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The Massachusetts General Hospital Department of Medicine provides leading-edge basic, clinical, and translational research through our research units and divisions.
The Analytic and Translational Genetics Unit focuses on the interpretation of individual genome sequence data for the discovery of the genetic underpinnings of human disease and for development of paradigms for clinical decision making
The Biostatistics Center provides statistical and data management support to Mass General investigators and serves as a coordinating center for several projects supported by the National Institutes of Health. The center's staff includes biostatisticians, physicians, research nurses, data managers, project managers, research assistants and computing staff
The Center for Assessment Technology and Continuous Health (CATCH) is a collaboration of experts discovering new health measurements and technology to better diagnose and treat diseases within a patient’s daily life.
The Center for Immunology and Inflammatory Diseases (CIID) is a multidisciplinary research center focused on basic mechanisms of immunemediated inflammatory diseases.
The Clinical and Translational Epidemiology Unit advances the translation of discoveries into effective clinical interventions in chronic disease through epidemiologic investigation.
The Disparities Research Unit (DRU) conducts innovative health and health services research focused on improving access and care for diverse populations.
The Laboratory of Computer Science supports the department's clinical and research information systems and conducts research into the application of computer technology in medical record systems, physician workstations, clinical problem solving, expert systems in medical diagnosis, knowledge management and clinical research.
The Medical Practice Evaluation Center (MPEC) works to improve clinical outcomes, increase value in health policy, and inform global public health through innovative research, collaboration and education.
The Mongan Institute of the Department of Medicine is comprised of seven thematic research centers and units including the Cancer Outcomes Research Program, the Clinical and Translational Epidemiology Unit, the Disparities Research Unit, the Disparities Solutions Center, the Global Health Research Center, the Medical Practice Evaluation Center, and the Mongan Institute Health Policy Center. It is the mission of The Mongan Institute to support and advance research in the areas of population, policy and health care sciences.
The Mongan Institute Health Policy Center aims to catalyze beneficial changes in health policy, the health and care of disadvantaged populations, and the health care delivery system.
The Vaccine & Immunotherapy Center (VIC) at was established to speed the translation of laboratory discoveries into new, cost-effective therapies and treatments to prevent and cure various forms of cancer and infectious diseases.
Our laboratory has been involved in uncovering the mechanisms by which hepatitis viruses, particularly hepatitis C virus, persist in the liver and cause liver damage. Our projects will advance care of patients with liver diseases through enhanced understanding of what causes chronic viral infection, and will help to identify novel drugs to help treat patients who have been nonresponders or ineligible to receive current treatments.nonresponders or ineligible to receive current treatments.
The Allergy Clinical Research Unit conducts clinical "translational" research and drug trials of allergic and immunologic diseases, including asthma, chronic rhinosinusitis, nasal polyopsis, drug allergy, hereditary angioedema (HAE) and food allergy.
The Tager Laboratory at Massachusetts General Hospital investigates (1) pulmonary and dermal fibrosis, focusing on the roles lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), and (2) HIV immunopathogenesis, using a novel mouse model of HIV infection.
The Acute Respiratory Distress Syndrome (ARDS) Network Clinical Coordinating Center coordinates randomized controlled trials for patients with ARDS.
The M. Amin Arnaout laboratory is interested in elucidating the molecular basis of human disease and in using this information to guide development of new and safer therapies. We utilize state-of-the-art technologies, including genetics, genomics, biochemistry, cell biology, structural and computational biology and animal models of disease.
The Jodie L. Babitt Lab is focused on elucidating the molecular and cellular mechanisms involved in iron homeostasis
The basic and translational research in the Diabetes Unit at Massachusetts General Hospital focuses on studies relating to insulin resistance and developing novel prevention strategies and treatments.
The Medoff Laboratory at Massachusetts General Hospital studies the pathogenesis of pulmonary inflammation in a number of important lung diseases such as asthma, COPD, lung transplant rejection, and viral infections.
The Richard Bouley Laboratory is studying the role of vasopressin receptor type 2 in the pathophysiology of diseases associated with water reabsorption dysregulation.
The Sylvie Breton laboratory studies the regulation of epithelial cells in the urogenital tract with an emphasis on the kidney and epididymis. Our main areas of interest include: acute kidney injury, chronic kidney disease, male infertility, cystic fibrosis, acid/base homeostasis.
The Dennis Brown Laboratory uses cell biological and imaging techniques to understand mechanisms and physiological signals that regulate the distribution of important proteins in the kidney that regulate urine concentration and systemic acid base balance. We are especially interested in the pathophysiology of vasopressin activated water channels (aquaporins), and in proton pump (V-ATPase) function.
Dr. Brugge is an active clinical consultant in gastroenterology and gastrointestinal endoscopy, focusing on patients with complex pancreatic diseases. His research has focused on the early diagnosis of pancreatic cancer, developing a variety of endoscopic techniques to aspirate malignant and pre-malignant lesions of the pancreas.
We are scientists, engineers and physicians who are bringing the cutting edge of technology to the forefront of biomedical research and the practice of medicine.
Our research focuses on understanding the pathogenesis of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis (NASH), the interaction between obstructive sleep apnea (OSA) and NASH, and the influence of NASH on lipid metabolism and cardiovascular risk factors.
Dr. Dienstag is an experienced clinical investigator in the area of viral hepatitis (trials of antiviral therapies for chronic hepatitis B and C). Between 2000 and 2010, he was the site-PI of a national trial of maintenance antiviral therapy for patients refractory to treatment for chronic hepatitis C, the Hepatitis C Antiviral Long-term Treatment against Cirrhosis (HALT-C) Trial.
Modeling Cardiovascular and Metabolic Disease with Human Pluripotent Stem Cells
The Critical Care Translational Medicine Group designs, oversees and coordinates international trials in acute respiratory distress syndrome (ARDS) and sepsis.
The Nicolas Da Silva Laboratory focuses on interactions between the immune system and the male reproductive tract, specifically on the importance of macrophages and dendritic cells during sperm maturation and storage.
Molecular Epidemiology of ARDS:
Under the direction of David Christiani, MD, MPH, our laboratory examines genetic and environmental factors that may impact the development and progression of acute respiratory distress syndrome (ARDS).
Our lab uses zebrafish as a genetic model system to understand how kidney cells are formed during embryonic development. We are currently using genetic screens, morpholino-mediated gene knockdown, and the generation of inducible transgenic lines to unravel the transcriptional networks governing renal development.
The MGH Diabetes Clinical Research Center, currently in its 20th year, focuses on the development and evaluation of innovative therapies for Type 1 and Type 2 diabetes and their complications.
For over two decades, the Massachusetts General Hospital Diabetes Clinical Research Center has developed and evaluated innovative therapies for type 1 and type 2 diabetes.
The Iain Drummond Laboratory studies kidney organogenesis using the zebrafish to explore conserved molecular mechanisms underlying vertebrate kidney cell differentiation, morphogenesis, ciliogenesis, and regeneration.
Research in the Endocrine Unit focuses on metabolic bone diseases and mineral metabolism and ranges from trials of novel therapies for osteoporosis to use of genetically altered mice and cell biology to understand the factors that influence calcium and phosphate metabolism.
The Bastepe Laboratory at Massachusetts General Hospital investigates the role of the GNAS locus and its gene products in physiology and disease pathogenesis.
The Demay Laboratory at Massachusetts General Hospital is focused on understanding the role of the vitamin D receptor (VDR) in skeletal maturation and in cutaneous homeostasis.
The Kobayashi Laboratory at Massachusetts General Hospital investigates the genetics of skeletal development.
The Kronenberg Laboratory at Massachusetts General Hospital uses genetically altered mice to study signaling by the PTH/PTHrP receptor in bone, bone development more generally and the relationships between cells of the osteoblast lineage and hematopoiesis.
Research in the Mannstadt Laboratory at Massachusetts General Hospital focuses on diseases of the parathyroid glands and mineral metabolism.
Thomas Gardella, PhD, is an Assistant Professor in Medicine and Biochemistry in the Massachusetts General Hospital Endocrine Unit, and conducts basic research on parathyroid hormone (PTH) and the PTH receptor.
The Eugene Rhee Laboratory is interested in several aspects of renal metabolism, with the goal to understand how alterations in energy metabolism contribute to kidney disease pathogenesis and its complications and to discover metabolite markers of CKD and its progression.
The Fitzgerald Laboratory explores the molecular mechanisms that cells use to export cholesterol and phospholipid to extracellular acceptor proteins, a process termed lipid efflux. We study how this process generates HDL and how HDL can modulate the innate immune system.
Our laboratory is committed to expanding our molecular understanding of the formation and regeneration of the musculoskeletal system. We are particularly focused on tendon and ligament biology with the goal of translating our discoveries into clinical therapies.
My laboratory focuses on understanding the biology of pluripotent stem cells. We aim to develop novel human models for development and disease, to ultimately enable the application of cell- or tissue-based therapies for the treatment of degenerative disease.
Our laboratory seeks to gain new insights into the molecular pathogenesis of tumors of the GI tract. Our particular areas of interest are colon cancer, neuroendocrine tumors, angiogenesis, hypoxia, hereditary cancers, and genetic instability. We seek to identify molecular targets that can ultimately guide therapeutic strategies.
Functions of RNA Chemical Modifications (Epitranscriptomes) in Health and Disease
Research within the Marcia B. Goldberg, MD Laboratory focuses on the molecular nature of interactions between microbial pathogens and the host and the development of rapid diagnostics for infectious diseases.
The Jason Harris, MD, MPH and Regina LaRocque, MD, MPH Laboratory is focused on host-pathogen interactions and the innate and adaptive immune response to Vibrio cholerae, cholera vaccines, and in the area of susceptibility to cholera.
Our lab tries to understand the role stem cells play in normal development and disease.
Our laboratory is interested in the transcriptional regulation of normal blood cell development and leukemia.
Our research focuses on applying outcomes methodologies to the clinical field of gastroenterology. Specific examples include the use of decision-analytic modeling to perform comparative effectiveness research regarding the screening and management of various gastrointestinal cancers and diseases.
Our Main Research Interests: Intestinal epithelial cell homeostasis under normal and inflammatory conditions; Role of epithelial cells in innate and acquired immune response; Cellular and molecular biology of mucosal immunity.
The Moon Laboratory at Massachusetts General Hospital investigates basic issues of CD4+ T cell tolerance by directly tracking endogenous antigen-specific populations in mice and humans.
The Laboratory for Lipid Medicine and Technology is dedicated to generating knowledge on the roles of lipids in human biology and their impact on human health, as well as developing novel medicine and technologies for disease management and health promotion.
The Laboratory of Computer Science at Massachusetts General Hospital—the Clinical and Research Informatics Division of the Department of Medicine—explores innovative applications of clinical technology in health care.
Understanding the human immune response against viruses, with a focus on T-cell responses targeting human hepatotropic viruses (Hepatitis C Virus (HCV), Hepatitis B Virus (HBV), HCV/HIV co-infection). Establishing the groundwork for rational design of antiviral vaccines and immunotherapies.
The Herbert Lin Laboratory studies the role of the TGF-beta/BMP signaling pathways in health and disease.
Understanding how long noncoding RNAs regulate embryonic stem cell differentiation and liver fibrosis
The main focus in the Hua Lu Laboratory is to study the mechanism of the trafficking of a water channel protein, AQP2.
The Michael K. Mansour, MD, PhD Laboratory at Massachusetts General Hospital focuses on developing novel cellular diagnostics and therapies for invasive fungal infections.
The research in the Medoff Laboratory is dedicated to understanding the molecular basis of immune-mediated lung injury.
We uncover the genetic basis and molecular mechanisms of microbial recognition and immune regulation in the digestive tract.
Our broad goal is to understand the role of the complex GNAS locus in physiology and in disease.
Learn more about clinical research in the Neuroendocrine Unit at Massachusetts General Hospital.
Learn more about basic research the the Neuroendocrine Unit at Massachusetts General Hospital.
The laboratory is focused upon clinical and translational research in GI Motility and Visceral Pain Syndromes such as GERD, gastroparesis, constipation and irritable bowel syndrome.
The Teodor Paunescu Laboratory studies proton secretion in the kidney and the olfactory epithelium, and its relevance for maintaining body acid-base balance, the sense of smell, and nutrition.
We have discovered that the cholesterol biosynthetic pathway is critically important to the hepatitis C viral lifecycle and are examining this relationship further.
The PSC Registry at Massachusetts General Hospital is a database and tissue repository established to be a resource for clinical and basic science investigators studying primary sclerosing cholangitis.
Our laboratory focuses on organ regeneration and the application of developmental biology to human disease. We focus on the lung as a model system, in part due to the abundance of respiratory diseases of unknown causes and without cures.
Research topics include: Cancer Genetics and Genomics; Progression; Invasion and Metastasis; Drug and Treatment Resistance; Computational and Systems Biology.
My research focuses on research in epidemiology and outcomes of inflammatory bowel diseases and development of personalized medicine approach.
The Rheumatology Clinical Research Unit at Massachusetts General Hospital performs state-of-the-art translational research for patients with immune-mediated and rheumatological conditions.
The Edward T. Ryan, MD Laboratory’s research focuses on host-bacterial pathogen interactions and immune responses, with a particular focus on enteric infections and the development of vaccines protective against enteric infections, and development of diagnostic assays.
The Scadden lab focuses on hematopoietic stem cells and their niche with the intent of developing new therapies for blood disorders and malignancies.
The Harris Lab is a multi-disciplinary, inter-departmental group of investigators aiming to advance the understanding of whole-organ physiology and pathophysiology of the human lung through the development and implementation of advanced imaging techniques, sophisticated mathematical and computer modeling and bioengineering. In our studies, we apply rigorous quantitative tools to investigate the complex structure-function relationships of healthy and diseased lungs.
The Sanja Sever Laboratory's research focuses on podocyte structure and function, the large regulatory GTPase dynamin, as well as the intersection of these two areas.
The overall focus of the Roy Soberman Laboratory is to understand signal integration and macromolecular organization in cells of the immune system, and how these processes are linked to control the amplification of the immune response.
We study transcriptional regulation of gastrointestinal and hepatobiliary development and its application to regenerative medicine and cancer.
The focus of the Pulmonary Optical Imaging Laboratory is the development and subsequent translation of novel optical diagnostic tools for evaluating the pulmonary airways and lung.
The Ravi Thadhani Laboratory's research efforts are divided into two main areas: Pregnancy and Dialysis. Pregnancy related studies have centered on human studies supporting basic science collaborations in the area of angiogenic factors and preeclampsia. In dialysis, we have conducted studies examining the effect of vitamin D in the survival of chronic hemodialysis patients.
The Program in Nutritional Metabolism at Massachusetts General Hospital was formed under the direction of Dr. Steven Grinspoon, a recognized expert in the nutritional regulation of pituitary function and the metabolic consequences of obesity and fat redistribution.
The Jatin Vyas, MD, PhD Laboratory at Massachusetts General Hospital focuses on the innate immune response to invasive fungal infections.
The Warren Laboratory researches the pathogenesis and treatment of serious bacterial infections, sepsis, and induced secondary inflammation from any cause.
The Winfred Williams Laboratory studies the genetic basis of chronic allograft nephropathy.
The David Wojciechowski Laboratory's clinical research is focused on the prevention and treatment of viral infection post-kidney transplant, improving access to transplantation, and the evaluation of immunosuppressive regimens focusing on novel agents and drug combinations in order to maximize patient and graft outcomes and minimize toxicity.
The primary research goal of the Xavier Laboratory is to discover and understand the function of important mediators and effectors involved in the innate and adaptive immune systems. Of particular interest are the cellular components and regulatory networks that interact dynamically within temporal, spatial, and pathophysiological contexts of innate immunity. Current themes of the lab include (1) systems biology of innate and adaptive immunity, (2) functional mapping of pathways associated with Crohn's disease, ulcerative colitis and diabetes, and (3) genetics of Crohn's disease, celiac disease and ulcerative colitis.
My principal interest is to understand the molecular basis of cancer progression.
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