heart for the homeless.
Twice-yearly treatment with denosumab, a new targeted therapy to stop bone loss, increased bone density and prevented spinal fractures in men receiving androgen-deprivation therapy for prostate cancer.
Regular use of aspirin after colorectal cancer diagnosis may reduce the risk of cancer death, report investigators from Massachusetts General Hospital, Dana-Farber Cancer Institute and Brigham and Women’s Hospital.
07/31/2009: Thinking outside the box
MGH Hotline 07.31.09 Who would think a simple plastic tube and a set of car parts could help save the lives of newborns around the world? For Kristian Olson, MD, MPH, of the MGH Department of Medicine and the Center for the Integration of Medicine and Innovative Technology (CIMIT) Global Health Initiative, this type of out-of-the-box thinking is nothing new.
Near-normal control of glucose beginning as soon as possible after diagnosis would greatly improve the long-term prognosis of type 1 diabetes, concludes a study published in the July 27, 2009, issue of the Archives of Internal Medicine, which updates information about the clinical course of type 1 diabetes.
MGH Hotline 07.24.09 In eight-minute intervals, 45 participants each greet one another, discuss their accomplishments, challenges and goals, and then move on to the next person to do the same. Although the scenario sounds like "speed dating," it actually describes the Department of Medicine’s Women in Medicine Speed Networking Event for residents, fellows and faculty.
07/22/2009: Mass. General-based research center will investigate why immune system fails to control hepatitis C
A research consortium based at Massachusetts General Hospital has been awarded $15 million from the National Institute of Allergy and Infectious Diseases to investigate how the hepatitis C virus resists suppression and clearance by the immune system.
07/20/2009: Study suggests earlier HIV antiviral treatment saves lives and is cost effective, even in areas of limited resources
Early initiation of lifesaving antiretroviral therapies should be the standard of care for all HIV-infected patients, even those in countries with limited medical and financial resources, according to a study led by researchers at MGH and the Desmond Tutu HIV Centre, University of Cape Town, South Africa.
07/16/2009: Monitoring patients remotely
New wireless technology allows Heart Center clinicians to keep tabs on heart failure patients wherever they are
07/13/2009: Differences in immune response may explain why HIV-1 disease progresses faster in women than in men with same viral load
A research team based at the Ragon Institute of MGH, MIT and Harvard has found a gender-based difference in the response of a first-line immune cell to HIV that may explain why the infection usually progresses faster in women than in men with the same viral loads.
Measurement of known biomarkers of cardiovascular disease slightly improves the ability to predict future heart attack or stroke in healthy individuals, but not enough to change preventive therapies.
A common electrocardiogram finding that has largely been considered insignificant may actually signal an increased risk of atrial fibrillation, the future need for a permanent pacemaker and an increased risk for premature death.
Viewing a video showing a patient with advanced dementia interacting with family and caregivers may help elderly patients plan for end-of-life care, according to a study led by MGH researchers.
New estimates of the likelihood that a latent case of tuberculosis will become active have resulted in a roughly 50 percent increase over previous estimates of the number of people needed to be screened to prevent an active infection.
Someday, even doctor visits could be among the conveniences offered via the Internet. In a comparison of desktop videoconferencing to conventional face-to-face general medical evaluations, patients found virtual visits similar to face-to-face visits on most measures. This study suggests that both patients and physicians could benefit if virtual visits were used as an alternative method of accessing primary care services.
Scientists from Massachusetts General Hospital (MGH), as part of a major international research collaboration, have associated common variants in eight regions of DNA with blood pressure levels in human patients. Six of the identified regions have not previously been implicated in blood pressure regulation.
04/10/2009: In General
MGH Hotline 4.10.09 In General awards and honors
Results of the study from a collaborative team led by researchers at Massachusetts General Hospital and the International Centre for Diarrhoeal Disease Research, Bangladesh suggest that parasitic infection could reduce the immune response to cholera, which may compromise the effectiveness of cholera vaccines.
Graduates of the Program in Clinical Effectiveness, which has trained almost 1,900 physicians to be clinical investigators since 1986, have achieved significant success in receiving grant support from the National Institutes of Health and other funders, along with other accomplishments considered key to establishing a research career.
A new study has identified several common genetic variants related to a risk factor for sudden cardiac death. The report receiving early online release in the journal Nature Genetics identifies variants in genes, some known and some newly discovered, that influence the QT interval measured on the electrocardiogram (EKG) performed routinely in doctors’ offices.
The Department of Health and Human Services today announced the selection of David Blumenthal, M.D., M.P.P. as the Obama Administration’s choice for National Coordinator for Health Information Technology.
A groundbreaking partnership between the Howard Hughes Medical Institute and the University of KwaZulu-Natal in South Africa will establish an international research center focused on the worldwide effort to control the devastating co-epidemic of tuberculosis and HIV.
Massachusetts General Hospital (MGH) researchers are investigating a new way to block reproduction of the hepatitis C virus – targeting not the virus itself but the human genes the virus exploits in its life cycle.
A new study finds that patients who are connected to a specific primary care physician are more likely to receive guideline-consistent care than those who are connected to a practice but not a physician.
02/27/2009: MGH Durant fellows
MGH Hotline 2.27.09 As a true humanitarian, Thomas S. Durant, MD, spent his life bringing hope to some of the bleakest parts of the world. In honor of his service and compassion, the MGH Durant Fellowship in Refugee Medicine helps health care professionals bring their skills to those in critical need around the globe.
A new study has identified the first common gene variants associated with an increased incidence of hypertension – a significant risk factor for heart attack, stroke and kidney failure.
The largest study ever completed of genetic factors associated with heart attacks has identified nine genetic regions - three not previously described - that appear to increase the risk for early-onset myocardial infarction.
02/06/2009: Course in community-oriented primary care
For the first time at the MGH, the Departments of Medicine and Pediatrics have come together with the MGH Combined Medicine/Pediatrics Residency Program
MGH Hotline 1.19.09 Marcus Altfeld, MD, PhD, associate professor of Medicine and director of the Innate Inmunity Program at the Partners AIDS Research Center, is one of six recipients of the Doris Duke Distinguished Clinical Scholar Award from the Doris Duke Charitable Foundation.
Researchers from Massachusetts General Hospital have found that tissues from mice transgenic for a gene usually found in the c.elegans roundworm contain omega-3 fatty acids, consumption of which has been shown to protect against heart disease.
04/01/2009: Senior HealthWISE Newsletter
View this publicaton
Community wellness, involvement, support adn education
03/01/2009: Senior HealthWISE Newsletter
View this publication
Community wellness, involvement, support and education
02/01/2009: Senior HealthWISE Newsletter
View this publication
Community wellness, involvement, support and education
01/01/2009: Senior HealthWISE Newsletter
Senior HealthWISE January 2009 Newsletter
Community wellness, involvement, support and education
11/01/2008: MGH Senior Healthwise Newsletter
View this publication
Community wellness, involvement, support and education.
11/01/2008: Neuroendocrine Clinical Center Bulletin
Volume 14, Issue 2, Fall 208
The Neuroendocrine Clinical Center Bulletin is a bi-annual publication that covers important trends in research and treatment of neuroendocrine conditions and disease.
01/01/2006: Neuroendocrine Clinical Center Bulletin
Neuroendocrine Clinical Center Bulletin | Effect of Obesity on Growth Hormone Secretion
The Mass General Neuroendocrine Clinical Center Bulletin shares the latest information for health care professionals about clinical and research topics in neuroendocrine conditions.
The Paul S. Russell, MD Museum of Medical History and Innovation Lecture Series Presents "The Morphing of MGH: Architecture Reflects Changing Patterns of Care"
09/28/2010: Brain Aneurysm Symposium
Our Vascular Center clinicians invite you to join us for a Brain Aneurysm Symposium, sponsored by Massachusetts General Hospital and the Brain Aneurysm Foundation. Learn who is at risk for developing brain aneurysms, and about treatment options and ongoing research to help patients with this difficult condition.
04/23/2010: Stoeckle Center Seminar
"Medication Safety and Transitions in Care: The Role of the PCP"
03/10/2010: Cardiology Grand Rounds
Massachusetts General Hospital Cardiology Grand Rounds take place on Wednesdays from 8:00 am to 9:00 am in the O’Keeffe Auditorium of the Blake Building. This week's Cardiology Grand Rounds speaker is Ahmed Tawakol, MD, and the topic is, "PET studies of Atherosclerosis and Inflammation."
03/03/2010: Cardiology Grand Rounds
Massachusetts General Hospital Cardiology Grand Rounds take place on Wednesdays from 8:00 am to 9:00 am in the O’Keeffe Auditorium of the Blake Building. This week's Cardiology Grand Rounds speaker is Michael S. Lauer, MD, FACC, FAHA, and the topic is, "Government Support of Comparative Effectiveness Research: One Year Later"
02/24/2010: Cardiology Grand Rounds
Massachusetts General Hospital Cardiology Grand Rounds take place on Wednesdays from 8:00 am to 9:00 am in the O’Keeffe Auditorium of the Blake Building. This week's Cardiology Grand Rounds speaker is Joseph E. Parrillo, MD, and the topic is, "Reversible Causes of Myocardial Depression: Sepsis, Ischemia, and Myocarditis."
02/17/2010: Cardiology Grand Rounds
Massachusetts General Hospital Cardiology Grand Rounds take place on Wednesdays from 8:00 am to 9:00 am in the O’Keeffe Auditorium of the Blake Building. This week's Cardiology Grand Rounds speaker is Peter Ganz, MD, and the topic is, "25 Years of Endothelial Research in Humans: Where We Have Been and Where We Are Going."
02/10/2010: Cardiology Grand Rounds
Massachusetts General Hospital Cardiology Grand Rounds take place on Wednesdays from 8:00 am to 9:00 am in the O’Keeffe Auditorium of the Blake Building. This week's Cardiology Grand Rounds speaker is Aaron Baggish, MD, and the topic is, "Exercise-Induced Cardiac Remodeling: From Bedside to Bench."
02/03/2010: Cardiology Grand Rounds
Massachusetts General Hospital Cardiology Grand Rounds take place on Wednesdays from 8:00 am to 9:00 am in the O’Keeffe Auditorium of the Blake Building. This week's Cardiology Grand Rounds speaker is Mark Creager, MD, and the topic is, “Peripheral Atherosclerotic Vascular Disease: Implications for the Cardiologist.”
01/27/2010: Cardiology Grand Rounds
Massachusetts General Hospital Cardiology Grand Rounds take place on Wednesdays from 8:00 am to 9:00 am in the O’Keeffe Auditorium of the Blake Building. This week's Cardiology Grand Rounds speaker is Valentin Fuster, MD, and the topic is to be announced.
01/20/2010: Cardiology Grand Rounds
Massachusetts General Hospital Cardiology Grand Rounds take place on Wednesdays from 8:00 am to 9:00 am in the O’Keeffe Auditorium of the Blake Building. This week's Cardiology Grand Rounds speaker is Saumya Das, MD, PhD, and the topic is, "Heart Failure and Ventricular Arrhythmias: Revisiting the Sodium Channel."
01/13/2010: Cardiology Grand Rounds
Massachusetts General Hospital Cardiology Grand Rounds take place on Wednesdays from 8:00 am to 9:00 am in the O’Keeffe Auditorium of the Blake Building. This week's Cardiology Grand Rounds speaker is Zoltan Arany, MD, PhD, and the topic is, "At the Intersection of Metabolism and Angiogenesis: New Lessons for Making Blood Vessels?"
01/06/2010: Cardiology Grand Rounds
Massachusetts General Hospital Cardiology Grand Rounds take place on Wednesdays from 8:00 am to 9:00 am in the O’Keeffe Auditorium of the Blake Building. This week's Cardiology Grand Rounds speaker is Jonathan R. Lindner, MD, and the topic is, "Molecular Imaging of Cardiovascular Phenotype: New Diagnostic Paradigms on the Horizon."
10/28/2009: Cardiology Grand Rounds
Massachusetts General Hospital Cardiology Grand Rounds take place on Wednesdays from 8:00 am to 9:00 am in the O’Keeffe Auditorium of the Blake Building. This week's Cardiology Grand Rounds speaker is Rodney Falk, MD, and the topic is, "Marching to a different rhythm: conundrums in the diagnosis and management of cardiac amyloidosis."
10/21/2009: Cardiology Grand Rounds
Massachusetts General Hospital Cardiology Grand Rounds take place on Wednesdays from 8:00 am to 9:00 am in the O’Keeffe Auditorium of the Blake Building. This week's Cardiology Grand Rounds speaker is Catherine M. Otto, MD, and the topic is, "Calcific aortic stenosis: new concepts in disease pathophysiology."
10/15/2009: On-Demand CME Program
Confronting the Epidemic of Esophageal Cancer: Innovative Screening Techniques and Treatment Strategies for Barrett's Esophagus and GERD
10/14/2009: Cardiology Grand Rounds
Massachusetts General Hospital Cardiology Grand Rounds take place on Wednesdays from 8:00 am to 9:00 am in the O’Keeffe Auditorium of the Blake Building. This week's Cardiology Grand Rounds speaker is Henry Gewirtz, MD, and the topic is an update on quantitative PET for Dx for CAD extent and location.
The third annual conference dedicated to the care of vascular patients
10/07/2009: Cardiology Grand Rounds
Massachusetts General Hospital Cardiology Grand Rounds take place on Wednesdays from 8:00 am to 9:00 am in the O’Keeffe Auditorium of the Blake Building. This week's Cardiology Grand Rounds speaker is Kenneth L. Baughman, MD, and the topic is about peripartum cardiomyopathy.
10/05/2009: Heart Disease in Women - 2009 Update
Heart Disease in Women 2009 Update brings together experts in women's heart health to discuss how to best diagnose and treat this population.
09/30/2009: Cardiology Grand Rounds
Massachusetts General Hospital Cardiology Grand Rounds take place on Wednesdays from 8:00 am to 9:00 am in the O’Keeffe Auditorium of the Blake Building. This week's Cardiology Grand Rounds speaker is Mihai Gheorghiade, MD, and the topic is about acute heart failure syndromes.
03/25/2009: Schwartz Center Rounds
The Insatiable Mistress
Medical Grand Rounds
01/21/2009: Schwartz Center Rounds
Schwartz Center Rounds are unique, multi-disciplinary sessions in which hospital staff explore the emotional side of caregiving.
Deborah Hines, NP, encourages talking with your doctor about peripheral artery disease, a circulatory condition in which arteries narrowed by atherosclerosis reduce blood flow to the limbs, particularly to the legs and arms.
Michael Jaff, DO, encourages the public to recognize the symptoms of peripheral artery disease, a circulatory condition in which arteries narrowed by atherosclerosis reduce blood flow to the limbs, particularly to the legs and arms.
March 4, 2009 Palliative Care grand rounds presentation by Todd Rinehart LICSW, MGH Palliative Care Service.
Jan. 28, 2009 Palliative Care grand rounds presentation by Anne Grinyer, PhD.
Dec. 3, 2008 Palliative Care grand rounds presentation by Nancy Keating MD, MWH General Medicine and Primary Care.
Feb. 18, 2009 Palliative Care grand rounds presentation by Nathan Cherny MBBS FRACP FRCP, Ben Gurion University, Jerusalem, Israel.
April 15, 2009, Palliative Care Grand rounds presentation by Lindy Landzaat, DO, Palliative Care Fellow, MGH/DFCI, Boston, MA
September 30, 2009 Grand Rounds presentation by Arthur M. Kleinman, MD HMS Dept of Social Medicine
October 7 2009 Grand Rounds presentation by Zara Cooper, MD Brigham & Women’s Hospital Surgery Dept.
October 14 2009 Palliative Care Grand Rounds presented by John Halporn, MD, Partners Community Healthcare, Inc
November 4 2009 Palliative Care Grand Rounds presented by David Lee, MD Lamb Pain Foundation
January 6th Grand Rounds presentation by Laurie Rosenblatt, MD, Beth Isreal Deaconess Medical Center, Boston, MA
February 3rd 2010, Grand Rounds presented by Julie M. Hauer, MD, Dana Farber Cancer Institute
The End-of-Life Experience of Children Undergoing Hematopoietic Stem Cell Transplant: Parent and Provider Perspecrives and Patterns of Care
February 10, 2010 Grand Rounds presented by Christina K. Ullrich, MD, MPH-Pediatrics, DFCI/Children’s
February 17, 2010 Paul Currier, MD, MGH, Pulmonary and Critical Care Unit
February 24, 2009 Grand Rounds presented by Jennifer Temel, MD, Hematology/Oncology, MGH
March 10, 2010 Grand Rounds presented by Teresa A. Gilewski, MD, Memorial Sloan-Kettering Cancer Center, NY
March 31, 2010 Grand Rounds presented by Patricia O’Malley, MD, MGH - Director, Pediatric Palliative Care, Boston
April 7, 2010 Grand Rounds presented by Holly Prigerson, PhD, Department of Psychosocial Oncology and Palliative Care, Dana Farber Cancer Institute, Boston
April 14, 2010 Palliative Care Grand Rounds presented by James Willett, MD, MBE, MGH/DFCI, Palliative Care, Boston
May 5 2010 Grand Rounds presented by Heidi Blake, MD, Fellow, MGH/DFCI Palliative Care
May 12, 2010 Grand Rounds presented by Randall H. Paulsen, MD, Psychiatry, Harvard Medical School, Brigham and Women's Hospital, Boston Psychoanalytic Society and Institute
May 19, 2010 Grand Rounds presented by Jamie Potosek, MD, Fellow, MGH/DFCI Palliative Care
May 26, 2010 Grand Rounds presented by Andrea Dimond, MD, Fellow, MGH/DFCI Palliative Care
June 2, 2010 Grand Rounds presented by Eve Block, MD, Fellow, MGH/DFCI Palliative Care
June 9 2010 Grand Rounds presented by Andrea Phelps, MD, Fellow, MGH/DFCI Palliative Care, Boston
Vijay Yajnik, MD, gastroenterologist at the Massachusetts General Hospital Digestive Healthcare Center, explains why inflammatory bowel disease often goes untreated and the promising new therapies that can minimize IBD's impact on daily life.
Malissa Wood, MD, Co-Director of the Corrigan Women's Heart Health Program at the Massachusetts General Hospital Heart Center describes the heart attack symptoms that are unique to women, and why treatment of heart disease should be gender-specific.
Sekar Kathiresan, MD, explains what you can do to lower your risk of developing coronary artery disease
Sekar Kathiresan, MD, Director of Preventive Cardiology at the Massachusetts General Hospital Heart Center says counteracting your genetic risk is within your control. Learn more about coronary artery disease, who is most at risk and about Mass General's Heart Attack Prevention Program, focused on people with a family history of the disease.
Aaron Baggish, MD, Associate Director for the Cardiovascular Performance Program at the Massachusetts General Hospital Heart Center explains how heart problems are diagnosed in highly active people and how Mass General specialists help them exercise safely to reduce the risk of heart attack.
Guy Rordorf, MD, vascular neurologist at the Massachusetts General Hospital Vascular Center, says an imaging test can detect fibromuscular dysplasia (FMD), and recommends it for those with a family history of the condition. Learn more about FMD and how it weakens artery walls and can lead to severe hypertension or stroke.
Stephanie Moore, MD, describes your risk for heart failure if you have a family history of this condition
Stephanie Moore, MD, cardiologist in the Heart Failure and Cardiac Transplant Program at the Mass General Heart Center says if a close relative suffered from heart failure, you should be screened for other health issues that can put you at higher risk. Learn more about the early signs of heart failure and the various treatments available, from medications to pacemakers to transplants.
Alice Shaw, MD, thoracic oncologist at the Mass General Cancer Center, says patients with lung cancer can benefit from genetic testing, particularly if they are young non-smokers. Learn more about personalized treatment for lung cancer and new "smart drugs" that target a tumor's specific genetic mutation to slow the cancer's growth, and in some cases, reduce it significantly.
Dr. Patrick Ellinor, cardiologist at the Mass General Heart Center, says you should discuss your condition with your doctor
Dr. Patrick Ellinor, cardiologist at the Mass General Heart Center, says you should discuss your condition with your doctor, since many people who could benefit from specific treatments are not aware of them.