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Young Laboratory - Anne B. Young, MD - CLOSED

Dr. Young’s laboratory is examining the role of the protein alpha-synuclein, which plays a key role in the death of dopamine-producing brain cells in the Parkinson’s disease and other diseases with similar symptoms.
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Please note that this lab has been closed.Overview

Dr. Young’s laboratory is examining the role of the protein alpha-synuclein, which plays a key role in the death of dopamine-producing brain cells in the Parkinson’s disease and other diseases with similar symptoms.

Recently Dr. Young’s laboratory has examined the biology of synuclein in a group of Parkinson-like disorders, the Multiple Systems Atrophies. These studies suggest novel mechanisms in synuclein turnover, which may be relevant for treatments targeted at this protein.

Dr. Young is the Principal Investigator of the MGH Morris K. Udall Center of Excellence in Parkinson’s Disease Research, which brings together scientists in several laboratories at both institutions to try to understand the molecular mechanisms of Parkinson’s disease.

In addition to her work in Parkinson’s disease, Dr. Young’s laboratory is attempting to elucidate cellular and systems mechanisms underlying the pathophysiology of Huntington’s disease. In an effort to help develop therapeutic targets for human movement disorders, she is conducting studies on the vulnerability of neurons to excitotoxic injury and the selective expression of glutamate receptors in these neurons.

Her lab was also among the first to apply the new technology of large-scale DNA micro-array analysis to both Huntington’s and Parkinson’s disease, revealing the importance of gene dysregulation in these disorders. Her group is pursuing the role that specific genes may play in the progression of Parkinson’s disease.

Biography

Anne B. Young, MD, PhD

Principal Investigator

Anne B. Young, MD, PhD
Professor of Neurology, Harvard Medical School

Research Interests:  Huntington's disease, Parkinson’s disease

Diseases Studied: Huntington's disease, Alzheimer’s disease, ALS, neurodegenerative disease

Research Scientists

Hollingsworth, Zane - Instructor, Lab Operations Manager

Gender differences in Parkinson’s disease

Drs. Anne B. Young, Ippolita Cantuti-Castelvetri and Michael Schwarzschild study gender differences in Parkinson’s disease from three different investigative approaches.

MassGeneral Institute for Neurodegenerative Disease

Building 114, Charlestown Navy Yard
Mailcode: CNY B114-2-2003
114 16th Street, Room 2003
Charlestown, MA 02129

Phone: 617-726-2000
Fax: 617-724-1480

Public Transportation Access: yes
Disabled Access: yes

How to Apply for Positions

How to apply for jobs: Send an e-mail to mghneurologyjobs@partners.org to receive an automated e-mail with full instructions for all types of positions.

Fundraising Contact

Contact Shawn Fitzgibbons in the Mass General Development office at 617-643-0447 or sfitzgibbons@partners.org.

Administration

Anne B. Young, MD, PhD
Director, Massgeneral Institute for Neurodegenerative Disease 
Professor of Neurology, Harvard Medical School

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Clinical Appointments, Consultations & Clinical Trials

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