Dr. Albers’ Laboratory uses the olfactory system of mice and humans to elucidate early pathologic events of neurodegeneration.
Dr. Arbel is a former Alzheimer’s Disease Research Unit fellow in the Neurology Department’s MassGeneral Institute for Neurodegenerative Disease, where she continues her research. She is a member of the Hyman Lab.
Dr. Bacskai's research is aimed at optimizing anti-amyloid-beta therapeutic approaches and--using multiphoton microscopy--imaging the anatomy and physiology of specific cell types in the brain before and after treatment.
Dr. Berezovska's research goal is to study the cellular and molecular mechanisms of Alzheimer's disease pathology. Her lab analyzes gamma-secretase and APP interactions, examining mechanisms by which certain factors modulate A beta production and/or regulate the precision of APP cleavage by gamma-secretase.
Paolo Ciccarese, PhD, is a member of the MIND Center for Interdisciplinary Informatics research core lab. His goal is to limit the episodes of lost knowledge in biomedical research and help scientists to capitalize on what is already known. His current work is on scientific discourse representation models, and annotation of digital resources in Alzheimer's disease research.
Dr. Clark researches neuroinformatics and semantic models of theory and evidence in biomedical research. Disease interest: Alzheimer's disease
Dr. Cudkowicz's research and clinical activities are dedicated to the study and treatment of patients with neurodegenerative disorders, in particular amyotrophic lateral sclerosis (ALS) and Huntington’s Disease (HD).
Marian DiFiglia leads a multidisciplinary research team investigating the role of the HD mutation in the molecular and cellular events leading to neurodegeneration.
Dr. Dunah's research involves exploring the mechanisms and signaling pathways by which dysregulation of NMDA receptor functions causes parkinsonism and dyskinesias using in vivo and in vitro models.
Dr. Frosch's laboratory studies the development and characterization of animal models of human neurodegenerative diseases, particularly Cerebral amyloid angiopathy (CAA), Alzheimer and Parkinson diseases.
Dr. Gomez-Isla’s research includes basic science using transgenic mouse models of Alzheimer’s disease and dementia, analyzing data on clinical, neuroimaging and genetic features of demented patients and healthy controls. She also manages multiple clinical trials.
Dr. Gomperts' basic science interests focus on understanding how dopamine cells and cells of the hippocampus communicate with one another and with their target regions to guide behaviors.
Dr. Guénette’s research focuses on the molecular pathways that impact amyloid precursor protein (APP) function, as well as the generation and degradation of b-amyloid, a peptide central to the etiology of Alzheimer’s disease.
Dr. Hersch's clinical and research interests are in neurodegenerative disorders and particularly Huntington's disease (HD).
Dr. Hyman’s research program studies the neural system failure that underlies cognitive loss in Alzheimer’s, and how genetics impacts pathophysiology.
Dr. Kazantsev's laboratory is focused on discovery therapeutic agents for Huntington's and Parkinson's diseases using methods of high throughput screening, rational drug design, and medicinal chemistry lead optimization.
Dr. Kegel studies the normal and altered function of huntingtin (htt), the protein mutated in Huntington Disease.
Dr. Doo Yeon Kim, of the Genetics and Aging Research Unit, is part of Dr. Dora Kovac's team, studying beta-secretase (BACE), an enzyme in the brain which can release small fragments of the amyloid precursor protein (APP), the main ingredient for Alzheimer’s plaques.
Dr. Kovac's research focuses on the molecular events underlying neurodegeneration in Alzheimer’s disease.
The primary focus of Dr. Li's research is applying the genetics of Drosophila to identify and characterize novel Alzheimer's disease genes.
Michele Maxwell is examining the possibilities of using a cutting edge technique called RNA interference as a way to understand ALS and mimic the effects of potential therapeutics.
Dr. McLean uses genetic and molecular approaches to understand the cellular and molecular mechanisms underlying neurodegeneration in Parkinson's disease, dementia with Lewy bodies and related disorders.
Dr. Moir's work focuses on the biochemical and cellular mechanisms involved in neurodegeneration in Alzheimer's disease and aging.
Dr. Rosas and her team investigate the regional and temporal progression of changes that occur in the normal aging process of the brain, and how those are distinct from Huntington’s and other neurodegenerative diseases.
Dr. Sadri-Vakili's research focuses on delineating the molecular mechanisms that underlie transcriptional dysregulation in Huntington's disease.
Dr. Schwarzschild's research largely focuses on the role of three purines--adenosine, caffeine and urate--in animal models of Parkinson's disease.
Dr. Tanzi's research is primarily aimed at identifying and characterizing Alzheimer’s disease-associated gene mutations/variants with the ultimate goal of defining the molecular, cellular, and biochemical events leading to neuronal cell death in the brains of AD patients.
Dr. Vanderburg's current research focus is on the microgenomic and microproteomic profiling of human neuropathological tissue specimens and their derivatives, including miRNAs and exosomes.
Dr. Antonio Valencia is currently investigating Huntington’s disease (HD), focusing on cell survival pathways, oxidative damage, altered membrane function and neurodegeneration.
The aim of the Wainger Laboratory is to ask clinically relevant research questions that could lead to rapid translation and innovation for treating diseases of the motor and sensory nervous systems.
Dr. Wasco studies the regulation and function of genes that have been associated with Alzheimer's disease.
Dr. Young directs a comprehensive drug discovery program at MIND, which has been successful in identifying drug targets for Parkinson’s, Huntington’s and other neurodegenerative diseases. Her laboratory also studies the role of the protein alpha-synuclein,