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The Center is a national referral center for the evaluation and treatment of pituitary tumors, recurrent pituitary adenomas, and tumors or disorders of the hypothalamic-pituitary region. The Center is ideally suited for the referral of patients with pituitary tumors, including prolactinomas, Cushing's disease, acromegaly, nonfunctioning pituitary tumors, recurrent pituitary adenomas, and pituitary and hypothalamic disorders which lead to adrenal, thyroid, ovarian, or testicular deficiency. Patients can be referred for the development of a treatment plan in conjunction with their primary physician, for a second opinion, or for ongoing management by the Center physicians.
The Neuroendocrine Clinical Center offers detailed outpatient evaluation through comprehensive office visits, complete basal and dynamic hormone testing, and coordination of radiological studies and visual field evaluations. All new patients are presented at the weekly Neuroendocrine Clinical Conference which is attended by endocrinologists, neurosurgeons, neurologists, and radiation therapy physicians. A diagnostic and therapeutic plan is formulated for each patient and provided to the referring physician.
The Center have a team of Endocrinologists who are experienced in the chronic administration of replacement hormones and in the use of drugs which block hormone excess syndromes. They are experienced in the use of investigational drugs for the treatment of prolactin and growth hormone disorders. They have been at the forefront of medical therapy for pituitary disorders with the use of new dopamine agonists for prolactinomas and somatostatin analogues for acromegaly. The Neurosurgical involvement in the Center ensures prompt surgical intervention when necessary and likewise input from the Department of Radiation Medicine facilitates the planning of therapy. Neurologists are available for the pharmacological treatment of headaches, seizures, and hypothalamic syndromes. The Center also has a nurse who offers patient education, including teaching self-administration of medications requiring injection.
The physicians in the Neuroendocrine Clinical Center also work closely with the department of Neurosurgery to provide cohesive care for several innovative treamtments. Many of our patients receive proton beam therapy and conventional radiation therapy for treatment of pituitary lesions. Laser-guided MR imaged stereotactic intrasellar tumor localization can be used for selected patients with untreated pituitary tumors, incomplete surgical resection, or tumor recurrence. In addition, an intraoperative MRI has recently been installed in the MGH neurosurgical operating suite. Unlike standard MRI facilities, this is a portable machine which is designed to be used in an operating room and provide real-time visualisation during all stages of brain surgery. For more information, please visit the Department of Neurosurgery's website http://neurosurgery.mgh.harvard.edu/.
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