In addition to leading the way in clinical care, the Department of Medicine plays an instrumental role in advancing biomedical research and developing new therapies for disease. One of the top departmental recipients of funding from the National Institutes of Health, our thriving research enterprise hosts an extremely diverse portfolio of investigation in basic science and clinical research.
Our lab interests lie at the interface between adult stem cell biology and tissue regeneration. We focus on the molecular pathways that control cell fate decisions of the adult muscle stem cell (the satellite cell) to effectively regenerate adult skeletal muscle.
Cost Effectiveness of Preventing AIDS Complications (CEPAC) is an HIV clinical modeling team that compares the effectiveness of different HIV treatment strategies, in collaboration with investigators around the world.
Our research is focused on understanding the contribution of environmental and genetic factors in the development of disease. We are building in vitro models using human embryonic stem cells, in which genetic and developmental aspects of the disease can be controlled.
Our lab uses zebrafish as a genetic model system to understand how kidney cells are formed during embryonic development. We are currently using genetic screens, morpholino-mediated gene knockdown, and the generation of inducible transgenic lines to unravel the transcriptional networks governing renal development.
The MGH Diabetes Clinical Research Center, currently in its 20th year, focuses on the development and evaluation of innovative therapies for Type 1 and Type 2 diabetes and their complications.
For over two decades, the Mass General Diabetes Clinical Research Center has developed and evaluated innovative therapies for Type 1 and Type 2 diabetes.
Our laboratory is committed to expanding our molecular understanding of the formation and regeneration of the musculoskeletal system. We are particularly focused on tendon and ligament biology with the goal of translating our discoveries into clinical therapies.
My laboratory focuses on understanding the biology of pluripotent stem cells. We aim to develop novel human models for development and disease, to ultimately enable the application of cell- or tissue-based therapies for the treatment of degenerative disease.
Our laboratory seeks to gain new insights into the molecular pathogenesis of tumors of the GI tract. Our particular areas of interest are colon cancer, neuroendocrine tumors, angiogenesis, hypoxia, hereditary cancers, and genetic instability. We seek to identify molecular targets that can ultimately guide therapeutic strategies.
The purpose of the human embryonic stem cell (hESC) Core Facility is to provide an institutional resource for hESC research at Massachusetts General Hospital.
Our lab tries to understand the role stem cells play in normal development and disease.
Our laboratory is interested in the transcriptional regulation of normal blood cell development and leukemia.
Offers custom-built instrumentation for cell sorting and data analysis.
Our Main Research Interests: Intestinal epithelial cell homeostasis under normal and inflammatory conditions; Role of epithelial cells in innate and acquired immune response; Cellular and molecular biology of mucosal immunity.
The Laboratory for Lipid Medicine and Technology is dedicated to generating knowledge on the roles of lipids in human biology and their impact on human health, as well as developing novel medicine and technologies for disease management and health promotion.
Understanding the impact of leukocyte trafficking in gastrointestinal and systemic immunity in health and disease
Includes state-of-the art Nikon upright (80i) and inverted (TE2000-U) microscopes.
The research in the Medoff Laboratory is dedicated to understanding the molecular basis of immune-mediated lung injury.
We uncover the genetic basis and molecular mechanisms of microbial recognition and immune regulation in the digestive tract.
Our broad goal is to understand the role of the complex GNAS locus in physiology and in disease.
Learn more about clinical research in the Neuroendocrine Unit at Mass General.
Our laboratory focuses on organ regeneration and the application of developmental biology to human disease. We focus on the lung as a model system since there is an abundance of respiratory diseases of unknown cause without cures.
Research topics include: Cancer Genetics and Genomics; Progression; Invasion and Metastasis; Drug and Treatment Resistance; Computational and Systems Biology.
My research focuses on research in epidemiology and outcomes of inflammatory bowel diseases and development of personalized medicine approach.
The Scadden lab focuses on hematopoietic stem cells and their niche with the intent of developing new therapies for blood disorders and malignancies.
The primary research goal of the Xavier Laboratory at Massachusetts General Hospital is to discover and understand the function of important mediators and effectors involved in both the innate and adaptive immune systems. Of particular interest are the cellular components and regulatory networks that interact dynamically within temporal, spatial, and pathophysiological contexts of innate immunity. 1. Systems biology of innate and adaptive immunity 2. Functional mapping of pathways associated with Crohn's disease, ulcerative colitis, and diabetes 3. Genetics of Crohn's disease, celiac disease and ulcerative colitis
My principal interest is to understand the molecular basis of cancer progression.