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Our research focuses on two related scientific ideas:
Marcia B. Goldberg, MDProfessor of Medicine, Harvard Medical School
Heather D. Eshleman, PhD, postdoctoral fellow
Kelly A. Miller, PhD, postdoctoral fellow
Brian C. Russo, PhD, postdoctoral fellow
Alexandra Wiscovitch, post-baccalaureate student
Austin Hachey, technician
Our research focuses on the interface of bacterial pathogens with human cells. Most gram-negative bacterial pathogens use specialized secretion systems (“type III secretion systems”) to deliver virulence proteins into human cells during infection. The proteins that are delivered by this means (“effector proteins”) manipulate human signaling pathways, cytoskeletal dynamics, and innate and adaptive immune responses, in ways that promote disease. These effector proteins are absolutely necessary for disease. Using genome-wide screens, we identified human signaling pathways required for infection by the gram-negative bacterial pathogen Shigella flexneri. Shigella are important human pathogens that cause diarrhea and dysentery, predominantly in daycare centers, institutions, and developing regions of the world.
View a full list of our publications on PubMed.
Marcia B. Goldberg, MD
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