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Moir Lab

Dr. Robert Moir's research focuses on the biochemical and cellular mechanisms involved in neurodegeneration in Alzheimer's disease and aging.

The Moir Lab focuses on the biochemical and cellular mechanisms involved in neurodegeneration in Alzheimer's disease (AD) and aging. More specifically, receptor/ligand interactions and physiochemical properties that promote pathological protein behavior. Particular emphasis has been placed on the beta-amyloid peptide (A beta), amyloid precursor protein (APP), apolipoprotein E, low density lipoprotein receptor protein (LRP), alpha-2-macroblobulin and the presenilins (PS1 and PS2).

Research Investigator Profile

Robert D. Moir, PhD

Robert D. Moir, PhD

  • Assistant Professor in Neurology,
    Harvard Medical School
  • Assistant Professor in Neurology,
    MGH Neurology Research

  1. Kounnas MZ, Moir RD, Rebeck CW, Bush AI, Argraves WS, Tanzi RE, Hyman BT and Strickland DK. LDL receptor-related protein, a mulitfunctional apolipoprotein E receptor, binds secreted beta-amyloid precursor protein and mediates its degradation. Cell 1995; 82: 331 40.
  2. Moir RD, Lynch T, Bush AI, Multhaup G, Whyte S, Tanzi RE, Small DH, Beyreuther, K and Masters, CL. Relative increase in Alzheimer's disease of soluble forms of cerebral A beta amyloid protein precursor containing the Kunitz Protease Inhibitory domain. J. Biol. Chem. 1998; 273: 5013-5019.
  3. Moir RD, Bush AI, Romano DM, Atwood CS, Huang X., Smith J and Tanzi RE. Differential effects of apolipoprotein E isoforms on metal-induced aggregation of A beta under physiological conditions. Biochemistry 1999; 38: 4595-4603.
  4. Goldstein LE, Muffat JA, Cherny RA, Moir RD, Ericsson MH, Huang X, Mavros C, Coccia JA, Faget KY, Fitch KA, Masters CL, Tanzi RE, Chylack LT, Bush AI. Cytosolic beta-amyloid deposition and supranuclear cataracts in lenses from people with Alzheimer's disease. Lancet 2003; 361: 1258-1265.
  5. Soscia SJ, Kirby JE, Washicosky KJ, Tucker SM, Ingelsson M, Hyman B, Burton MA, Goldstein LE, Duong S, Tanzi RE, Moir RD. The Alzheimer’s Disease-Associated Amyloid-beta Protein Is an Antimicrobial Peptide. PLoS ONE 2010; 5 (3): 1-10.

NCBI PubMed Publications