Our Research

The Massachusetts General Hospital Department of Medicine provides leading-edge basic, clinical, and translational research through our research units and divisions.

Research Units

  • Analytic and Translational Genetics Unit

    The Analytic and Translational Genetics Unit focuses on the interpretation of individual genome sequence data for the discovery of the genetic underpinnings of human disease and for development of paradigms for clinical decision making

  • Biostatistics Center

    The Biostatistics Center provides statistical and data management support to Mass General investigators and serves as a coordinating center for several projects supported by the National Institutes of Health. The center's staff includes biostatisticians, physicians, research nurses, data managers, project managers, research assistants and computing staff

  • Center for Assessment Technology and Continuous Health (CATCH)

    The Center for Assessment Technology and Continuous Health (CATCH) is a collaboration of experts discovering new health measurements and technology to better diagnose and treat diseases within a patient’s daily life.

  • Clinical and Translational Epidemiology Unit

    The Clinical and Translational Epidemiology Unit advances the translation of discoveries into effective clinical interventions in chronic disease through epidemiologic investigation.

  • Disparities Research Unit

    The Disparities Research Unit (DRU) conducts innovative health and health services research focused on improving access and care for diverse populations.

  • Laboratory of Computer Science

    The Laboratory of Computer Science supports the department's clinical and research information systems and conducts research into the application of computer technology in medical record systems, physician workstations, clinical problem solving, expert systems in medical diagnosis, knowledge management and clinical research.

  • Medical Practice Evaluation Center

    The Medical Practice Evaluation Center (MPEC) works to improve clinical outcomes, increase value in health policy, and inform global public health through innovative research, collaboration and education.

  • Mongan Institute Health Policy Center

    The Mongan Institute Health Policy Center aims to catalyze beneficial changes in health policy, the health and care of disadvantaged populations, and the health care delivery system.

  • Vaccine & Immunotherapy Center

    The Vaccine & Immunotherapy Center (VIC) at was established to speed the translation of laboratory discoveries into new, cost-effective therapies and treatments to prevent and cure various forms of cancer and infectious diseases.

Research Labs

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  • Advancing Understanding of Mechanisms of Hepatitis-Related Liver Disease (Chung Laboratory)

    Raymond Chung

    Our laboratory has been involved in uncovering the mechanisms by which hepatitis viruses, particularly hepatitis C virus, persist in the liver and cause liver damage. Our projects will advance care of patients with liver diseases through enhanced understanding of what causes chronic viral infection, and will help to identify novel drugs to help treat patients who have been nonresponders or ineligible to receive current treatments.nonresponders or ineligible to receive current treatments.

  • Allergy Clinical Research Unit

    The Allergy Clinical Research Unit conducts clinical "translational" research and drug trials of allergic and immunologic diseases, including asthma, chronic rhinosinusitis, nasal polyopsis, drug allergy, hereditary angioedema (HAE) and food allergy.

  • Andrew Tager, MD

    Photo of Dr. Andrew Tager

    The Tager Laboratory at Massachusetts General Hospital investigates (1) pulmonary and dermal fibrosis, focusing on the roles lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), and (2) HIV immunopathogenesis, using a novel mouse model of HIV infection.

  • ARDS Network Clinical Coordinating Center

    David Schoenfeld, PhD

    The Acute Respiratory Distress Syndrome (ARDS) Network Clinical Coordinating Center coordinates randomized controlled trials for patients with ARDS.

  • Arnaout Laboratory

    The M. Amin Arnaout laboratory is interested in elucidating the molecular basis of human disease and in using this information to guide development of new and safer therapies. We utilize state-of-the-art technologies, including genetics, genomics, biochemistry, cell biology, structural and computational biology and animal models of disease.

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  • Babitt Laboratory

    Jodie Babitt, MD

    The Jodie L. Babitt Lab is focused on elucidating the molecular and cellular mechanisms involved in iron homeostasis

  • Benjamin Medoff, MD

    Photo of Benjamin Medoff, MD

    The Medoff Laboratory at Massachusetts General Hospital studies the pathogenesis of pulmonary inflammation, specifically the role of T cells in mediating inflammatory lung diseases.

  • Bhan Laboratory

    Ishir Bhan, MD, MPH

    The Ishir Bhan Laboratory's research focuses on vitamin D and the immune system in humans, particularly in the setting of renal disease.

  • Bouley Laboratory

    Richard Bouley, PhD

    The Richard Bouley Laboratory is studying the role of vasopressin receptor type 2 in the pathophysiology of diseases associated with water reabsorption dysregulation.

  • Breton Laboratory

    Sylvie Breton, PhD

    The Sylvie Breton laboratory studies the regulation of epithelial cells in the urogenital tract with an emphasis on the kidney and epididymis. Our main areas of interest include: acute kidney injury, chronic kidney disease, male infertility, cystic fibrosis, acid/base homeostasis.

  • Brown Laboratory

    Dennis Brown, PhD

    The Dennis Brown Laboratory uses cell biological and imaging techniques to understand mechanisms and physiological signals that regulate the distribution of important proteins in the kidney that regulate urine concentration and systemic acid base balance. We are especially interested in the pathophysiology of vasopressin activated water channels (aquaporins), and in proton pump (V-ATPase) function.

  • Brugge Research

    Dr. Brugge

    Dr. Brugge is an active clinical consultant in gastroenterology and gastrointestinal endoscopy, focusing on patients with complex pancreatic diseases. His research has focused on the early diagnosis of pancreatic cancer, developing a variety of endoscopic techniques to aspirate malignant and pre-malignant lesions of the pancreas.

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  • Center for Engineering in Medicine

    We are scientists, engineers and physicians who are bringing the cutting edge of technology to the forefront of biomedical research and the practice of medicine.

  • Clinical Investigation in Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis

    Our research focuses on understanding the pathogenesis of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis (NASH), the interaction between obstructive sleep apnea (OSA) and NASH, and the influence of NASH on lipid metabolism and cardiovascular risk factors.

  • Clinical trials of antiviral therapy for chronic viral hepatitis - Dienstag

    Dr. Dienstag Research

    Dr. Dienstag is an experienced clinical investigator in the area of viral hepatitis (trials of antiviral therapies for chronic hepatitis B and C). Between 2000 and 2010, he was the site-PI of a national trial of maintenance antiviral therapy for patients refractory to treatment for chronic hepatitis C, the Hepatitis C Antiviral Long-term Treatment against Cirrhosis (HALT-C) Trial.

  • Cowan Lab

    Modeling Cardiovascular and Metabolic Disease with Human Pluripotent Stem Cells

  • Critical Care Translational Medicine Group

    Critical Care Translational Medicine Group

    The Critical Care Translational Medicine Group designs, oversees and coordinates international trials in acute respiratory distress syndrome (ARDS) and sepsis.

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  • Da Silva Laboratory

    Nicolas Da Silva, PhD

    The Nicolas Da Silva Laboratory focuses on interactions between the immune system and the male reproductive tract, specifically on the importance of macrophages and dendritic cells during sperm maturation and storage.

  • David Christiani, MD, MPH

    David Christiani, MD, MPH

    Molecular Epidemiology of ARDS: Under the direction of David Christiani, MD, MPH, our laboratory examines genetic and environmental factors that may impact the development and progression of acute respiratory distress syndrome (ARDS).

  • Davidson Lab

    Our lab uses zebrafish as a genetic model system to understand how kidney cells are formed during embryonic development. We are currently using genetic screens, morpholino-mediated gene knockdown, and the generation of inducible transgenic lines to unravel the transcriptional networks governing renal development.

  • Diabetes Research Center

    The MGH Diabetes Clinical Research Center, currently in its 20th year, focuses on the development and evaluation of innovative therapies for Type 1 and Type 2 diabetes and their complications.

  • Diabetes Research Center

    For over two decades, the Massachusetts General Hospital Diabetes Clinical Research Center has developed and evaluated innovative therapies for type 1 and type 2 diabetes.

  • Dr. Cosmas Giallourakis

    Cosmas Giallourakis

    Functions of RNA Chemical Modifications (Epitranscriptomes) in Health and Disease

  • Drummond Laboratory

    Iain Drummond, PhD

    The Iain Drummond Laboratory studies kidney organogenesis using the zebrafish to explore conserved molecular mechanisms underlying vertebrate kidney cell differentiation, morphogenesis, ciliogenesis, and regeneration.

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  • Endocrine Unit Research

    Research in the Endocrine Unit focuses on metabolic bone diseases and mineral metabolism and ranges from trials of novel therapies for osteoporosis to use of genetically altered mice and cell biology to understand the factors that influence calcium and phosphate metabolism.

  • Endocrine Unit: Bastepe Laboratory

    The Bastepe Laboratory at Massachusetts General Hospital investigates the role of the GNAS locus and its gene products in physiology and disease pathogenesis.

  • Endocrine Unit: Bergwitz Laboratory

    Endocrine Unit: Bergwitz Laboratory

    Our research focuses on inborn errors of phosphate metabolism and the endocrine regulation of phosphate homeostasis with an emphasis on the metabolic and homeostatic effects of phosphate.

  • Endocrine Unit: Demay Laboratory

    Endocrine Unit: Demay Laboratory

    The Demay Laboratory at Massachusetts General Hospital is focused on understanding the role of the vitamin D receptor (VDR) in skeletal maturation and in cutaneous homeostasis.

  • Endocrine Unit: Divieti Pajevic Laboratory

    Endocrine Unit: Divieti Pajevic Laboratory

    The Divieti-Pajevic Laboratory of the Massachusetts General Hospital Endocrine Unit investigates the complex interactions involved in bone metabolism.

  • Endocrine Unit: Kobayashi Laboratory

    Endocrine Unit: Kobayashi Laboratory

    The Kobayashi Laboratory at Massachusetts General Hospital investigates the genetics of skeletal development.

  • Endocrine Unit: Kronenberg Laboratory

    The Kronenberg Laboratory at Massachusetts General Hospital uses genetically altered mice to study signaling by the PTH/PTHrP receptor in bone, bone development more generally and the relationships between cells of the osteoblast lineage and hematopoiesis.

  • Endocrine Unit: Mannstadt Laboratory

    Endocrine Unit: Mannstadt Laboratory

    Research in the Mannstadt Laboratory at Massachusetts General Hospital focuses on diseases of the parathyroid glands and mineral metabolism.

  • Endocrine Unit: Shimada Laboratory

    Endocrine Unit: Shimada Laboratory

    The Shimada Laboratory of the Massachusetts General Hospital Endocrine Unit investigates the complex interactions involved in bone development and remodeling.

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  • Fitzgerald Laboratory

    Michael L. Fitzgerald, PhD

    The Fitzgerald Laboratory explores the molecular mechanisms that cells use to export cholesterol and phospholipid to extracellular acceptor proteins, a process termed lipid efflux. We study how this process generates HDL and how HDL can modulate the innate immune system.

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  • Galloway Lab

    Our laboratory is committed to expanding our molecular understanding of the formation and regeneration of the musculoskeletal system. We are particularly focused on tendon and ligament biology with the goal of translating our discoveries into clinical therapies.

  • Geijsen Lab

    My laboratory focuses on understanding the biology of pluripotent stem cells. We aim to develop novel human models for development and disease, to ultimately enable the application of cell- or tissue-based therapies for the treatment of degenerative disease.

  • GI Cancers - Daniel C. Chung Laboratory

    Dr. Daniel Chung

    Our laboratory seeks to gain new insights into the molecular pathogenesis of tumors of the GI tract. Our particular areas of interest are colon cancer, neuroendocrine tumors, angiogenesis, hypoxia, hereditary cancers, and genetic instability. We seek to identify molecular targets that can ultimately guide therapeutic strategies.

  • Goldberg Laboratory

    Marcia Goldberg, MD

    Research within the Marcia B. Goldberg, MD Laboratory focuses on the molecular nature of interactions between microbial pathogens and the host and the development of rapid diagnostics for infectious diseases.

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  • Harris & LaRocque Laboratory

    Harris & LaRocque Laboratory

    The Jason Harris, MD, MPH and Regina LaRocque, MD, MPH Laboratory is focused on host-pathogen interactions and the innate and adaptive immune response to Vibrio cholerae, cholera vaccines, and in the area of susceptibility to cholera.

  • Hochedlinger Lab

    Our lab tries to understand the role stem cells play in normal development and disease.

  • Hock Lab

    Our laboratory is interested in the transcriptional regulation of normal blood cell development and leukemia.

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  • James Moon, PhD

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    The Moon Laboratory at Massachusetts General Hospital investigates basic issues of CD4+ T cell tolerance by directly tracking endogenous antigen-specific populations in mice and humans.

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  • Laboratory for Lipid Medicine and Technology

    Laboratory for Lipid Medicine and Technology

    The Laboratory for Lipid Medicine and Technology is dedicated to generating knowledge on the roles of lipids in human biology and their impact on human health, as well as developing novel medicine and technologies for disease management and health promotion.

  • Laboratory of Computer Science

    Laboratory of Computer Science

    The Laboratory of Computer Science at Massachusetts General Hospital—the Clinical and Research Informatics Division of the Department of Medicine—explores innovative applications of clinical technology in health care.

  • Lauer Laboratory – Immunology of Viral Infections in Humans

    Dr. Lauer

    Understanding the human immune response against viruses, with a focus on T-cell responses targeting human hepatotropic viruses (Hepatitis C Virus (HCV), Hepatitis B Virus (HBV), HCV/HIV co-infection). Establishing the groundwork for rational design of antiviral vaccines and immunotherapies.

  • Lin Laboratory

    Herbert Lin, MD, PhD

    The Herbert Lin Laboratory studies the role of the TGF-beta/BMP signaling pathways in health and disease.

  • Lu Laboratory

    Hua Lu, MD, PhD

    The main focus in the Hua Lu Laboratory is to study the mechanism of the trafficking of a water channel protein, AQP2.

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  • Rajagopal Lab

    Our laboratory focuses on organ regeneration and the application of developmental biology to human disease. We focus on the lung as a model system, in part due to the abundance of respiratory diseases of unknown causes and without cures.

  • Ramaswamy Lab

    Research topics include: Cancer Genetics and Genomics; Progression; Invasion and Metastasis; Drug and Treatment Resistance; Computational and Systems Biology.

  • Research in Inflammatory Bowel Diseases - Dr. Ashwin Ananthakrishnan

    My research focuses on research in epidemiology and outcomes of inflammatory bowel diseases and development of personalized medicine approach.

  • Rhee Laboratory

    Eugene Rhee, MD

    The Eugene Rhee Laboratory is interested in several aspects of renal metabolism, with the goal to understand how alterations in energy metabolism contribute to kidney disease pathogenesis and its complications and to discover metabolite markers of CKD and its progression.

  • Rheumatology Clinical Research Unit

    The Rheumatology Clinical Research Unit at Massachusetts General Hospital performs state-of-the-art translational research for patients with immune-mediated and rheumatological conditions.

  • Ryan Laboratory

    Edward Ryan, MD

    The Edward T. Ryan, MD Laboratory’s research focuses on host-bacterial pathogen interactions and immune responses, with a particular focus on enteric infections and the development of vaccines protective against enteric infections, and development of diagnostic assays.

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  • Scadden Lab

    The Scadden lab focuses on hematopoietic stem cells and their niche with the intent of developing new therapies for blood disorders and malignancies.

  • Scott Harris, MD

    Scott Harris, MD

    The Harris Lab is a multi-disciplinary, inter-departmental group of investigators aiming to advance the understanding of whole-organ physiology and pathophysiology of the human lung through the development and implementation of advanced imaging techniques, sophisticated mathematical and computer modeling and bioengineering. In our studies, we apply rigorous quantitative tools to investigate the complex structure-function relationships of healthy and diseased lungs.

  • Sever Laboratory

    Sanja Sever, PhD

    The Sanja Sever Laboratory's research focuses on podocyte structure and function, the large regulatory GTPase dynamin, as well as the intersection of these two areas.

  • Soberman Laboratory

    Roy Soberman, MD

    The overall focus of the Roy Soberman Laboratory is to understand signal integration and macromolecular organization in cells of the immune system, and how these processes are linked to control the amplification of the immune response.

  • Stem Cell Biology and Cellular Reprogramming Laboratory - Choi Laboratory

    Dr. Choi

    We study transcriptional regulation of gastrointestinal and hepatobiliary development and its application to regenerative medicine and cancer.

  • Suter Pulmonary Optical Imaging Laboratory

    Suter Pulmonary Optical Imaging Laboratory

    The focus of the Pulmonary Optical Imaging Laboratory is the development and subsequent translation of novel optical diagnostic tools for evaluating the pulmonary airways and lung.

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  • TGF-beta signaling in development and disease Mullen Laboratory

    Understanding how TGF-beta signaling regulates the activity of coding and non-coding genes in health and disease

  • Thadhani Laboratory

    Ravi Thadhani, MD, MPH

    The Ravi Thadhani Laboratory's research efforts are divided into two main areas: Pregnancy and Dialysis. Pregnancy related studies have centered on human studies supporting basic science collaborations in the area of angiogenic factors and preeclampsia. In dialysis, we have conducted studies examining the effect of vitamin D in the survival of chronic hemodialysis patients.

  • The Program in Nutritional Metabolism

    The Program in Nutritional Metabolism

    The Program in Nutritional Metabolism at Massachusetts General Hospital was formed under the direction of Dr. Steven Grinspoon, a recognized expert in the nutritional regulation of pituitary function and the metabolic consequences of obesity and fat redistribution.

  • Type 1 Diabetes Research | Immunobiology Laboratory

    Denise Faustman and Lab Members

    The Mass General Immunobiology Laboratory conducts basic and translational research focused on discovering novel treatments for autoimmune diseases, with a specific focus on type 1 diabetes.

  • Type 2 Diabetes Laboratory

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    The Type 2 Diabetes Laboratory at Massachusetts General Hospital focuses on studies relating to insulin resistance in type 2 diabetic patients.

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  • Vyas Laboratory

    Jatin Vyas, MD, PhD

    The Jatin Vyas, MD, PhD Laboratory at Massachusetts General Hospital focuses on the innate immune response to invasive fungal infections.

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  • Warren Laboratory

    H. Shaw Warren, MD

    The Warren Laboratory researches the pathogenesis and treatment of serious bacterial infections, sepsis, and induced secondary inflammation from any cause.

  • Williams Laboratory

    Winfred Williams, MD

    The Winfred Williams Laboratory studies the genetic basis of chronic allograft nephropathy.

  • Wojciechowski Laboratory

    David Wojciechowski, DO

    The David Wojciechowski Laboratory's clinical research is focused on the prevention and treatment of viral infection post-kidney transplant, improving access to transplantation, and the evaluation of immunosuppressive regimens focusing on novel agents and drug combinations in order to maximize patient and graft outcomes and minimize toxicity.

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  • Xavier Laboratory

    Dr. Xavier

    The primary research goal of the Xavier Laboratory is to discover and understand the function of important mediators and effectors involved in the innate and adaptive immune systems. Of particular interest are the cellular components and regulatory networks that interact dynamically within temporal, spatial, and pathophysiological contexts of innate immunity. Current themes of the lab include (1) systems biology of innate and adaptive immunity, (2) functional mapping of pathways associated with Crohn's disease, ulcerative colitis and diabetes, and (3) genetics of Crohn's disease, celiac disease and ulcerative colitis.

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  • Yajnik Lab

    Dr. Yajnik

    My principal interest is to understand the molecular basis of cancer progression.

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