In addition to leading the way in clinical care, the Department of Medicine plays an instrumental role in advancing biomedical research and developing new therapies for disease. One of the top departmental recipients of funding from the National Institutes of Health, our thriving research enterprise hosts an extremely diverse portfolio of investigation in basic science and clinical research.
Brack Lab
Our lab interests lie at the interface between adult stem cell biology and tissue regeneration. We focus on the molecular pathways that control cell fate decisions of the adult muscle stem cell (the satellite cell) to effectively regenerate adult skeletal muscle.
Cost Effectiveness of Preventing AIDS Complications (CEPAC)
Cost Effectiveness of Preventing AIDS Complications (CEPAC) is an HIV clinical modeling team that compares the effectiveness of different HIV treatment strategies, in collaboration with investigators around the world.
Cowan Lab
Our research is focused on understanding the contribution of environmental and genetic factors in the development of disease. We are building in vitro models using human embryonic stem cells, in which genetic and developmental aspects of the disease can be controlled.
Davidson Lab
Our lab uses zebrafish as a genetic model system to understand how kidney cells are formed during embryonic development. We are currently using genetic screens, morpholino-mediated gene knockdown, and the generation of inducible transgenic lines to unravel the transcriptional networks governing renal development.
Diabetes Research Center
The MGH Diabetes Clinical Research Center, currently in its 20th year, focuses on the development and evaluation of innovative therapies for Type 1 and Type 2 diabetes and their complications.
Diabetes Research Center - Clinical and Translational Research
For over two decades, the Mass General Diabetes Clinical Research Center has developed and evaluated innovative therapies for Type 1 and Type 2 diabetes.
Endocrine Unit: Wu Laboratory
The Wu laboratory uses genetic mouse models to study the differentiation of bone-forming osteoblasts from mesenchymal progenitors, and the role of osteoblasts in supporting hematopoietic development.
Geijsen Lab
My laboratory focuses on understanding the biology of pluripotent stem cells. We aim to develop novel human models for development and disease, to ultimately enable the application of cell- or tissue-based therapies for the treatment of degenerative disease.
GI Cancers – Daniel C. Chung Laboratory
Our laboratory seeks to gain new insights into the molecular pathogenesis of tumors of the GI tract. Our particular areas of interest are colon cancer, neuroendocrine tumors, angiogenesis, hypoxia, hereditary cancers, and genetic instability. We seek to identify molecular targets that can ultimately guide therapeutic strategies.
hESC Core Facility
The purpose of the human embryonic stem cell (hESC) Core Facility is to provide an institutional resource for hESC research at Massachusetts General Hospital.
Hochedlinger Lab
Our lab tries to understand the role stem cells play in normal development and disease.
Hock Lab
Our laboratory is interested in the transcriptional regulation of normal blood cell development and leukemia.
HSCI-CRM Flow Cytometry Core Facility
Offers custom-built instrumentation for cell sorting and data analysis.
Intestinal epithelial cell homeostasis – Mizoguchi Lab
Our Main Research Interests: Intestinal epithelial cell homeostasis under normal and inflammatory conditions; Role of epithelial cells in innate and acquired immune response; Cellular and molecular biology of mucosal immunity.
Laboratory for Lipid Medicine and Technology
The Laboratory for Lipid Medicine and Technology is dedicated to generating knowledge on the roles of lipids in human biology and their impact on human health, as well as developing novel medicine and technologies for disease management and health promotion.
Leukocyte trafficking in health and disease - Mora Laboratory
Understanding the impact of leukocyte trafficking in gastrointestinal and systemic immunity in health and disease
Light Microscopy and Image Analysis Core
Includes state-of-the art Nikon upright (80i) and inverted (TE2000-U) microscopes.
Mucosal Immunology, Microbial Defense and Inflammatory Bowel Diseases - Reinecker Laboratory
We uncover the genetic basis and molecular mechanisms of microbial recognition and immune regulation in the digestive tract.
Murat Bastepe, MD, PhD
Our broad goal is to understand the role of the complex GNAS locus in physiology and in disease.
Neuroendocrine Clinical Research Program
Learn more about clinical research in the Neuroendocrine Unit at Mass General.
Rajagopal Lab
Our laboratory focuses on organ regeneration and the application of developmental biology to human disease. We focus on the lung as a model system since there is an abundance of respiratory diseases of unknown cause without cures.
Ramaswamy Lab
Our major goal is to identify important cancer gene networks that are essential in human cancer metastasis and drug resistance, to guide the development and clinical use of new cancer drugs and diagnostics.
Research in Inflammatory Bowel Diseases - Dr. Ashwin Ananthakrishnan
My research focuses on research in epidemiology and outcomes of inflammatory bowel diseases and development of personalized medicine approach.
Scadden Lab
The Scadden lab focuses on hematopoietic stem cells and their niche with the intent of developing new therapies for blood disorders and malignancies.
Xavier Laboratory
The primary research goal of the Xavier Laboratory at Massachusetts General Hospital is to discover and understand the function of important mediators and effectors involved in both the innate and adaptive immune systems. Of particular interest are the cellular components and regulatory networks that interact dynamically within temporal, spatial, and pathophysiological contexts of innate immunity. 1. Systems biology of innate and adaptive immunity 2. Functional mapping of pathways associated with Crohn's disease, ulcerative colitis, and diabetes 3. Genetics of Crohn's disease, celiac disease and ulcerative colitis
Yajnik Lab
My principal interest is to understand the molecular basis of cancer progression.
